Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108066 - 108066
Published: Dec. 17, 2024
Language: Английский
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)
Published: April 29, 2024
Abstract The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy immunotherapy. Arsenic trioxide (ATO) has emerged as a cytotoxic agent effective for treating solid tumors, including advanced HCC. However, its effectiveness in HCC remains limited, underlying mechanisms are still uncertain. Therefore, this study aimed characterize effects ATO By evaluating susceptibilities human murine cell lines treatment, we discovered that cells exhibited range sensitivity highlighting their heterogeneity. A gene signature comprising 265 genes was identified distinguish ATO-sensitive from ATO-insensitive cells. According signature, patients have also been classified differential features response. Our results showed induced reactive oxygen species (ROS) accumulation activation multiple death modalities, necroptosis ferroptosis, Meanwhile, elevated immunogenicity observed Similar were not We reported mitochondrial injury mtDNA release into cytoplasm tumors. This subsequently activated cGAS-STING-IFN axis, facilitating CD8 + T infiltration activation. found IFN pathway PD-L1 expression, potentially antagonizing ATO-mediated immune attack. Additional anti-PD1 therapy promoted anti-tumor response In summary, our data indicate heterogeneous responses exist significantly induces immunogenic (ICD) activates tumor-derived mtDNA-STING-IFN axis. These findings may offer new perspective on clinical warrant further study.
Language: Английский
Citations
13
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7264 - 7264
Published: July 1, 2024
Cancer is one of the leading causes morbidity and death worldwide, making it a serious global health concern. Chemotherapy, radiotherapy, surgical treatment are most used conventional therapeutic approaches, although they show several side effects that limit their effectiveness. For these reasons, discovery new effective alternative therapies still represents an enormous challenge for tumour diseases. Recently, anticancer peptides (ACPs) have gained attention cancer diagnosis treatment. ACPs small bioactive molecules which selectively induce cell through variety mechanisms such as apoptosis, membrane disruption, DNA damage, immunomodulation, well inhibition angiogenesis, survival, proliferation pathways. can also be employed targeted delivery drugs into cells. With over 1000 clinical trials using ACPs, potential application in therapy seems promising. Peptides utilized conjunction with imaging agents molecular methods, MRI, PET, CT, NIR, improving detection classification cancer, monitoring response. In this review we will provide overview biological activity some natural synthetic common malignant tumours affecting people around world.
Language: Английский
Citations
10
Jurnal Online Informatika, Journal Year: 2024, Volume and Issue: 9(1), P. 70 - 79
Published: April 26, 2024
This study aims to provide an overview of the current state-of-the-art applications artificial intelligence (AI) and machine learning in management hepatocellular carcinoma (HCC), explore future directions for continued progress this emerging field. is a comprehensive literature review that synthesizes recent findings advancements application AI techniques across various aspects HCC care, including screening early detection, diagnosis staging, prognostic modeling, treatment planning, interventional guidance, monitoring response. The draws upon wide range published research studies, focusing on integration with diverse data sources, such as medical imaging, clinical data, genomics, other multimodal information. results demonstrate AI-based systems have shown promise improving accuracy efficiency screening, diagnosis, tumor characterization compared traditional methods. Machine models integrating clinical, genomic outperformed conventional staging predicting survival recurrence risk. recommendation potential optimize personalized therapy selection, while augmented reality can guide procedures real-time. Moreover, longitudinal may enhance assessment response monitoring. Despite these promising findings, highlights need rigorous multicenter prospective validation standardized datasets, thoughtful consideration ethical implications before widespread implementation technologies management.
Language: Английский
Citations
6
Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 66 - 66
Published: Dec. 29, 2024
Hepatocellular carcinoma (HCC) is a major global health issue characterized by poor prognosis and complex tumor biology. One of the critical components HCC microenvironment (TME) tumor-associated macrophages (TAMs), which play pivotal role in modulating growth, immune evasion, metastasis. Macrophages are divided into two subtypes: pro-inflammatory M1 anti-inflammatory M2, both may exist TME with altered function proportion. The M2 further subdivided four distinct suppressive subsets. TAMs generally counted as M2-like functions that exert significant influence on cancer progression ability tumors to escape surveillance. Their involvement responses via different mechanisms at local systemic levels has made them key target for therapeutic interventions seeking enhance treatment outcomes. How TAMs’ depletion influences primary interest immunotherapies. purpose this review delve recent progress TAM-targeting therapies. We will explore current theories, benefits, challenges associated or inhibition. manuscript concludes future directions potential implications clinical practice.
