International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12784 - 12784
Published: Nov. 28, 2024
Resolvins
are
specialized
pro-resolving
mediators
(SPMs)
derived
from
omega-3
fatty
acids
that
play
a
critical
role
in
resolving
inflammation
and
restoring
tissues
to
state
of
health
after
an
immune
response.
Their
chronic
inflammatory
conditions
highlights
their
importance
maintaining
balance
between
effective
response
the
resolution
prevent
tissue
damage.
Periodontal
disease
is
condition
affecting
surrounding
teeth,
leading
gum
damage
bone
loss.
Chronic
periodontal
can
exacerbate
systemic
influence
other
conditions,
such
as
diabetes.
There
bidirectional
relationship
diabetes
disease,
both
characterized
by
oral
complications.
This
narrative
review
aims
synthesize
current
knowledge
on
how
resolvins
pathways
repair
mechanism
patients
with
type
2
Furthermore,
this
serves
foundation
for
developing
targeted
therapeutic
strategies,
addressing
pressing
need
treatments
consider
outcomes.
Frontiers in Oral Health,
Journal Year:
2025,
Volume and Issue:
6
Published: Jan. 17, 2025
Periodontal
disease
is
a
widespread
chronic
inflammatory
state
influencing
the
supporting
anatomy
of
teeth,
distinguished
by
oxidative
stress,
progressive
bone
loss,
and
tissue
damage.
Recent
articles
have
highlighted
significance
mitochondrial
dynamics,
mainly
Mitofusin-1
(MFN1)
along
with
Mitofusin-2
(MFN2),
inflammation
regulation,
homeostasis,
in
cellular
function.
The
aim
current
study
to
comprehensively
review
including
evaluate
roles
MFN2
MFN1
pathogenesis
as
well
progression
periodontal
disease,
foregrounding
their
effect
on
integrity,
pathways,
stress.
Studies
were
selected
depending
inclusion
criteria
based
health.
Data
from
chosen
vivo,
clinical
studies,
vitro
synthesized.
Outcomes
indicate
that
are
important
for
preserving
function,
mitigating
damage,
fusion.
Decreased
levels
these
proteins
related
elevated
inflammation,
increased
dysfunction
tissues.
comprehensive
shows
cell
survival,
dynamics
within
disease.
prospective
targeting
therapeutic
policy
promising,
presenting
avenues
upgraded
management
regeneration.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 115 - 126
Published: Jan. 1, 2025
Abstract:
Diabetic
periodontitis
is
a
common
oral
complication
of
diabetes
characterized
by
progressive
destruction
periodontal
tissues.
Recent
evidence
suggests
that
mitochondrial
dysfunction
plays
crucial
role
in
the
pathogenesis
and
progression
this
condition.
This
review
aims
to
systematically
summarize
potential
mechanisms
diabetic
periodontitis.
We
first
explore
relationship
between
dysfunction,
then
analyze
specific
manifestations
periodontitis,
including
morphological
changes,
energy
metabolism
disorders,
increased
oxidative
stress,
enhanced
apoptosis.
further
delve
into
connections
pathogenic
such
as
exacerbated
inflammatory
responses,
decreased
tissue
repair
capacity,
autophagy
dysregulation.
Finally,
we
discuss
therapeutic
targets
based
on
function,
antioxidant
strategies,
mitochondria-targeted
drugs,
regulators.
also
propose
future
research
directions,
emphasizing
need
for
in-depth
exploration
molecular
mechanisms,
development
new
diagnostic
markers
personalized
treatment
approaches.
provides
insights
understanding
offers
theoretical
basis
developing
targeted
prevention
strategies
improve
health
patients.
Keywords:
inflammation,
Oral Diseases,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Periodontal
disease
is
a
common
chronic
inflammatory
condition
affecting
the
tissues
that
support
teeth,
leading
to
their
destruction.
Mitophagy,
specialized
form
of
autophagy
responsible
for
degrading
damaged
mitochondria,
plays
crucial
role
in
maintaining
cellular
homeostasis.
However,
its
periodontal
progression
remains
poorly
understood.
This
review
aims
summarize
recent
research
on
mitophagy's
pathogenesis.
A
comprehensive
literature
mitophagy
was
conducted
using
PubMed,
Scopus,
and
Web
Science
databases,
employing
keywords
related
such
as
"periodontal,"
"periodontitis,"
"gingiva,"
"gingivitis."
18
original
studies
revealed
by
regulating
key
pathophysiological
mechanisms.
Specifically,
modulates
inflammation
influencing
pro-inflammatory
cytokines
mitochondrial
reactive
oxygen
species.
Additionally,
it
essential
alveolar
bone
remodeling,
impacting
both
resorption
regeneration.
