Epigenetic reprogramming as a key to reverse ageing and increase longevity

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102204 - 102204

Published: Jan. 23, 2024

The pursuit for the fountain of youth has long been a fascination amongst scientists and humanity. Ageing is broadly characterized by cellular decline with increased susceptibility to age-related diseases, being intimately associated epigenetic modifications. Recently, reprogramming-induced rejuvenation strategies have begun greatly alter longevity research not only tackle defects but also possibly reverse ageing process. Hence, in this review, we highlight major changes during state-of-art current emerging reprogramming leveraging on transcription factors. Notably, partial enables resetting clock without erasing identity. Promising chemical-based harnessing small molecules, including DNA methyltransferase histone deacetylase inhibitors are discussed. Moreover, parallel interventions, foundations clocks accurate assessment evaluation approaches briefly presented. Going further, such scientific breakthroughs, witnessing rise biotech industry aiming extend health span ideally achieve human one day. In context, overview main scenarios proposed future socio-economic ethical challenges an field. Ultimately, review aims inspire interventions that promote healthy all.

Language: Английский

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Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 390 - 390

Published: Feb. 24, 2024

Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.

Language: Английский

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Can Vaccines Stop Cancer Before It Starts? Assessing the Promise of Prophylactic Immunization Against High-Risk Preneoplastic Lesions

Journal of Cellular Immunology, Journal Year: 2023, Volume and Issue: 5(4), P. 127 - 140

Published: Nov. 29, 2023

Background: Cancer remains a leading cause of mortality with modest declines, highlighting the need for more efficacious prevention strategies like early immunological intervention against premalignant disease. Main body abstract: Oncogenic viruses demonstrate prophylactic vaccines can successfully reduce malignancy by blocking precipitating infections. However, most cancers lack viral etiology, requiring novel approaches targeting sporadic precancerous states to enable immunoprevention. Preneoplastic tissues exhibit biological changes making them appealing targets stimulating immune surveillance before additional mutations unconstrained proliferation. High-risk precancers also provide sources dysregulated self-antigens. Yet challenges exist in lesion identification, overcoming tolerance, and avoiding inflammation potentially worsening progression. Multidisciplinary insights into precancer immunology, predictive biomarkers, antigen discovery, combinatorial vaccination are illuminating rational vaccine design. Despite obstacles, immunization dysplastic holds disruptive potential if key steps advance this approach. Elucidating preneoplasia immunobiology progression risk modeling will be critical guide productive while mitigating immunotherapy hazards. Thoughtful translation could eventually shift paradigms priming immunosurveillance peak vulnerability lesions. Short Conclusion: Advancements may profoundly expand horizons. Cautious intercept toward widely disseminated malignancies. This warrants methodical efforts unravel promise thwarting lethal they start.

Language: Английский

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Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 19, 2024

In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by twelve traditional hallmarks aging. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these can be integrated with conventional aesthetic medicine techniques enhance skin rejuvenation. The potential combining targeted therapies against aging minimally invasive procedures represents significant advancement in medicine, offering personalized effective strategies combat reviewed evidence paves way for future advancements underscores transformative integrating scientifically validated into practices.

Language: Английский

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Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(S4), P. 5 - 14

Published: June 17, 2024

Abstract Senescence and epigenetic alterations are two important hallmarks of cellular aging. During aging, cells subjected to stress undergo many cycles damage repair before finally entering either apoptosis or senescence, a permanent state cell cycle arrest. The first biomarkers senescence be identified were increased ß‐galactosidase activity induction p16 INK4a . Another feature senescent is the senescence‐associated secretory phenotype (SASP), complex secretome containing more than 80 pro‐inflammatory factors including metalloproteinases, growth factors, chemokines cytokines. regulated through dynamic process involving self‐amplifying autocrine feedback loop activation immune system. Senescent play positive negative roles depending on composition their SASP may participate in various processes wound healing tumour suppression, as well regeneration, embryogenesis, tumorigenesis, inflammation also biomarker age, biological aging age‐related diseases. Recent advances anti‐age research have shown that can now prevented delayed by clearing mitigating effects which achieved healthy lifestyle (exercise diet), senolytics senomorphics, respectively. An alternative tissue rejuvenation, stimulating aged stem reprogramming deprogrammed cells. These non‐clinical findings will open up new avenues clinical into development treatments capable preventing treating pathologies humans.

