Synergizing Artificial Intelligence and Probiotics: A Comprehensive Review of Emerging Applications in Health Promotion and Industrial Innovation

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104938 - 104938

Published: Feb. 1, 2025

Language: Английский

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Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

European Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 119, P. 13 - 30

Published: Oct. 4, 2023

Language: Английский

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Microbial Dysbiosis Linked to Metabolic Dysfunction-Associated Fatty Liver Disease in Asians: Prevotella copri Promotes Lipopolysaccharide Biosynthesis and Network Instability in the Prevotella Enterotype

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2183 - 2183

Published: Feb. 11, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly known as non-alcoholic (NAFLD), is characterized by hepatic fat accumulation metabolic dysfunction. The rising prevalence of MAFLD, especially among Asians, may be associated with changes in gut microbiota. We investigated microbiota characteristics and potential mechanisms leading to MAFLD development according enterotypes. Case-control studies examining the composition between non-MAFLD participants were searched public databases until July 2023. Gut was categorized into two enterotypes principal component analysis. According enterotypes, LEfSe, ALDEx2, XGBoost, DCiPatho utilized identify differential abundances pathogenic microbes groups. analyzed microbial community networks SprCC module predicted functions. In Prevotella enterotype (ET-P), 98.6% Asians 65.1% Caucasians (

Language: Английский

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Enterotype-stratified gut microbial signatures in MASLD and cirrhosis based on integrated microbiome data

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health challenge, characterized by significant variability in progression and clinical outcomes. While the gut microbiome increasingly recognized as key factor development, its role associated mechanisms remains unclear. This study systematically investigated microbiota’s MASLD cirrhosis progression, focusing on individual bacterial strains, microbial community dynamics, functional characteristics across different enterotypes. Methods Publicly available next-generation sequencing(NGS) datasets from healthy individuals patients with were analyzed. Enterotype classification was performed using principal component analysis, advanced bioinformatics tools, including Linear Discriminant Analysis Effect Size (LEfSe), eXtreme Gradient Boosting (XGBoost), Deep Cross-Fusion Networks for Genome-Scale Identification of Pathogens (DCiPatho), to identify differentially abundant microbes potential pathogens. Microbial co-occurrence networks predictions via PICRUSt2 revealed distinct patterns Results discussion The Prevotella-dominated(ET-P) group exhibited 33% higher rate than Bacteroides-dominated(ET-B) group. Unique signatures identified: Escherichia albertii Veillonella nakazawae ET-B, while Prevotella copri linked MASLD. In ET-P, hominis Clostridium saudiense significantly cirrhosis. Functional analysis reduced biosynthesis fatty acids, proteins, short-chain acids (SCFAs), coupled increased lipopolysaccharide(LPS) production altered secondary bile acid metabolism patients. There differences enterotypes providing critical insights developing personalized microbiome-targeted interventions mitigate progression.

Language: Английский

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Inhibition of intestinal FXR activity as a possible mechanism for the beneficial effects of a probiotic mix supplementation on lipid metabolism alterations and weight gain in mice fed a high fat diet

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Nov. 20, 2023

Supplementation with probiotics has emerged as a promising therapeutic tool to manage metabolic diseases. We investigated the effects of mix Bifidobacterium animalis subsp. lactis LA804 and Lactobacillus gasseri LA806 on high-fat (HF) diet -induced disease in mice. probiotic HF diet-fed mice (HF-Pr2) reduced weight fat mass gains, decreased hepatic lipid accumulation, lowered plasma triglyceride peak during an oral tolerance test. At molecular level, protected against HF-induced rise mRNA levels genes related uptake, metabolism, storage liver white adipose tissues, strongly inflammation tissue oxidative stress liver. Regarding intestinal homeostasis, did not prevent gut permeability but slightly modified microbiota composition without correcting dysbiosis induced by diet. Probiotic supplementation also cecal bile acid (BA) profile, leading increase Farnesoid-X-Receptor (FXR) antagonist/agonist ratio between BA species. In agreement, HF-Pr2 exhibited strong inhibition FXR signaling pathway ileum, which was associated metabolism protection. This is consistent recent reports proposing that activity could be potent mechanism overcome disorders. Altogether, our results demonstrate evaluated, when administered preventively limit obesity disorders, likely through tract.

