International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 241 - 241
Published: Dec. 30, 2024
Alzheimer’s
disease
(AD)
poses
a
significant
worldwide
health
challenge,
requiring
novel
approaches
for
improved
models
and
treatment
development.
This
comprehensive
review
emphasises
the
systematic
development
improvement
of
biomimetic
brain
environment
to
address
shortcomings
existing
AD
enhance
efficiency
screening
potential
drug
treatments.
We
identify
drawbacks
in
traditional
emphasise
necessity
more
physiologically
accurate
systems
through
an
in-depth
analysis
current
literature.
aims
study
advanced
model
that
accurately
replicates
key
pathophysiological
aspects
using
cutting-edge
biomaterials
microenvironment
design.
Incorporating
biomolecular
elements
like
Tau
proteins
beta-amyloid
(Aβ)
plaques
improve
accuracy
illustrating
mechanisms.
The
expected
results
involve
creating
solid
foundation
high-throughput
with
enhanced
scalability,
translational
significance,
possibility
speeding
up
discovery.
Thus,
this
fills
gaps
modelling
shows
precise
efficient
treatments
AD.
Animals,
Journal Year:
2024,
Volume and Issue:
14(4), P. 541 - 541
Published: Feb. 6, 2024
The
aim
of
this
study
was
to
investigate
the
effects
dietary
chitosan
supplementation
on
muscle
composition,
digestion,
lipid
metabolism,
and
stress
resistance,
their
related
gene
expression,
juvenile
tilapia
(
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(7), P. 6346 - 6365
Published: June 25, 2024
Osteoporosis
represents
a
widespread
and
debilitating
chronic
bone
condition
that
is
increasingly
prevalent
globally.
Its
hallmark
features
include
reduced
density
heightened
fragility,
which
significantly
elevate
the
risk
of
fractures
due
to
decreased
presence
mature
osteoblasts.
The
limitations
current
pharmaceutical
therapies,
often
accompanied
by
severe
side
effects,
have
spurred
researchers
seek
alternative
strategies.
Adipose-derived
stem
cells
(ADSCs)
hold
considerable
promise
for
tissue
repair,
albeit
they
encounter
obstacles
such
as
replicative
senescence
in
laboratory
conditions.
In
comparison,
employing
ADSCs
within
three-dimensional
(3D)
environments
provides
an
innovative
solution,
replicating
natural
extracellular
matrix
environment
while
offering
controlled
cost-effective
vitro
platform.
Moreover,
utilization
photobiomodulation
(PBM)
has
emerged
method
enhance
ADSC
differentiation
proliferation
potential
instigating
cellular
stimulation
facilitating
beneficial
performance
modifications.
This
literature
review
critically
examines
shortcomings
osteoporosis
treatments
investigates
synergies
between
3D
cell
culture
PBM
augmenting
towards
osteogenic
lineages.
primary
objective
this
study
assess
efficacy
combined
enhancing
management.
research
notably
distinguished
its
thorough
scrutiny
existing
literature,
synthesis
recent
advancements,
identification
future
trajectories,
databases
PubMed,
Scopus,
Web
Science,
Google
Scholar
review.
Furthermore,
exploration
biomechanical
biophysical
stimuli
holds
refining
treatment
outlook
suggests
integrating
with
housed
advancing
regeneration
efforts.
Importantly,
aspires
catalyse
further
advancements
therapeutic
strategies
regeneration.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(3), P. 1145 - 1145
Published: Jan. 23, 2025
Guided
tissue
regeneration
(GTR)
membranes
are
pivotal
in
regenerative
medicine.
While
their
effectiveness
is
established
general
populations,
application
immunocompromised
patients,
such
as
those
with
diabetes
or
cancer,
remains
underexplored.
This
review
evaluated
evidence
on
GTR
settings,
focusing
mechanisms,
outcomes,
and
challenges
posed
by
systemic
conditions.
A
systematic
search
identified
studies
use
these
populations.
Inclusion
criteria
were
peer-reviewed
articles
English
human
samples
relevant
preclinical
models.
Of
218
articles,
5
met
the
criteria.
These
highlighted
advancements
technologies,
stem
cell
integration,
growth
factor-enriched
scaffolds,
scaffold-free
engineering.
Stem
cell-based
approaches
improved
regeneration,
especially
biomimetic
designs
incorporating
bone
morphogenetic
protein-2.
Innovations
like
microcavity-rich
scaffolds
enhanced
angiogenesis
osteogenesis,
while
constructs
minimized
immunogenicity
supported
functional
regeneration.
Preclinical
models
demonstrated
membranes’
potential
for
addressing
large-scale
deficits
compromised
environments.
show
promise
but
further
research
needed
to
validate
clinical
efficacy,
address
patient-specific
challenges,
evaluate
long-term
outcomes.
technologies
could
transform
medicine,
providing
sustainable
solutions
high-risk
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Stem
cells
possess
an
outstanding
ability
to
differentiate
into
various
cell
types,
making
them
instrumental
in
human
physiology
and
regenerative
medicine.
This
chapter
explores
the
fundamentals
of
stem
their
applications
complex
disorders
like
neurodegeneration
cardiovascular
disorders.
are
undifferentiated
capable
self-renewal
differentiation
specialised
including
neurons,
muscle
blood
cells.
