Lab on a Chip,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Microneedles
hold
the
potential
for
enabling
shallow
skin
penetration
applications
where
biomarkers
are
extracted
from
interstitial
fluid
(ISF)
and
drugs
injected
in
a
painless
effective
manner.
Advanced Materials Technologies,
Journal Year:
2023,
Volume and Issue:
9(4)
Published: Dec. 27, 2023
Abstract
Wound
infections
caused
by
invasive
pathogens
become
an
increasing
global
challenge
health.
Porous
microneedles
(MNs)
present
distinctive
advantages
for
non‐invasive
and
in
situ
detection
of
wound
infections,
enabling
the
extraction
interstitial
fluid,
skin
sweat,
saliva
other
biological
samples.
Consequently,
porous
MNs
find
widespread
acceptance
medical
detection,
drug
delivery,
monitoring
physiological
indicators.
Based
on
these
advantages,
emerging
clinical
applications
classifications
is
first
introduced,
covering
mechanical
strength,
methods
antibody
probe
modification
onto
MNs,
signal
amplification
techniques
biomarkers
analysis.
At
same
time,
specific
immunology
electrochemistry
introducing
to
enhance
target
molecules,
such
as
rolling
circle
amplification,
gold/silver
nanoparticles,
fluorescence
origami
microneedle
so
try
summarized.
The
improvement
sensitivity
realized
integrating
various
strategies
diverse
methods.
Meanwhile,
it
briefly
illustrated
detections.
Finally,
challenges
future
prospects
using
practical
discussed.
Lab on a Chip,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Microneedles
hold
the
potential
for
enabling
shallow
skin
penetration
applications
where
biomarkers
are
extracted
from
interstitial
fluid
(ISF)
and
drugs
injected
in
a
painless
effective
manner.