Language: Английский
Citations
6
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 402, P. 111218 - 111218
Published: Aug. 28, 2024
Language: Английский
Citations
5
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 31, 2024
Abstract Background LncRNA colorectal neoplasia differentially expressed (CRNDE) was found to be an important regulator in many cancers. This project focuses on the function of CRNDE macrophage metabolic reprogramming and Hepatocellular carcinoma (HCC). Method qRT-PCR Immunofluorescence were used analyze Arg-1, IL-10, CD163, CCL-18, CD206, expression HCC tissues macrophages. Western Blotting ERK p-ERK expression. Edu assay, transwell assay xenograft experiments carried out study cell viability, migrated invasive capability. Immunohistochemical staining evaluate Ki67 A liquid chromatography-tandem mass spectrometry (LC-MS/MS) performed for macrophages metabolites analysis. Results significantly up-regulated tissues, M2 M0 with overexpressed (OV-CRNDE-M0), which downregulated knockdown (sh-CRNDE-M0). The conditioned medium (CM) cells OV-CRNDE-M0 promoted invasion, migration cells, effect reversed by sh-CRNDE-M0 CM. tumor growth, CD206 model. 61 detected, 18 changed group compared group, 9 upregulated downregulated. KEGG analysis showed enrichment pathways biosynthesis, glyoxylate dicarboxylate metabolism. SMPDB hypoacetylaspartia, canavan disease, aspartate Conclusion regulated via pathway, thereby contributed proliferation, migration, invasion.
Language: Английский
Citations
4
Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1961 - 1961
Published: Aug. 29, 2024
Circadian rhythms are endogenous behavioral or physiological cycles that driven by a daily biological clock persists in the absence of geophysical environmental temporal cues. rhythm-related genes code for proteins rise and fall rhythmic patterns driving biochemical signals processes from metabolism to physiology behavior. Clock have pivotal role liver homeostasis, their disturbances implicated various disease processes. Encoded play critical roles initiation progression metabolic dysfunction-associated steatohepatitis (MASH) hepatocellular carcinoma (HCC) may become diagnostic markers as well therapeutic targets. Understanding molecular mechanisms underlying circadian will aid interventions broader clinical applications. The present review provides an overview liver’s rhythm health disease, emphasizing MASH oncogenic associations lead HCC.
Language: Английский
Citations
3
Parasites & Vectors, Journal Year: 2025, Volume and Issue: 18(1)
Published: Feb. 21, 2025
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 9, 2025
Hepatocellular carcinoma (HCC) is an aggressive primary liver malignancy with a high potential for metastasis, commonly involving the lungs, bones, and lymph nodes. However, orbital metastasis exceptionally rare presentation. This case describes 73-year-old man history of HCC, hypertension, type 2 diabetes neuropathy, chronic obstructive pulmonary disease (COPD), hepatitis C, cirrhosis, portal hypertension who presented two-week blurry vision in left eye, numbness on forehead, sensation fullness. He also reported episode unintentional bilateral upper extremity jerking followed by nausea vomiting. Examination revealed left-sided proptosis, imaging identified retrobulbar mass muscle involvement. Biopsy confirmed metastatic HCC. Despite initial referral Y-90 radiotherapy, patient was unable to undergo treatment due multiple hospitalizations unrelated conditions. Following diagnosis he experienced rapid functional decline, including falls, cognitive deterioration, loss independence activities daily living, ultimately requiring hospice care. underscores importance recognizing patterns especially patients presenting ocular symptoms. It highlights severe consequences delayed cancer critical role coordinated care managing complex patients. Clinicians must remain vigilant identifying unusual symptoms HCC facilitate early timely intervention advanced disease.
Language: Английский
Citations
0
Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 14, 2025
Hepatocellular carcinoma (HCC) is a major global health concern, being the sixth most common cancer and third leading cause of deaths worldwide. Less than 30% HCC patients are eligible for curative treatment, primarily due to diagnosis at advanced stages. This emphasizes importance early detection in improving survival outcomes. In this study, we investigated methylation levels certain genes miRNAs liquid biopsy developed methyl predictive model (MPM-8G). The AUC MPM-8G was found be significantly higher that AFP (alpha-fetoprotein) alone. When were combined, increased notably, indicating combined use offers superior diagnostic performance enhances accuracy detection. Furthermore, combination proved powerful tool HCC. study successfully identified differences from patients, construction diagnosis. impressive these markers underscores their potential further clinical application management
Language: Английский
Citations
0