The Use of Compounds Derived from Cannabis sativa in the Treatment of Epilepsy, Painful Conditions, and Neuropsychiatric and Neurodegenerative Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5749 - 5749

Published: May 25, 2024

Neurological disorders present a wide range of symptoms and challenges in diagnosis treatment. Cannabis sativa, with its diverse chemical composition, offers potential therapeutic benefits due to anticonvulsive, analgesic, anti-inflammatory, neuroprotective properties. Beyond cannabinoids, cannabis contains terpenes polyphenols, which synergistically enhance pharmacological effects. Various administration routes, including vaporization, oral ingestion, sublingual, rectal, provide flexibility treatment delivery. This review shows the efficacy managing neurological such as epilepsy, neurodegenerative diseases, neurodevelopmental disorders, psychiatric painful pathologies. Drawing from surveys, patient studies, clinical trials, it highlights alleviating symptoms, slowing disease progression, improving overall quality life for patients. Understanding mechanisms can open up possibilities using this plant individual needs.

Language: Английский

---

The Effects of Indirect and Direct Modulation of Endocannabinoid System Function on Anxiety-Related Behavior in Mice Assessed in the Elevated Plus Maze Test

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 867 - 867

Published: Feb. 13, 2025

The endocannabinoid system (ECS) is one of the most important systems modulating functions in body. ECS, via cannabinoid (CB: CB1 and CB2) receptors, endocannabinoids occurring brain (e.g., anandamide (AEA) 2-arachidonoylglycerol (2-AG)) enzymes degrading (fatty-acid amide hydrolase (FAAH) monoacylglycerol lipase (MAGL)), plays a key role regulation mood anxiety. However, effects compounds on anxiety-related responses are complex yield mixed results depending type pharmacological manipulation (direct or indirect) as well kinds cannabinoids, dosage procedure. aim this study was to determine compare influence direct (via CB receptors ligands) indirect inhibition brain) modulation ECS function anxiety-like mice elevated plus maze (EPM) test. For purpose, first step experiments, we used selected ligands CB1, CB1/CB2 CB2 assess which types involved mice. Next, inhibitors FAAH (which breaks down AEA) MAGL 2-AG) more responsible for behavior our presented research showed that an acute administration receptor agonist oleamide (5-20 mg/kg) had no antagonist AM 251 (0.25-3 anxiogenic EPM test In turn, WIN55,212-2 at dose 1 mg/kg anxiolytic effect observed What interest both (JWH 133 doses 2 (AM 630 0.5-2 Moreover, revealed only inhibitor URB 597 (0.3 effect, while JZL 184 (at any (2-40 mg/kg)) after injection anxiety mice, confirmed clearly significant involvement responses. particular, able elicit promising effects. Therefore, could be potential target novel drugs; however, further studies needed.

Language: Английский

---

Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that regulates secretion along the hypothalamic-pituitary-adrenal (HPA) axis, mediates neurotransmission humoral regulation. Due widespread expression of receptors (GR), effects CORT are almost ubiquitous in various tissue cells. Therefore, on one hand, is molecular signal activates body’s system during other due chemical properties GCs, anti-inflammatory act as stabilizers control response stress. Inflammation manifestation activation. plays dual roles this process both promoting inflammation exerting As hormone, levels fluctuate with degree duration stress, determining its changes it induces. essential for resist diseases maintain homeostasis, imbalance being key factor development diseases. understanding role mechanisms action immunity crucial. This review addresses important issue summarizes interactions between system.