They
further
categorised
embryonic
adult
Understanding
biology
is
crucial
for
harnessing
potential
treating
diabetes,
neurodegenerative
diseases,
autoimmune
conditions.
cell-based
therapy
offers
promising
avenues
reversing
damaged
tissues
organs,
as
well
providing
models
studying
disease
mechanisms
drug
discovery.
Recent
advancements
induced
pluripotent
(iPSCs)
have
enabled
generation
patient-specific
cells,
allowing
personalised
therapies
medicine
modelling.
However,
extreme
challenges
remain,
availability
donors,
characterisation
efficacy,
ethical
concerns,
tumourigenicity
immune
rejection.
In
summary,
hold
immense
promise
next-generation
by
offering
novel
therapeutic
strategies
albeit
investigation
essential
address
existing
realise
unprecedented
Jentashapir Journal of Cellular and Molecular Biology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 13, 2025
Context:
Recent
advances
in
induced
pluripotent
stem
cells
(iPSCs),
CRISPR-Cas9
gene
editing,
nanotechnologies,
and
artificial
intelligence
have
revolutionized
regenerative
medicine
(RM)
as
a
transformative
field
for
tackling
difficult
medical
problems.
These
breakthroughs
promise
specific
treatments,
proper
restoration
of
tissue
function,
substantial
improvements
the
quality
life
patients
whose
ailments
cannot
yet
be
cured.
This
review
explores
cutting-edge
advancements
RM
platforms
such
cell
therapy,
3D
bioprinting,
nanotechnology.
The
study
also
aims
to
shed
light
on
challenges
clinical
translation
policy
implications,
which
are
crucial
fostering
sustainable
progressive
discipline.
Evidence
Acquisition:
manuscript
draws
research
development
application
technologies.
It
synthesizes
data
cells,
engineering,
vitro
organoid
industry,
(AI),
nanotechnology
that
illustrate
therapeutic
potential.
identify
ethical,
regulatory,
practical
hurdles
translating
from
practice.
Results:
Breakthroughs
those
iPSC-derived
organoids,
nanostructured
materials
exhibit
significant
preclinical
settings.
Platforms
organ-on-chip
AI
tools
further
enhance
drug
discovery
treatment
monitoring,
while
biomaterials
scaffold-based
approaches
repair
regeneration.
Nevertheless,
despite
these
advances,
persist
regarding
scale-up,
safety,
ethical
considerations.
Conclusions:
Innovations
represent
paradigm
shift
purely
symptomatic
treatments
restorative
therapies.
Successful
integration
into
practice
will
require
multidisciplinary
collaborative
work,
imposition
rigorous
safety
protocols,
enabling
regulatory
frameworks.
Addressing
would
enable
realize
its
true
potential
foundation
21st-century
healthcare.
Receptors,
Journal Year:
2025,
Volume and Issue:
4(2), P. 9 - 9
Published: April 2, 2025
Bioelectric
membrane
potentials
regulate
cellular
growth,
differentiation,
and
movement.
Disruptions
in
bioelectric
signaling
are
strongly
linked
to
cancer
development,
as
abnormal
ion
channel
activity
can
drive
tumor
progression.
In
breast
cancer,
dysfunction
neuroreceptor-related
pathways
play
significant
roles
the
cell
cycle,
epithelial–mesenchymal
transition,
angiogenesis,
inflammation,
microenvironment,
Neuroreceptors
critical
not
only
initiating
advancing
but
also
conferring
resistance
treatments.
a
key
role,
with
dopamine
receptor
D2
activation
reducing
growth
by
40%
preclinical
models,
while
serotonin
has
been
shown
promote
transition
(EMT),
increasing
invasiveness.
Advances
understanding
these
biological
mechanisms
could
lead
more
cost-effective
less
invasive
therapeutic
strategies
treat
tumors.
This
review
explores
expanding
evidence
connecting
focusing
on
neuroreceptor
pharmacology
transformative
approach.
Examining
modulation
of
bioelectricity
through
influence
progression
integrating
insights
into
development
offers
promising
path
for
addressing
treatment
challenges
improving
precision
managing
aggressive
subtypes.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 6, 2025
Neurodegenerative
diseases
including
Alzheimer's
and
Parkinson's
disease
are
age-related
disorders
which
severely
impact
quality
of
life
impose
significant
societal
burdens.
Cellular
senescence
is
a
critical
factor
in
these
disorders,
contributing
to
their
onset
progression
by
promoting
permanent
cell
cycle
arrest
reducing
cellular
function,
affecting
various
types
cells
brain.
Recent
advancements
regenerative
medicine
have
highlighted
"R3"
strategies-rejuvenation,
regeneration,
replacement-as
promising
therapeutic
approaches
for
neurodegeneration.
This
review
aims
critically
analyze
the
role
neurodegenerative
organizes
within
R3
paradigm.
Specifically,
we
examine
stem
therapy,
direct
lineage
reprogramming,
partial
reprogramming
context
R3,
emphasizing
how
interventions
mitigate
counteracting
aging-related
Ultimately,
this
seeks
provide
insights
into
complex
interplay
between
neurodegeneration
while
highlighting
promise
cell-based
strategies
address
debilitating
conditions.