Language: Английский

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Integrating Machine Learning with Multi-Omics Technologies in Geroscience: Towards Personalized Medicine

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 931 - 931

Published: Aug. 31, 2024

Aging is a fundamental biological process characterized by progressive decline in physiological functions and an increased susceptibility to diseases. Understanding aging at the molecular level crucial for developing interventions that could delay or reverse its effects. This review explores integration of machine learning (ML) with multi-omics technologies-including genomics, transcriptomics, epigenomics, proteomics, metabolomics-in studying hallmarks develop personalized medicine interventions. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis. Using ML analyze big complex datasets helps uncover detailed interactions pathways play role aging. The advances can facilitate discovery biomarkers therapeutic targets, offering insights into anti-aging strategies. With these developments, future points toward better understanding process, aiming ultimately promote healthy extend life expectancy.

Language: Английский

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From bench to bedside: translational insights into aging research

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 24, 2025

Aging research has rapidly advanced from fundamental discoveries at the molecular and cellular levels to promising clinical applications. This review discusses critical translational insights that bridge gap between bench bedside applications, highlighting key in mechanisms of aging, biomarkers, therapeutic interventions. It underscores importance interdisciplinary approaches collaboration among scientists, clinicians, policymakers address complexities aging improve health span.

Language: Английский

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Subtype-Specific Patterns of Tumor Purity and Mutation Load Suggest Treatment Implications

American Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Objectives: Sarcomas are complex mesenchymal malignancies whose molecular characteristics can significantly influence treatment strategies. This study aimed to investigate the relationship between tumor purity, mutation load, and clinical across sarcoma subtypes, focusing on potential implications for therapeutic stratification. Methods: analyzed of 7494 cases from Soft Tissue Bone Sarcoma (MSK, Nat Commun 2022) data set using available case analysis. Correlations age, sex were nonparametric methods, with subtype-specific analyses conducted Kruskal-Wallis tests Bonferroni-corrected post hoc comparisons. A comprehensive analysis patterns was performed microsatellite instability (MSI) status. Results: Significant correlations load purity (ρ=0.320, P <0.001) identified, marked heterogeneity subtypes. Tumor ranged 20.0% in brain sarcomas 78.5% dermatofibrosarcoma protuberans. Age-related changes observed (ρ=0.711, =0.006) skin (ρ=0.450, =0.006), suggesting distinct evolutionary patterns. subset hypermutated, stable (0.15%) loads exceeding 100 mutations/mb alternative mechanisms genomic instability. MSI-high status rare (0.24%) but associated higher (median: 25.84 vs. 2.42, <0.001), particularly uterine (0.7% prevalence). Conclusions: The identification subtypes challenge existing morphology-based classification systems may hold These findings help inform future immunotherapeutic molecular-guided approaches patients, elderly patients or females sarcomas.

Language: Английский

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The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 5, 2025

Language: Английский

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Epigenomic Echoes—Decoding Genomic and Epigenetic Instability to Distinguish Lung Cancer Types and Predict Relapse

Epigenomes, Journal Year: 2025, Volume and Issue: 9(1), P. 5 - 5

Published: Feb. 5, 2025

Genomic and epigenomic instability are defining features of cancer, driving tumor progression, heterogeneity, therapeutic resistance. Central to this process epigenetic echoes, persistent dynamic modifications in DNA methylation, histone modifications, non-coding RNA regulation, chromatin remodeling that mirror underlying genomic chaos actively influence cancer cell behavior. This review delves into the complex relationship between these illustrating how they collectively shape genome, affect repair mechanisms, contribute evolution. However, dynamic, context-dependent nature changes presents scientific ethical challenges, particularly concerning privacy clinical applicability. Focusing on lung we examine specific patterns function as biomarkers for distinguishing subtypes monitoring disease progression relapse.

Language: Английский

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