Language: Английский

---

The interaction of Suk-Saiyasna remedy with GABAA and CB1 receptor-targeting drugs: Enhancing hypnotic and sedative effects in in vivo models

Journal of Advanced Pharmaceutical Technology amp Research, Journal Year: 2024, Volume and Issue: 15(1), P. 13 - 18

Published: Jan. 1, 2024

A BSTRACT The Suk-Saiyasna remedy, an herbal treatment, was historically used but ceased due to its cannabis content. After a relaxation of drug control laws in Thailand, use re-emerged. This study examines the remedy’s impact on rodent behavior and receptor effects. conducted assess sedative-like effects remedy mice. mice were divided into groups receiving 0.6, 3, 30, 60 mg/kg extracts, with negative controls for comparison. We also investigated receptors, utilizing pretreatment blockers, followed by either or extract. Furthermore, this behavioral aspects mice, including anxiolytic effects, antidepressant-like motor coordination, elevated plus-maze, open-field, rotarod performance tests. ( P < 0.05) decreased significantly latent period increased sleeping time treated groups. Moreover, showed efficacy reaction GABAA receptors cannabinoid CB1 0.05). In addition, positive observed regarding animal arena, as activity, behavior, muscle coordination reduced may be involved sedative–hypnotic-like effect rodents under normal conditions through modulation GABAergic neurons induction mechanism.

Language: Английский

---

Maxdo and RDF55v are Crucial Molecular Descriptors Governing the Cannabinoid Receptor 1(CB1) Modulator Activity of N, N'-diphenyl Urea Analogs and 1H-Indole-2-carboxamides

Oriental Journal Of Chemistry, Journal Year: 2024, Volume and Issue: 40(5), P. 1426 - 1439

Published: Oct. 31, 2024

CB1 allosteric modulators such as synthetic cannabinoids are promising therapeutic agents. Among the various receptor modulators, indole-2-carboxamides, and N, N'-diphenyl urea derivatives continuously explored for their potency selectivity towards receptor. In present computational work, QSAR models were generated using Drug Theoretics Chemoinformatics (DTC tools) tools to analyze influence of molecular features these (one hundred fourteen compounds) on activity. A statistically significant three-parameter model (SPMin2_Bhm, maxdO, minssN) was derived that displayed R2 Q2 values 0.66 0.62, respectively. SPMin2_Bhm maxdO negatively correlated with activity, whereas minssN has a positive connection. seven-parameter (maxdO, minsssN, RDF55v, VE3_D, minHBint10, SpMin5_Bhs, CrippenLogP) also obtained 0.76 0.70, The findings might assist in design development novel based structures indole-2-carboxamides

Language: Английский

---

The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1285 - 1285

Published: Dec. 21, 2024

Substance use disorders (SUDs) and anxiety (ADs) are highly comorbid, a co-occurrence linked to worse clinical outcomes than either condition alone. While the neurobiological mechanisms involved in SUDs intensively studied separately, underlying their comorbidity remain an emerging area of interest. This narrative review explores processes this comorbidity, using Research Domain Criteria (RDoC) framework map disruptions positive valence, negative cognitive systems across three stages addiction cycle: binge/intoxication, withdrawal/negative affect, preoccupation/anticipation. Anxiety substance play reciprocal role at each stage addiction, marked by significant psychosocial impairment dysregulation brain. A more thorough understanding neural underpinnings comorbid will contribute tailored effective therapeutic interventions assessments.

Language: Английский

---

Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 689 - 689

Published: May 27, 2024

Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly illegal, its production mostly uncontrolled, and idea medical incipient only. We hypothesized that recent changes in attitudes legislations may have favorably affected research. In addition, publication bias against also decreased. To investigate this hypothesis, we conducted a review research published over last three years. found 156 relevant articles. most cross-sectional studies, depression higher those who consumed than did not. An increase consumption typically followed by an depression, whereas withdrawal from ameliorated cases. Although reduced none these placebo-controlled. clinical same period, placebo and, average effect size larger investigated plausibility antidepressant reviewing molecular pharmacological studies. Taken together, reviewed do not support herbal

Language: Английский

---

The Interplay of Exogenous Cannabinoid Use on Anandamide and 2-Arachidonoylglycerol in Anxiety: Results from a Quasi-Experimental Ad Libitum Study

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1335 - 1335

Published: Oct. 6, 2024

The public is increasingly reporting using cannabis for anxiety relief. Both use and the endocannabinoid system have been connected with relief/anxiolytic properties, but these relationships are complex, underlying mechanisms them unclear.

