A Feasibility Study on the Use of UV‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates DOI
Baoling Jia,

Tiandong Xia,

Xiaohui Wang

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT Microneedle (MN) has significant potential for transdermal glucose monitoring. However, challenges remain in selecting suitable materials long‐acting monitoring MN. In this study, precise solid UV‐curable resin MN patches were fabricated using a synergistic combination of the micromolding method and UV‐curing procedure, as an alternative to previous 3D printing. The properties UV‐cured prepared evaluated characterized, focusing on their results demonstrated that exhibited superior shape stability, very low cytotoxicity, minimal skin irritation, fracture force approximately 2.289 N/needle. Following immersion 37°C PBS different days, mass changed negligibly, still reached half original values after 21 days. is highly promising substrate MN, study provides new material selection strategy development.

Language: Английский

Microneedle Optimization: Toward Enhancing Microneedle's Functionality and Breaking the Traditions DOI Creative Commons

Elham Lori Zoudani,

Nam‐Trung Nguyen, Navid Kashaninejad

et al.

Small Structures, Journal Year: 2024, Volume and Issue: 5(12)

Published: Aug. 14, 2024

Microneedles hold remarkable potential for providing convenient and unique solutions disease diagnosis therapy. However, their integration into clinical practices has been slow, primarily due to the challenge of developing models that meet criteria a particular application. A comprehensive systematic analysis all aspects microneedle platforms is imperative overcome this bottleneck. The involves gathering performance‐related information understanding factors affecting functionality microneedles. performance microneedles heavily influenced by parameters such as dimensions, needle shape, array arrangement, materials (flexible, stretchable, stimuli‐responsive, biodegradable). This article presents fresh perspective on microneedles, introducing concepts toward optimal designs across various platforms. includes application, design, fabrication techniques, how specific design can effectively requirements By addressing these crucial issues, further advancement technology occurs.

Language: Английский

Citations

5
Staggered Design of UV–Curable Polymer Microneedle Arrays with Increased Vertical Action Space DOI Open Access
Baoling Jia,

Tiandong Xia,

Yangtao Xu

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(1), P. 104 - 104

Published: Jan. 2, 2025

Recent studies have identified microneedle (MN) arrays as promising alternatives for transdermal drug delivery. This study investigated the properties of novel staggered MN design featuring two distinct heights MNs. The were precisely fabricated via PμSL light-cured 3D printing technology. systematically evaluated their morphology, fracture force, skin penetration ability, mechanism, and delivery capability. results demonstrated that punctured incrementally, leveraging benefits deformation during puncture process. approach effectively reduced force needed, achieving a maximum reduction approximately 80.27% due to variations in height. Additionally, facilitated penetration, confirmed by rat hematoxylin-eosin (H&E) staining experiments. Compared with 3D-printed planar structures highly uniform arrays, exhibited enhanced hydrophilicity, evidenced contact angle from 93° 70°. Simulated release images both coated hollow MNs illustrated capabilities these across various layers, expanded effective area within vertical dimension layers. offers experimental theoretical foundations developing three–dimensional structural distributions, thereby facilitating advancements array

Language: Английский

Citations

0
Morphology Design and Precision Control of Microneedles by PμSL 3D Printing DOI Open Access
Baoling Jia,

Tiandong Xia,

Yangtao Xu

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(10), P. 1351 - 1351

Published: May 15, 2025

Microneedles (MNs) hold significant potential for applications in transdermal drug delivery and biosensing. However, when traditional 3D printing technology is used their manufacture, a substantial deviation output size occurs. The effects of various parameters on the morphology MNs produced through microscale remain unclear. This study investigated relationship between design fabrication acrylic resin forms via projection microstereolithography (PµSL) system. Modifying shape array configurations elucidates causes proposes control strategy. particularly prototyping mold manufacturing relevant fields. indicates that layer thickness 10 µm optimally balances efficiency clinical conversion requirements. Additionally, an exposure intensity 65 mW/cm2 achieves both high fidelity appropriate base size. angle significantly influences mechanical properties MNs. diameter aspect ratio solid correlate with dimensional stability. Clinically, conical or quadrilateral defined are recommended. A critical spacing (≥40 µm) optimal arrangement MN arrays were established. specific vertical hollow ensure precision micropore wall thickness. approach offers theoretical insights process essential high-precision, customizable engineering design.

Language: Английский

Citations

0
Investigation of biosensing properties in magnetron sputtered metallized UV-curable polymer microneedle electrodes DOI
Baoling Jia,

Tiandong Xia,

Xiaohui Wang

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(7), P. 1008 - 1030

Published: Feb. 22, 2024

Direct management and assessment of metal film properties applied to polymer microneedle (MN) biosensors remains difficult due constraints inherent their morphology. By simplifying the three-dimensional structure MNs adjusting deposition time, different thicknesses Au films were deposited on UV-cured planar MN substrates. Several relevant biosensing grown surfaces investigated. The results demonstrate successful pure stable nanoparticles onto surface UV-curable materials. Initially, islands formed within first minute deposition; however, as sputtering time extended, these transformed into nanoparticle disappeared. hydrophilicity unchanged, while resistance thin decreases with increasing thickness, adhesion substrate thickness increases. In short, a 5-6 min in 100-200 nm, which exhibit exceptional comprehensive performance. Additionally, made Au/UV-curable polymers produced using magnetron maintain original shape, enhance mechanical characteristics, gain new functionalities. exhibited remarkable electrode performance despite being soaked 37 °C PBS solution for 14 days. These discoveries have important implications terms decreasing dependence valuable metals biosensors, lowering production expenses, providing guidance choice design materials metallization films.

Language: Английский

Citations

2
A Feasibility Study on the Use of UV‐Curable Resins for Long‐Acting Monitoring Microneedle Substrates DOI
Baoling Jia,

Tiandong Xia,

Xiaohui Wang

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT Microneedle (MN) has significant potential for transdermal glucose monitoring. However, challenges remain in selecting suitable materials long‐acting monitoring MN. In this study, precise solid UV‐curable resin MN patches were fabricated using a synergistic combination of the micromolding method and UV‐curing procedure, as an alternative to previous 3D printing. The properties UV‐cured prepared evaluated characterized, focusing on their results demonstrated that exhibited superior shape stability, very low cytotoxicity, minimal skin irritation, fracture force approximately 2.289 N/needle. Following immersion 37°C PBS different days, mass changed negligibly, still reached half original values after 21 days. is highly promising substrate MN, study provides new material selection strategy development.

Language: Английский

Citations

0