Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(4), P. 521 - 535

Published: March 30, 2024

Introduction Central nervous system (CNS)-related disorders are increasingly being recognized as a global health challenge worldwide. There significant challenges for effective diagnosis and treatment due to the presence of CNS barriers which impede management neurological diseases. Combination nanovesicles (NVs) magnetic nanoparticles (MNPs), referred (MNVs), is now well suggested potential theranostic option improving with increased targeting efficiency minimized side effects.

Language: Английский

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Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer’s disease: a comprehensive review of the characteristics and therapeutic strategies

Translational Neurodegeneration, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 26, 2025

Abstract Alzheimer’s disease (AD) is not a single-cause disease; rather, it complex neurodegenerative involving multiple pathological pathways influenced by various risk factors. Aggregation and accumulation of amyloid beta (Aβ) tau are the most prominent features in brains AD patients. Aggregated Aβ exert neurotoxic effects central nervous system, contributing to pathogenesis progression AD. They also act synergistically cause neurodegeneration, resulting memory loss. In this context, dual inhibition aggregation, or dissociation these two aggregates, considered promising for treatment. Recently, inhibitors capable simultaneously targeting aggregation both have been investigated. Specific amino acid domains associated with their aggregation/dissociation identified. Subsequently, therapeutic agents that prevent promote disaggregation identified/developed. review, we summarize major properties involved as well mechanisms regulate dissociation. This comprehensive review may contribute design discovery next-generation dual-targeting drugs tau, potentially leading development more effective strategies

Language: Английский

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Melittin induces autophagy to alleviate chronic renal failure in 5/6-nephrectomized rats and angiotensin II-induced damage in podocytes

Nutrition Research and Practice, Journal Year: 2024, Volume and Issue: 18(2), P. 210 - 210

Published: Jan. 1, 2024

Chronic renal failure (CRF) is a complex pathological condition that lacks cure. Certain Chinese medicines, such as melittin, major component in bee venom, have shown efficacy treating CRF patients. On the other hand, mechanisms underlying therapeutic effects of melittin are unclear.

Language: Английский

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L-arginine mitigates choroid plexus changes in Alzheimer’s disease rat model via oxidative/inflammatory burden and behavioral modulation

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102572 - 102572

Published: Sept. 24, 2024

Language: Английский

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Special Issue ‘Advances in Neurodegenerative Diseases Research and Therapy 2.0’

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4709 - 4709

Published: April 26, 2024

Neurodegenerative disorders (NDs) and the development of various therapeutic strategies to combat them have received increased attention in recent decades [...]

Language: Английский

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Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: 15(12), P. 997 - 1024

Published: Sept. 19, 2024

Neurological diseases, characterized by neuroinflammation and neurodegeneration, impose a significant global burden, contributing to substantial morbidity, disability mortality. A common feature of these disorders, including stroke, traumatic brain injury Alzheimer's disease, is the impairment blood-brain barrier (BBB), critical structure for maintaining homeostasis. The compromised BBB in neurodegenerative conditions poses challenge effective treatment, as it allows harmful substances accumulate brain. Nanomedicine offers promising approach overcoming this barrier, with nanoparticles (NPs) engineered deliver therapeutic agents directly affected regions. This review explores classification design NPs, divided into organic inorganic categories further categorized based on their chemical physical properties. These characteristics influence ability NPs carry release agents, target specific tissues ensure appropriate clearance from body. emphasizes potential enhance diagnosis treatment diseases through targeted delivery, improved drug bioavailability real-time efficacy monitoring. By addressing challenges targeting inflammatory biomarkers, represent cutting-edge strategy managing neurological better patient outcomes.

Language: Английский

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Unveiling the theranostic potential of SPIONs in Alzheimer's disease management

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 179, P. 244 - 256

Published: Sept. 20, 2024

Language: Английский

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