Language: Английский

---

Health-related Messages about Herbs, Spices and Other Botanicals Appearing in Print Issues and Websites of Legacy Media: Content Analysis and Evaluation (Preprint)

JMIR Formative Research, Journal Year: 2024, Volume and Issue: 8, P. e63281 - e63281

Published: Nov. 5, 2024

Background Legacy media are publications that existed before the internet. Many of these have migrated to a web format, either replacing or in parallel their print issues. Readers place an economic value on access information presented as they pay for subscriptions and higher degree trust content. Much has been written about inaccurate misleading health social media; however, content accuracy contained legacy not examined detail. Discussion herbs, spices, other botanicals absent from this context. Objective The objectives study were (1) identify associations botanical products mentioned targeted range demographic groups (2) evaluate against published scientific studies. Methods In total, 10 popular magazines targeting gender, race/ethnicity, sexual orientation selected analysis. Relevant was extracted coded over 1 year. Associations between specific factors identified. For most frequent botanical–health application associations, PubMed search conducted reviews corresponding each item’s indicated applications. Where no systematic available, single research studies sought. Results A total 237 unique There 128 mentions issues 1215 websites. 18 applications identified used categorize uses various individually general categories. frequently skin care, with 913 mentions, immunity enhancement, 705 gastrointestinal probiotics, 184 cognitive function (stress mental health), 106 mentions. Comparison literature evaluating efficacy functions positive support aloe vera, argan oil, chamomile, jojoba lavender, rosemary, tea tree oil care. Berries, ginger, turmeric, green had strongest evidence role enhancement. Ginger oats supported having health. Finally, berries, ashwagandha, cannabidiol managing stress. Other items such mushrooms less strongly supported. Conclusions prevalent indicates that, overall, consistent current reports products. While some greater than others, truly egregious falsehoods absent. Therefore, may be considered credible source readers topics.

Language: Английский

---

Health-Related Messages About Herbs, Spices, and Other Botanicals Appearing in Print Issues and Websites of Legacy Media: Content Analysis and Evaluation (Preprint)

Published: June 14, 2024

Legacy media are publications that existed before the internet. Many of these have migrated to a web format, either replacing or in parallel their print issues. Readers place an economic value on access information presented as they pay for subscriptions and higher degree trust content. Much has been written about inaccurate misleading health social media; however, content accuracy contained legacy not examined detail. Discussion herbs, spices, other botanicals absent from this context. The objectives study were (1) identify associations botanical products mentioned targeted range demographic groups (2) evaluate against published scientific studies. In total, 10 popular magazines targeting gender, race/ethnicity, sexual orientation selected analysis. Relevant was extracted coded over 1 year. Associations between specific factors identified. For most frequent botanical–health application associations, PubMed search conducted reviews corresponding each item’s indicated applications. Where no systematic available, single research studies sought. A total 237 unique There 128 mentions issues 1215 websites. 18 applications identified used categorize uses various individually general categories. frequently skin care, with 913 mentions, immunity enhancement, 705 gastrointestinal probiotics, 184 cognitive function (stress mental health), 106 mentions. Comparison literature evaluating efficacy functions positive support aloe vera, argan oil, chamomile, jojoba lavender, rosemary, tea tree oil care. Berries, ginger, turmeric, green had strongest evidence role enhancement. Ginger oats supported having health. Finally, berries, ashwagandha, cannabidiol managing stress. Other items such mushrooms less strongly supported. prevalent indicates that, overall, consistent current reports products. While some greater than others, truly egregious falsehoods absent. Therefore, may be considered credible source readers topics.

Language: Английский

---