Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

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Role of MARK2 in the nervous system and cancer

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(4), P. 497 - 506

Published: Feb. 2, 2024

Language: Английский

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CD2AP promotes the progression of glioblastoma multiforme via TRIM5-mediated NF-kB signaling

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(10)

Published: Oct. 1, 2024

Language: Английский

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An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB regulates a wide range physiological processes, such as survival, growth, migration. Deregulated NF-kB resulted in unregulated proliferation, viability, movement, invasion, thus promoting tumor development. Recent findings have increasingly shown that plant derived phytochemicals inhibit potential to be employed cancer therapeutics. Flavonoids are group polyphenolic natural compounds present various plants their fruits, vegetables, leaves. These medicinal properties owing antioxidant, anti-inflammatory, antiviral, antitumor characteristics. The main mechanism by which these flavonoids exhibit anticancer via potent antioxidative immunomodulatory actions. Current research reports demonstrated exhibited effects suppressing signaling. Based on facts, we comprehensively outlined role processes progression, drug resistance, angiogenesis metastasis. In addition these, also summarize specifically targeting types cancers.

Language: Английский

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The Role of Osteoprotegerin in Breast Cancer: Genetic Variations, Tumorigenic Pathways, and Therapeutic Potential

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 337 - 337

Published: Jan. 21, 2025

Introduction: Osteoprotegerin (OPG), encoded by the TNFRSF11B gene, is linked to development of breast cancer via several pathways, including interactions with receptor activator nuclear factor-κB (RANK) ligands, apoptosis-inducing proteins like TRAIL, and genetic variations such as single nucleotide polymorphisms (SNPs), directly altering gene expression. This review aims investigate role OPG expression in cancer. Methods: A comprehensive literature search was conducted using PubMed Medline, Google Scholar, ScienceDirect. Only full-text English publications from inception September 2024 were included. Results: Studies have demonstrated that certain SNPs specifically rs3102735 rs2073618, are a higher risk development. Additionally, OPG’s function TRAIL decoy may inhibit death cells. Furthermore, serum its BRCA mutations being investigated for their potential influence on progression. found promotes tumorigenesis enhancing cell proliferation, angiogenesis, aneuploidy normal mammary epithelial Moreover, mediates tumor-promoting effects interleukin-1 beta serve biomarker risk, particularly BRCA1 mutation carriers, through dysregulated RANK signaling. Lastly, use recombinant mouse models has been exert anti-tumor effects. Conclusions: In this review, examined. multifaceted exerts TNF-related ligand (TRAIL), modulation pro-tumorigenic microenvironment survival, metastasis. dual tumor suppressor promoter serves possible therapeutic target enhance apoptosis, limit bone metastasis, modulate microenvironment. Whilst much now known, further studies necessary fully delineate OPG.

Language: Английский

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Angiogenin: biological role, mechanisms of action, and participation in oncogenesis

Bulletin of Siberian Medicine, Journal Year: 2025, Volume and Issue: 23(4), P. 169 - 176

Published: Jan. 27, 2025

Angiogenin is a small polypeptide consisting of 123 amino acids involved in the processes angiogenesis and tumorigenesis. This protein plays an important role various physiological pathological through regulation cell proliferation, survival, migration, invasion, differentiation. The lecture presents data on angiogenin production interaction with proteins, describes mechanisms its action, shows biological oncogenesis. literature search was carried out PubMed, Medline, Elibrary, Scopus, Cochrane Library, RSCI engines.

Language: Английский

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Advances on the therapeutic potential of cell receptor activation in glioblastoma

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 5, 2025

Language: Английский

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Chromobox protein homolog 7 suppresses the stem-like phenotype of glioblastoma cells by regulating the myosin heavy chain 9-NF-κB signaling pathway

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 23, 2025

Language: Английский

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TAB2 Promotes Immune Escape and Chemoresistance Through NF‐κB Pathway Activation in Cervical Cancer

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(6)

Published: March 1, 2025

ABSTRACT Cervical cancer (CC) remains a major health challenge with high mortality rates due to chemoresistance and immune escape. However, the underlying mechanisms remain unclear. We investigated role of TAB2 in CC using cisplatin‐resistant parental cell lines. Cell proliferation, migration, sphere formation T cell‐mediated killing assays were performed. Western blot qRT‐PCR analysed protein mRNA expression. NF‐κB pathway involvement was examined BAY 11–7082 inhibitor. expression significantly elevated cells. overexpression promoted escape through activation. Conversely, knockdown or inhibition sensitised resistant cells cisplatin enhanced killing. The phenotype could be rescued by restoring PD‐L1 Our findings reveal as critical regulator both This suggests potential therapeutic target for overcoming treatment resistance CC.

Language: Английский

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Therapeutic Potential of NF-κB Inhibition in Glioblastoma: Gene Therapy Approach with rAAV-5 Mediated IκBαM Overexpression

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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