Language: Английский

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The food additive xylitol enhances the butyrate formation by the child gut microbiota developed in a dynamic colonic simulator

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 187, P. 114605 - 114605

Published: March 25, 2024

The gut microbiota should be included in the scientific processes of risk assessment food additives. Xylitol is a sweetener that shows low digestibility and intestinal absorption, implying high proportion consumed xylitol could reach colonic microbiota. present study has evaluated dose-dependent effects intake on composition metabolic activity child gut-microbiota. was conducted dynamic simulator (BFBL Gut Simulator) inoculated with pooled faecal sample supplemented three times per day, for 7 days, increasing concentrations (1 g/L, 3 g/L 5 g/L). Sequencing 16S rRNA gene amplicons group-specific quantitative PCR indicated dose-response effect abundance Lachnospiraceae, particularly genera Blautia, Anaerostipes Roseburia. microbial changes observed corresponded dose-dependant butyrate concentration that, parallel, favoured an increase epithelial integrity Caco-2 cells. represents detailed observation bacterial taxa are main contributors to metabolism by results relevant re-evaluation as sweetener.

Language: Английский

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Bacteroides uniformis Ameliorates Carbohydrate and Lipid Metabolism Disorders in Diabetic Mice by Regulating Bile Acid Metabolism via the Gut–Liver Axis

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1015 - 1015

Published: Aug. 1, 2024

Background: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterized by chronic inflammation, insulin resistance, and islet cell damage. The prevention of T2DM its associated complications an urgent public health issue that affects hundreds millions people globally. Numerous studies suggest disturbances in gut metabolites are important driving forces for the pathogenesis diabetes. However, functions mechanisms action most commensal bacteria remain largely unknown. Methods: quantification bile acids (BAs) fecal samples was performed using ultra-performance liquid chromatography–tandem mass spectrometer (UPLC-MS/MS). anti-diabetic effects Bacteroides uniformis (B. uniformis) cholic acid (CA) chenodeoxycholic (CDCA) were assessed mice induced streptozocin (STZ) plus high-fat diet (HFD). Results: We found abundance B. feces contents CA CDCA significantly downregulated mice. diminished diabetic individuals this bacterium sufficient to promote production BAs. Colonization intragastric gavage effectively improved disorder glucose lipid metabolism inhibiting gluconeogenesis lipolysis liver. hepatic acting on Takeda G protein-coupled receptor 5 (TGR5)/adenosine monophosphate-activated protein kinase (AMPK) signaling pathway since knockdown TGR5 minimized benefit CDCA. Furthermore, we screened natural product—vaccarin (VAC)—that exhibited promoting growth vitro vivo. Gut microbiota pre-depletion abolished favorable VAC Conclusions: These data supplementation may be promising avenue ameliorate linking

Language: Английский

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Metabolic and lifestyle factors accelerate disease onset and alter gut microbiome in inflammatory non-communicable diseases

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 24, 2024

Abstract Background Biomedical and lifestyle factors in Western populations have significantly shifted recent decades, influencing public health contributing to the increasing prevalence of non-communicable diseases (NCDs) that share inflammation as common pathology. Methods We investigated relationship between these 11 NCDs cross-sectional FoCus cohort ( n = 1220), using logistic regression models. Associations with age-at-disease-onset were specifically analyzed for type 2 diabetes (T2D, low-grade chronic inflammation) inflammatory bowel disease (IBD, high-grade disease-specific cohorts (FoCus-T2D, 514; IBD-KC, 1110). Important risk identified Cox-PH-regression models time-to-event analysis. further explored interaction gut microbiome composition linear Results Lifestyle clearly linked phenotypes, particularly T2D IBD. Still, some affected only age-at-onset, but not prevalence. High-quality nutrition delayed onset both IBD (IBD: HR 0.81 [0.66; 0.98]; T2D: 0.45 [0.28; 0.72]). Smoking accelerated (HR 1.82 [1.25; 2.65]) ulcerative colitis (UC: 0.47 0.79]). Higher microbiota diversity (Shannon: 0.58 [0.49; 0.71]) had no effect on T2D. The abundance specific microbial genera was strongly associated various biomedical In unaffected controls, effects smaller or reversed, potentially indicating a greater susceptibility negative influences Conclusions dual insights into emphasize role certain factors, e.g., quality, prevention management. Understanding relationships provides foundation developing targeted strategies mitigate impact metabolic through modifications

Language: Английский

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Moderate-intensity continuous training and high-intensity interval training alleviate glycolipid metabolism through modulation of gut microbiota and their metabolites SCFAs in diabetic rats

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 735, P. 150831 - 150831

Published: Oct. 13, 2024

Language: Английский

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Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility

Medical Microbiology and Immunology, Journal Year: 2024, Volume and Issue: 213(1)

Published: June 28, 2024

Language: Английский

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