Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease DOI Creative Commons

Elisabet Coll,

Secundino Cigarrán Guldris, José Pórtoles

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 495 - 495

Published: Nov. 17, 2024

The gut dysbiosis present in chronic kidney disease (CKD) has been associated with anemia. Factors such as the accumulation of gut-derived uremic toxins, increased barrier permeability-induced inflammation, and a reduced intestinal production short-chain fatty acids (SCFAs), all changes microbiota composition CKD, may lead to development or worsening anemia renal patients. Understanding addressing these mechanisms related CKD patients can help delay improve its control this population. One approach is avoid reduce use drugs linked phosphate binders, oral iron supplementation, antibiotics, others, unless they are indispensable. Another involves introducing dietary that promote healthier and/or using prebiotics, probiotics, symbiotics setting. These measures increase presence SCFA-producing saccharolytic bacteria proteolytic bacteria, thereby lowering toxins inflammation. By ameliorating CKD-related dysbiosis, strategies also enhance response erythropoiesis-stimulating agents (ESAs) ESA-resistant In review, we have explored relationship between propose feasible solutions, both those already known potential future treatments.

Language: Английский

Optimization and purification of antimicrobial peptide HI produced by fermentation of Lactococcus lactis NZ9000/HI and its potential in pork preservation DOI Creative Commons
Mingyang Hu,

Yuwen Li,

Lu Zhao

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117342 - 117342

Published: Jan. 1, 2025

Language: Английский

Citations

2
Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI Open Access

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

Citations

12
The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency DOI Open Access
George J. Kontoghiorghes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4654 - 4654

Published: April 25, 2024

The supply and control of iron is essential for all cells vital many physiological processes. All functions activities are expressed in conjunction with iron-binding molecules. For example, natural chelators such as transferrin chelator–iron complexes haem play major roles metabolism human physiology. Similarly, the mainstay treatments most common diseases metabolism, namely deficiency anaemia overload, involve iron–chelator iron-chelating drugs deferiprone (L1), deferoxamine (DF) deferasirox. Endogenous citric acid glutathione exogenous ascorbic also important homeostasis. Recent advances treatment effective ferric tri-maltol complex (feraccru or accrufer) transfusional overload using L1 L1/DF combinations have decreased associated mortality morbidity improved quality life millions patients. Many other chelating ciclopirox, dexrazoxane EDTA used daily by patients diseases. their metabolites iron-chelation capacity hydroxyurea, tetracyclines, anthracyclines aspirin, well dietary molecules gallic acid, caffeic quercetin, ellagic maltol phytochelators, known to interact affect related Different interactions observed presence essential, xenobiotic, diagnostic theranostic metal ions competing iron. Clinical trials Parkinson’s, Alzheimer’s neurodegenerative diseases, HIV infections, cancer, diabetic nephropathy inflammation, highlight importance chelation therapy clinical conditions. proposed use modulating ferroptosis signifies a new era design therapeutic strategies introduction artificial intelligence guidance optimal outcomes personalised medicine expected increase further impact medicine, survival metabolic disorders

Language: Английский

Citations

8
Evaluation of oyster peptide-chitosan oligosaccharide-iron complex (OPCFe) complex as a novel approach for iron supplementation: Effects on oxidative stress, inflammation, and gut microbiota in vivo DOI

Xuening Yu,

Guang Li, Xiaoyang Liu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106007 - 106007

Published: Jan. 1, 2025

Language: Английский

Citations

0
Role of Metabolism in Supporting Immune Responses DOI
Shriraj Susarla, Muhammed İbrahim Erbay,

Amit Johanis

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome DOI Open Access
Laura Childers, Jieun Park, Siyao Wang

et al.

Published: Feb. 10, 2025

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do not affect number absorbing LRE cells, lower expression endocytic digestion machinery transgene assisted cell isolation single RNA-sequencing, characterize all cells take up dietary protein. We bacteria-sensing metabolic pathways LREs, some secretory types share components with custom-formulated diets, investigated influence diet activity microbiome. Impaired along protein-deficient diet, alters microbial community leads increased abundance bacterial genera have capacity reduce Together, these results reveal diet-dependent reciprocal interactions LREs regulate absorption.

Language: Английский

Citations

0
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome DOI Creative Commons
Laura Childers, Jieun Park, Siyao Wang

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: March 13, 2025

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome-rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do not affect number absorbing LRE cells, lower expression endocytic digestion machinery transgene-assisted cell isolation single RNA-sequencing, characterize all cells take up dietary protein. We bacteria-sensing metabolic pathways LREs, some secretory types share components with custom-formulated diets, investigated influence diet activity microbiome. Impaired along protein-deficient diet, alters microbial community leads an increased abundance bacterial genera have capacity reduce Together, these results reveal diet-dependent reciprocal interactions LREs regulate absorption.

Language: Английский

Citations

0
Iron overload exacerbates metabolic dysfunction-associated steatohepatitis via the microbiota-gut-liver axis through lipopolysaccharide-mediated Akr1b8 activation DOI
Han Yu, Yuhui Zhang, Jianjun Chen

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome DOI Creative Commons
Laura Childers, Jieun Park, Siyao Wang

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Oct. 30, 2024

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome-rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do not affect number absorbing LRE cells, lower expression endocytic digestion machinery transgene-assisted cell isolation single RNA-sequencing, characterize all cells take up dietary protein. We bacteria-sensing metabolic pathways LREs, some secretory types share components with custom-formulated diets, investigated influence diet activity microbiome. Impaired along protein-deficient diet, alters microbial community leads an increased abundance bacterial genera have capacity reduce Together, these results reveal diet-dependent reciprocal interactions LREs regulate absorption.

Language: Английский

Citations

3
Sialylation in the gut: From mucosal protection to disease pathogenesis DOI

Xueni Ma,

Muyang Li, Xiaochun Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122471 - 122471

Published: July 9, 2024

Language: Английский

Citations

2