Trends in research on novel antidepressant treatments

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Mood disorders, such as major depressive disorder and bipolar disorder, are among the most common mental illnesses a leading cause of disability worldwide. Key symptoms these conditions include depressed mood or anhedonia, sleep psychomotor disturbances, changes in appetite weight, fatigue loss energy. Prolonged cognitive disturbances further impair ability to think concentrate often accompanied by persistent feelings worthlessness excessive guilt. Collectively, underscore depression serious, long-term global health issue. In addition, clinical studies indicate growing number patients experiencing difficulties responding treatment, even long term. This phenomenon poses significant challenges for healthcare professionals, families, alike. As result, there is an urgent need therapies that both rapid-acting safe. review aims summarize prevailing trends research on novel antidepressants, emphasizing their diversity multi-directional mechanisms action. The development drugs increasingly focused achieving high efficacy, particularly treatment-resistant depression. Such advances offer potential rapid therapeutic effects without prolonged tedious administration older generation antidepressants. Findings from using animal models continue play crucial role predicting designing new strategies. These remain indispensable understanding physiological newly developed compounds, thereby guiding creation innovative treatments.

Language: Английский

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Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10398 - 10447

Published: May 10, 2024

Language: Английский

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Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety- and depressive-like behaviors in the ulcerative colitis mice

Neurochemistry International, Journal Year: 2024, Volume and Issue: 178, P. 105789 - 105789

Published: June 7, 2024

Language: Английский

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The efficacy and safety of auricular acupoint therapy on treating functional dyspepsia with insomnia: study protocol for a randomized controlled trial

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 12, 2025

Background Functional dyspepsia (FD) is a prevalent health issue currently lacking optimal treatment options, with its global incidence rate increasing in recent years. Clinical studies have recently focused on the application of auriculotherapy functional gastrointestinal disorders that are accompanied by negative emotions. However, few randomized controlled trials investigated use for FD patients insomnia, leaving therapeutic efficacy and safety largely undefined. This study aims to evaluate clinical treating insomnia. Methods analysis single-center, trial involving 80 Using central randomization system, subjects randomly assigned auricular acupressure group or sham at 1:1 ratio, targeting concha region earlobe region. The primary outcome response 2 weeks, secondary outcomes include 8 sleep data assessed actigraphy, modified Dyspepsia Symptom Diary, short form-Nepean Index, Self-rated Anxiety Scale, Depression High Arousal Heart Rate Variability. Efficacy results will be evaluated baseline weeks after treatment. Adverse events monitored throughout observation period. Discussion this anticipated validate improving symptoms as well reducing emotional states. registration ClinicalTrials.gov , NCT06466044. Registered 14th May 2024, https://register.clinicaltrials.gov .

Language: Английский

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Early Target Identification for Symptomatic Intervention in Radiotherapy in Patients with Esophageal Cancer: A Longitudinal Cross-lagged Panel Dynamic Network Analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Background Predictive identification of core symptoms in patients with esophageal cancer undergoing radiotherapy is essential for early symptom prevention. Few studies address dynamic prediction using longitudinal network analysis. Objectives This study aimed to establish predictive relationships between and identify intervention targets by constructing a network. Methods prospective enrolled 146 from June 2023 May 2024. Data were collected the M.D. Anderson Symptom Inventory Gastrointestinal Cancer Module Hospital Anxiety Depression Scale at three points: T0(pre-radiotherapy), T1(mid-radiotherapy), T2(1-month post-radiotherapy). R software was used construct cross-lagged panel networks calculate centrality indices. Results Distress had most substantial outgoing influence. At T0→T1, distress predicted anxiety, depression, disturbed sleep. T1→T2, loss appetite. depression affected while sleep appetite T1→T2. Dry mouth significantly aggravated T1, dry showing strongest bridging effect T0→T1. Drowsiness highest Conclusions should be targeted reduce anxiety improve quality physical condition post-radiotherapy. Clinicians dynamically manage drowsiness during prevent crosstalk. Implications survivorship Managing psycho-emotional states before critical preventing other symptoms. Active pharmacologic non-pharmacologic interventions are needed radiotherapy.

Language: Английский

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Investigating the mechanistic role of oxidative stress in brain–gut axis disruption in rat model

Academia Biology, Journal Year: 2024, Volume and Issue: 2(4)

Published: Nov. 12, 2024

Language: Английский

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