Cited by Chromium Affects Mitochondrial Function, Leading to Apoptosis and Autophagy in Turtle Primary Hepatocytes

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress DOI

Tiantian Guo,

Xiren Geng,

Yue Zhang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103674 - 103674

Published: March 16, 2024

Microplastics biological toxicity, environmental persistence and chemicals have been paid widespread attention. exposed to chicken spleen injury of the specific mechanism is unclear. Thus, we randomly assigned chickens 4 groups: C (normal diet), L-MPs (1 mg/L), M-MPs (10 H-MPs (100 assessed damage after 42 d exposure. Morphologically, boundary between red white pulp was blurred, along with expansion pulp. It further speculated that microplastics induced mitochondrial dynamic homeostasis (Drp1 upgraded, Mfn1, Mfn2, OPA1 reduced), provoked apoptotic pathway (Bcl-2/Bax decreased, cytc, caspase3, caspase9 raised), resulting in redox imbalance lipid peroxide accumulation (MDA increased, CAT, GSH, T-AOC plummeted), stimulated ferroptosis (FTH1, GPX4, SLC7A11 decreased). Here explored impact polystyrene on spleen, as well programmed death (apoptosis ferroptosis) involved, regulative role mitochondria this process. This could be significant importance bridging gap laboratory research microplastics-induced chicken.

Language: Английский

Citations

The Essential Role of Mitochondrial Dynamics in Viral Infections DOI

Xujie Duan, Rui Liu, Wenjun Lan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1955 - 1955

Published: Feb. 24, 2025

Mitochondria are dynamic organelles that play crucial roles in energy production, metabolic balance, calcium homeostasis, apoptosis, and innate immunity, key determinants of cell fate. They also targets for viral invasion the body. Many proteins target mitochondria, controlling mitochondrial morphology, metabolism, immune response, thereby achieving evasion, promoting their proliferation, accelerating infection process. Mitochondrial quality control is to maintaining normal physiological functions homeostasis. Dysregulation dynamics closely related development many diseases. New constantly being discovered. Viruses change by targeting mitochondria achieve a persistent state infection. Currently, understanding during limited. Research on impact provides foundation investigating pathogenesis infections, disease process, identifying potential therapeutic targets. This review focuses connection between priority areas research virus-mediated insight into regulation viruses explores means mitochondrial-mediated treatment

Language: Английский

Citations

Disturbance of Mitochondrial Dynamics Led to Spermatogenesis Disorder in Mice Exposed to Polystyrene Micro- and Nanoplastics DOI

Moxuan Zhao,

Junhong Xie, Jiaxiang Zhang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 362, P. 124935 - 124935

Published: Sept. 10, 2024

Language: Английский

Citations

An Overview of Hexavalent Chromium-Induced Necroptosis, Pyroptosis, and Ferroptosis DOI

Saulesh Kurmangaliyeva,

Kristina Baktikulova,

Viktoriya Tkachenko

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

Mitochondrial remodelling supports migration in white-crowned sparrows ( Zonotrichia leucophrys ) DOI

Paulo H. C. Mesquita, E. A. Rhodes, Kang Nian Yap

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 291(2036)

Published: Dec. 1, 2024

The migratory movements undertaken by birds are among the most energetically demanding behaviours observed in nature. Mitochondria source of aerobic energy production on which migration depends, but a key component mitochondrial function, remodelling, has not been investigated context bird migration. We measured markers remodelling skeletal muscles Gambel's (migratory) and Nuttall's (non-migratory) white-crowned sparrows within outside periods. were collected (i) non-migration period (baseline), (ii) preparation to depart for spring (pre-migration) (iii) active autumn (mid-migration). at timepoints corresponding baseline mid-migration Gambel's. Across all sampling periods, we found that had greater compared with non-migratory birds. Furthermore, from population also displayed flexibility, increasing several (e.g. NRF1, OPA1 Drp1) pre- during Further, levels its upregulation specific pectoralis muscle used flapping flight. Our study is first show supports sparrows, indicating highly efficient phenotype supporting increased energetic demands

Language: Английский

Citations

Inflammation as a pathway for heavy metal-induced liver damage—Insights from a repeated-measures study in residents exposed to metals and bioinformatics analysis DOI

Shuanzheng Zhao,

Guohuan Yin,

Meiduo Zhao

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2024, Volume and Issue: 261, P. 114417 - 114417

Published: July 4, 2024

Language: Английский

Citations

Chromium Affects Mitochondrial Function, Leading to Apoptosis and Autophagy in Turtle Primary Hepatocytes DOI

Shuqin Lin,

Yunjuan Xiao,

Jing Lin

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(16), P. 2403 - 2403

Published: Aug. 19, 2024

Hexavalent chromium (Cr(VI)), a pervasive industrial contaminant, is highly toxic to both humans and animals. However, its effects on turtles are largely unexplored. Our study aimed investigate the of Cr(VI) Reeves' (

Language: Английский

Citations