The Impact of the Natural Grass-Growing Model on the Development of Korla Fragrant Pear Fruit, as Well as Its Influence on Post-Harvest Sugar Metabolism and the Expression of Key Enzyme Genes Involved in Fruit Sugar Synthesis

Agriculture, Journal Year: 2025, Volume and Issue: 15(7), P. 792 - 792

Published: April 7, 2025

In this study, the effects of natural grass cultivation and clear on physiological characteristics Korla fragrant pear during fruit development storage were investigated, providing a scientific basis for high-quality cultivation. Sugar components, enzyme activities, gene expression levels in pulp peel comprehensively analyzed storage. A classification model was constructed using machine learning algorithms (RF, KNN, SVM), particle swarm optimization (PSO) employed to identify key factors. The results showed that significantly enhanced sugar accumulation fruits, particularly at 120 150 days after flowering, with fructose content increasing by 9.09 mg·g−1 12.59 mg·g−1, respectively, glucose also rising significantly. Additionally, promoted relative GK, PFK, FK genes pulp. During storage, activities group consistently higher than those across different periods, PFK activity being 23.73 U/L identified glyceraldehyde kinase, phosphofructokinase, fructokinase as factors influencing content. significant negative correlation observed between phosphofructokinase content, though relationship requires further investigation. This study elucidates regulatory mechanism which methods affect quality through photosynthetic product distribution. Our findings provide critical foundation are expected advance efficient industry, helping farmers improve both income.

Language: Английский

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Causal Associations of DNA Methylation and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study

Global Heart, Journal Year: 2024, Volume and Issue: 19(1), P. 48 - 48

Published: May 14, 2024

There is growing evidence that concentrations of DNA methylation are associated with cardiovascular disease; however, it unclear whether this association reflects a causal relationship.

Language: Английский

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Integrative multi-omics summary-based mendelian randomization identifies key oxidative stress-related genes as therapeutic targets for atrial fibrillation and flutter

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

Background Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with substantial morbidity and mortality. Oxidative stress (OS) has been implicated in the pathogenesis of AF, suggesting that targeting OS-related genes could offer novel therapeutic opportunities. This study aimed to identify causal contributing AF through comprehensive multi-omics Summary-based Mendelian Randomization (SMR) approach. Methods integrated data from genome-wide association studies (GWAS) methylation quantitative trait loci (mQTL), expression QTL (eQTL), protein (pQTL) explore relationships between oxidative stress-related (OS-related) risk. Genes were obtained Nielsen et al. (discovery) FinnGen (replication). The SMR analysis HEIDI test utilized assess associations, followed by Bayesian co-localization (PPH4 > 0.5) confirm shared variants. Multi-omics employed analyze associations within mQTL-eQTL pathways. A two-sample MR was conducted for sensitivity verification. significance findings determined using false discovery rate (FDR) < 0.05 p _HEIDI 0.01. Results At DNA level, 19 CpG sites near 7 unique found have effects on strong evidence support 0.70). gene six eQTLGen three GTEx (v8), including TNFSF10 , CDKN1A ALOX15 TTN PTK2 ALB KCNJ5 CASQ2 analyses 0.50). circulating both ALAD (OR 0.898, 95% CI 0.845–0.954, PPH4 = 0.67) APOH 0.896, 0.844–0.952, 0.93) lower risk validated replication group. After integrating mQTL eQTL, we identified two genes, . cg09915519 cg10087519 higher which aligns negative effect may play protective role AF. Conclusion several particularly TTN, as having roles verified across three-omics underscore importance these highlight their potential targets. integration provides understanding molecular mechanisms underlying paving way targeted strategies.

Language: Английский

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Genetic Basis of Hypertrophic Cardiomyopathy in Cats

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8752 - 8766

Published: Aug. 12, 2024

Hypertrophic cardiomyopathy (HCM) is a common cardiovascular condition in cats, affecting yth males and females of all ages. Some breeds, such as Ragdolls Maine Coons, can develop HCM at young age. The disease has wide range progression severity, characterized by various pathological changes the heart, including arteritis, fibrous tissue deposition, myocardial cell hypertrophy. Left ventricular hypertrophy, which restrict blood flow, feature HCM. may persist into old age eventually lead to heart failure increased diastolic pressure. basis cats thought be genetic, although exact mechanisms are not fully understood. Mutations sarcomeric proteins, particular myosin-binding protein C (MYBPC3), have been identified with Two specific mutations, MYBPC3 [R818W] [A31P], classified ‘pathogenic’. Other variants genes MYBPC3, TNNT2, ALMS1, MYH7 also associated However, there cases where without known genetic mutations still HCM, suggesting presence unknown factors contributing disease. This work aims summarise new knowledge alterations cardiac result variants.

Language: Английский

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Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?

Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1732 - 1732

Published: Oct. 18, 2024

Resveratrol (RES) is a polyphenol with natural anti-inflammatory and antioxidant properties. It found in abundance plants, i.e., grapes mulberry fruit. In addition, synthetic forms of RES exist. Since the discovery its specific biological properties, has emerged as candidate substance not only modeling effects on immune response but also an important factor preventing onset progression cardiovascular disease (CVD). Previous research provided strong evidence platelets, mitochondria, cardiomyocytes, vascular endothelial function. positively affects coagulation system vasodilatory function improves blood flow. Not humans veterinary medicine, diseases have one highest incidence rates. Canine human species co-evolved share recent evolutionary selection processes, interestingly, numerous pathologies companion dogs counterpart. Knowledge impact becoming clearer literature. Dogs long been recognized valuable animal models for study various they many physiological genetic similarities humans. this review, we aim to shed light pleiotropic resveratrol health translational model diseases.

Language: Английский

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Correlation between Electrocardiogram Changes and Right Ventricular Systolic Function in Patients with Chronic Atrial Fibrillation

The Heart Surgery Forum, Journal Year: 2024, Volume and Issue: 27(5), P. E528 - E532

Published: May 19, 2024

Background: Chronic atrial fibrillation (CAF) induces various electric disturbances, and a single mutation can cause multifarious phenotypes or combinations. Identifying the correlation of electrocardiogram changes corresponding to disorders electrical activity with right ventricular systolic function (RVSF) is important for treatment prognosis CAF. Therefore, this study explored RVSF in patients Methods: From March 2022, 2023, 97 CAF admitted Department Cardiology our hospital (study group) 100 normal people who received health examination (control were subjected echocardiogram record relevant parameters analysis. Results: Significant differences found indices heart between two groups. The group had significantly higher rate, QTc interval, QT interval T wave time than control (p < 0.05). showed end-diastolic volume (RVEDV) end-systolic (RVESV), lower stroke (RVSV) ejection fraction (RVEF) Pearson analysis that positively correlated RVESV 0.05); negatively RVSV was RVEF Conclusion: A exists

Language: Английский

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