Beveled microneedles with channel for transdermal injection and sampling, fabricated with minimal steps and standard MEMS technology DOI
Alvise Bagolini, Nicolò G. Di Novo,

Severino Pedrotti

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Microneedles hold the potential for enabling shallow skin penetration applications where biomarkers are extracted from interstitial fluid (ISF) and drugs injected in a painless effective manner.

Language: Английский

Review—Smart Wearable Sensors for Health and Lifestyle Monitoring: Commercial and Emerging Solutions DOI Creative Commons
N. M. Cusack, Prabhuraj D. Venkatraman, Umar Raza

et al.

ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(1), P. 017001 - 017001

Published: March 1, 2024

The rapid growth of urbanisation has brought about various health concerns for citizens living in urban environments. Sedentary lifestyles, increased pollution levels, and high levels stress have become prevalent issues affecting the overall well-being populations. In recent years, emergence smart wearable devices offered a promising avenue to address these promote healthier lifestyles. This review evaluatse effectiveness wearables mitigating improving lifestyles citizens. involves 50 relevant peer-reviewed studies supporting literature from electronic databases PubMed, Ovid, Web Science, Scopus. Results indicate that potential positively impact by promoting physical activity, tracking vital signs, monitoring sleep patterns, providing personalised feedback recommendations activity levels. Furthermore, can help individuals manage enhance self-awareness, foster behaviours. However, also identifies several challenges, including accuracy reliability data, user engagement adherence, ethical considerations regarding data privacy security.

Language: Английский

Citations

30
Harvesting and manipulating sweat and interstitial fluid in microfluidic devices DOI Creative Commons
Tamoghna Saha, Sneha Mukherjee, Michael D. Dickey

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1244 - 1265

Published: Jan. 1, 2024

This review focuses on microfluidic techniques for sampling, sensing, and managing of sweat interstitial fluid (ISF).

Language: Английский

Citations

17
Recent advances in microneedles for drug delivery and theranostic application DOI
Mayuri Gupta,

Nimisha Srivastava,

Anil Rai

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: 228, P. 113773 - 113773

Published: Jan. 31, 2025

Language: Английский

Citations

4
Stimuli-responsive hydrogel dressing for wound healing DOI Creative Commons
Wei Zhang, Jun Hu, Hao Wu

et al.

APL Materials, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, effective wound management still major challenge in clinical nursing settings. The microenvironment collectively regulated by internal biomolecules, external drugs, sanitation. Traditional dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during processes because they cannot respond to the dynamic changes over long-term. Stimulus-responsive biomaterials, which are activated various factors intrinsic influences, hold great promise for precise drug delivery controlled release. Various stimulus-responsive hydrogels been developed recent years, exhibiting range of “smart” properties, such interacting with wound, sensing conditions environmental changes, responding accordingly, thereby effectively promoting healing. This review discusses latest advancements used We introduce design scheme stimulus-response detail based on local biological/biochemical peculiarities (pH, reactive oxygen species glucose, enzymes, physical microenvironments (temperature, light, ultrasound, electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, microspheres). Finally, summarize basis active research challenges, current progress, development trends field.

Language: Английский

Citations

3
Opportunities and Challenges of Microneedle Electrochemical Sensors for Interstitial Fluid Detection DOI
Yanming Dong,

Siying Mao,

Shiwei Chen

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117891 - 117891

Published: July 31, 2024

Language: Английский

Citations

14
Polysaccharide hydrogels for skin wound healing DOI Creative Commons

Meifen Liu,

Jiman Jin,

Xiqiang Zhong

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35014 - e35014

Published: July 22, 2024

Language: Английский

Citations

11
A swellable hydrogel microneedle based on cerium-metal organic frame composite nanozyme for detection of biomarkers DOI

Jiuhong Zhao,

Jiatong Lv,

Guixia Ling

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127745 - 127745

Published: Oct. 29, 2023

Language: Английский

Citations

22
Hydrogel‐Forming Microneedles and Applications in Interstitial Fluid Diagnostic Devices DOI Creative Commons
Angélica F. Aroche,

Hannah E. Nissan,

Michael A. Daniele

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Hydrogel‐forming microneedles are constructed from or coated with polymeric, hydrophilic materials that swell upon insertion into the skin. Designed to dissolve disintegrate postinsertion, these can deliver drugs, vaccines, other therapeutics. Recent advancements have broadened their application scope include collection, transport, and extraction of dermal interstitial fluid (ISF) for medical diagnostics. This review presents a brief introduction characteristics ISF, methods sampling, critical assessment state‐of‐the‐art in hydrogel‐forming ISF Key factors evaluated including material composition, swelling behavior, biocompatibility, mechanical strength necessary effective microneedle performance collection. The also discusses successful examples assays sensor integrations, highlighting notable achievements, identifying research opportunities, addressing challenges potential solutions. Despite predominance synthetic hydrogels reported technologies due favorable gelation properties, there is significant variety biopolymers composites literature. field lacks consensus on optimal material, fabrication methods, though emerging evidence suggests processing techniques utility

Language: Английский

Citations

6
Rapid detection of antibodies in skin interstitial fluid via fluorescent testing using antigen-modified porous microneedles DOI
Mengxin Xu,

Ying Liu,

Huimin Chen

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 693, P. 133987 - 133987

Published: April 16, 2024

Language: Английский

Citations

5
Microneedle Array‐Based Dermal Interstitial Fluid Biopsy for Cancer Diagnosis: Advances and Challenges DOI Open Access

Chaima Merzougui,

Xi Yang, Dianhuai Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Current early cancer diagnostic technologies, such as imaging, molecular tests, endoscopic techniques, and biopsies, face considerable challenges in low‐and middle‐income countries (LMICs) due to high costs, procedural complexity, limited resource access. Microneedle‐based liquid biopsy for skin interstitial fluid (ISF) offers a practical minimally invasive alternative diagnosis these settings. This review systematically examines ISF methods their effectiveness capturing biomarkers directly from the assesses potential address needs low‐resource environments. Recent innovations microneedle design underscore enabling early, accessible detection tailored LMICs' needs. Additionally, integrating artificial intelligence (AI) data interpretation is proposed way enhance accuracy enable real‐time point‐of‐care (POC) applications. Collectively, advances illustrate flexible, scalable model diagnostics, with significant implications improving healthcare quality resource‐limited

Language: Английский

Citations

0