Gene, Journal Year: 2024, Volume and Issue: unknown, P. 149165 - 149165
Published: Dec. 1, 2024
Language: Английский
Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 51 - 51
Published: Jan. 2, 2025
Polycystic ovary syndrome (PCOS) is the most common endocrine metabolic disorder found in women of reproductive age and characterized by both dysfunction. Women with PCOS commonly have insulin resistance, increased susceptibility to type 2 diabetes mellitus, dyslipidemia, hyperinsulinemia, cardiovascular risk, hepatic steatosis, infertility, an overall reduction physical psychological well-being. Several previous studies shown a causal association between disorders, such as chronic liver disease (CLD) nonalcoholic fatty (NAFLD), where was identified contributing features. Whilst it recognized that may contribute dysfunction, there also evidence features PCOS. The purpose this review discuss current understanding regarding involvement pathophysiology, inflammatory markers hepatokines involved development PCOS, role genetics occurrence This illustrates NAFLD are disorders genetic linkage disorders. As such, whilst development, converse be case, potential bidirectional relationship disease.
Language: Английский
Citations
1
Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101895 - 101895
Published: Jan. 18, 2025
Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, satiety. We examine compelling evidence supporting GLP-1 receptor agonists (GLP-1RAs) managing type 2 diabetes (T2D), obesity, other The intricate molecular mechanisms underlying GLP-1RAs are explored, including their interactions with pathways extracellular signal-regulated kinase 1/2 (ERK1/2), activated protein (AMPK), cyclic adenine monophosphate (cAMP), mitogen-activated (MAPK), C (PKC). Expanding our understanding, investigates potential role cancers. Also, microribonucleic acid (RNA) (miRNAs), critical regulators gene expression, introduced modulators signaling. delve link between miRNAs T2D obesity explore specific miRNA examples influencing GLP-1R function. Finally, explores rationale seeking alternatives to highlights natural products modulatory effects.
Language: Английский
Citations
1
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234
Published: May 20, 2024
Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.
Language: Английский
Citations
8
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 7, 2025
Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by dysfunction and metabolic abnormalities. The purpose of this study was to explore the expression characteristics coding non-coding RNAs in granulosa cells PCOS, provide data support for understanding pathogenesis PCOS. Three patients with PCOS (according 2003 Rotterdam diagnostic criteria) three normal controls were selected. We used standard long protocol collect from two groups, who underwent assisted reproduction at Reproductive Medicine Center Affiliated Hospital Inner Mongolia Medical University, China. performed whole-transcriptome sequencing using RNA-Seq technology construct transcriptome patterns messenger (mRNAs), (lncRNAs), circular (circRNAs), microRNAs (miRNAs). These then subjected in-depth analysis bioinformatics tools. identified total 2111 mRNAs 4328 (ncRNAs) group as compared control group. Among ncRNAs, there 2047 lncRNAs, 892 circRNAs, 1389 miRNAs. Based on condition |log2(fold_change) |≥ 1 P-value ≤ 0.05, we obtained 705 differentially expressed genes (DEGs), 204 111 88 target mainly enriched pathways such mitogen-activated protein kinase (MAPK), Wnt, transforming growth factor-beta (TGF-β), cell cycle. There types among which number exon-type circRNAs accounted more than 90%. Using co-expression network analysis, several important candidate gene (VLDLR, PPP2R2B, MYOCD), lncRNAs (FBXO30, SNHG14, PVT1), miRNAs (miRNA-150); these ncRNAs could play regulatory role cells. In study, discovered significant alterations mRNAs, cells, indicating dysregulation vital pathways. Notably, like VLDLR, MYOCD, along FBXO30, PVT1, may contribute pathology, shedding light potential therapeutic targets.
Language: Английский
Citations
0
Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112492 - 112492
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123296 - 123296
Published: March 1, 2025
Language: Английский
Citations
0
Life Sciences, Journal Year: 2024, Volume and Issue: 359, P. 123221 - 123221
Published: Nov. 8, 2024
Language: Английский
Citations
3
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 24, 2024
Recent evidence has demonstrated that abnormal expression and regulation of circular RNA (circRNAs) are implicated in the development progression various tumors. The aim this study was to investigate effects circ_SMA4 Gastrointestinal Stromal Tumors (GISTs) malignant progression. Human circRNAs microarray analysis conducted identify differentially expressed (DE) GISTs. effect on cell proliferation, invasion, migration, apoptosis assessed both vitro vivo settings. Dual-luciferase reporter assay, RT-qPCR, Western-blot, rescue assay were employed confirm interaction between circ_SMA4/miR-494-3p/ KIT axis. results revealed significantly upregulated GISTs, exhibited high diagnostic efficiency with an AUC 0.9824 (P < 0.01). promoted while inhibiting GISTs cells, vivo. Silencing partially inhibited Additionally, acted as a competing endogenous (ceRNA) by targeting miR-494-3p, identified functional gene for miR-494-3p Furthermore, confirmed axis plays role activating JAK/STAT signaling pathway Therefore, first time, we have emphasized is oncogenic sponging activate KIT/JAK/STAT pathway. These findings underscore may serve novel biomarker therapeutic target
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12979 - 12979
Published: Dec. 3, 2024
The study of microRNAs (miRNAs) has emerged in recent decades as a key approach to understanding the pathophysiology many diseases, exploring their potential role biomarkers, and testing use future treatments. Not only have neurological, cardiovascular or cancer benefited from this research but also infertility. Female infertility, disease, involves alterations at multiple levels, such ovarian uterine alterations. This review compiles latest studies published humans that link female disorders affect fertility with altered miRNA profiles. Studies on alterations, including diminished reserve (DOR), poor response stimulation (POR), premature insufficiency (POI), polycystic ovary syndrome (PCOS), are summarized classified based expression type sample analyzed. Regarding disorders, highlights upregulated downregulated miRNAs primarily identified biomarkers for endometriosis, adenomyosis, decreased endometrial receptivity, implantation failure. However, despite large number field, same limitations reduce reproducibility often observed. Therefore, end review, main described, well specific precautions safety measures should be considered when handling miRNAs.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36321 - e36321
Published: Aug. 1, 2024
Polycystic ovary syndrome (PCOS) is the most common and multifactorial endocrine disease among women of reproductive age. Aberrant folliculogenesis a pathological characteristic PCOS, but underlying molecular mechanism remains unclear. Emerging evidence indicated that aberrant expression long noncoding RNAs (lncRNAs) may contribute to pathogenesis PCOS. In this study, we found lncRNA PKD1P6 was remarkably down-regulated in ovarian granulosa cells (GCs) hyperandrogenic PCOS (HA-PCOS) patients negatively correlated with serum testosterone (T) levels. We further showed overexpression markedly reduced cell viability, attenuated DNA synthesis capacity, arrested cycle at G0/G1 phase promoted apoptosis KGN cells. Exosomes derived from exerted similar effects on function Mechanistically, could act as competing endogenous RNA (ceRNA) by directly binding miR-135b-5p. Overexpression significantly suppressed ERK1/2 activation, whereas up-regulation miR-135b-5p an opposing effect. Additionally, excessive androgen diminish while promote models vitro vivo. Collectively, our findings delineate clinical significance HA-PCOS new regulatory mechanisms involved abnormal folliculogenesis, providing promising therapeutic target for HA-PCOS.
Language: Английский
Citations
1