Mitophagy
also
regulates
cell
apoptosis
within
tissues,
helping
preserve
function
tissue
integrity
during
progression.
pathogenesis
modulating
inflammation,
death
tissues.
Further
needed
explore
therapeutic
potential
treatment
improve
targeted
interventions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9806 - 9806
Published: Sept. 11, 2024
Given
the
posited
role
of
oxidative
stress
in
pathogenesis
both
periodontitis
and
type
2
diabetes
mellitus
(T2DM),
it
may
also
serve
as
a
link
between
these
highly
prevalent
chronic
inflammatory
diseases.
This
view
is
supported
by
an
ample
body
evidence
indicating
that
severity
progression
part
driven
diabetes,
while
periodontal
infection
hinder
attainment
adequate
glycemic
control
diabetic
patients.
Thus,
this
review
focuses
on
potential
synergistic
interactions
along
stress–inflammation
pathway
characterizing
conditions.
Because
T2DM
share
same
risk
factors
compromise
patients’
quality
life,
to
develop
effective
strategies
for
combatting
conditions,
their
mutual
influence
needs
be
explored.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1998 - 1998
Published: Feb. 25, 2025
Periodontal
disease,
a
prevalent
oral
inflammatory
condition,
is
implicated
in
exacerbating
systemic
diseases.
However,
the
molecular
mechanisms
underlying
this
association
remain
unclear.
In
study,
we
performed
RNA
sequencing
of
gingival
tissue
samples
collected
from
mouse
model
periodontal
disease
at
multiple
time
points
to
investigate
dynamic
transcriptomic
changes
during
progression.
Our
analysis
revealed
distinct
temporal
gene
expression
patterns
associated
with
key
and
immune
response
pathways.
These
findings
suggest
stepwise
progression
process,
potentially
contributing
inflammation
through
shared
signaling
networks.
We
further
identified
specific
genes
pathways
that
may
mediate
bidirectional
relationship
between
conditions
such
as
cardiovascular
diabetes.
By
elucidating
dynamics
study
provides
insights
into
pathogenesis
its
implications.
It
identifies
potential
biomarkers
therapeutic
targets
for
local
management.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 12, 2025
Periodontitis
is
the
leading
cause
of
tooth
loss
in
adults
due
to
progressive
bone
destruction,
which
closely
related
dysfunction
mesenchymal
stem
cells
(BMSCs).
Existing
evidence
suggests
that
mitochondrial
disorders
are
associated
with
periodontitis.
However,
whether
dysregulation
contributes
osteogenic
impairment
BMSCs
and
underlying
mechanisms
remain
unclear.
Macrophages
have
been
shown
communicate
extensively
Recent
studies
reported
a
novel
manner
cellular
communication
mitochondria-rich
extracellular
vesicles(MEVs)
transfer
mitochondria
from
parent
recipient
cells,
playing
role
both
physiological
pathological
conditions.
Therefore,
we
aimed
investigate
MEVs
orchestrating
crosstalk
between
macrophages
periodontitis
formulate
management
strategies
for
loss.
Our
results
revealed
underwent
significant
inflammation
derived
these
played
alveolar
destruction.
Furthermore,
cell
imaging
showed
inflammatory
packaged
numerous
damaged
into
MEVs,
entry
impaired
disrupted
dynamics
hindered
donut-shaped
formation,
dysfunction.
Proteomic
analysis
proteins
enriched
macrophage-derived
were
largely
formation
transport
vesicles.
Additionally,
found
significantly
increased
lipocalin
2
(LCN2)
LCN2
perturbed
morphological
changes
by
inducing
degradation
OMA1
accumulation
OPA1,
resulting
osteogenesis
BMSCs.
Inhibition
rescued
The
via
exacerbates
resorption
through
LCN2/OMA1/OPA1
signaling
alleviates
loss,
suggesting
promising
therapeutic
strategy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3225 - 3225
Published: March 30, 2025
Although
periodontal
disease
(PD)
is
reported
to
be
associated
with
changes
in
various
genes
and
proteins
both
invading
bacteria
the
host,
its
molecular
mechanism
of
pathogenesis
remains
unclear.
Changes
immune
inflammatory
play
a
significant
role
PD
pathogenesis.
Some
reports
relate
alterations
cellular
epigenetic
patterns
characteristics,
while
several
high-throughput
analyses
indicate
thousands
differentially
methylated
patients
controls.
Furthermore,
DNA
methylation
inflammation-related
have
been
linked
efficacy
therapy,
as
demonstrated
by
findings
related
cytochrome
C
oxidase
II
gene.
Distinct
mesenchymal
stem
cells
from
controls
persisted
despite
reversal
phenotypic
PD.
Methyl
groups
for
are
supplied
S-adenosylmethionine,
which
synthesized
involvement
folate,
an
essential
nutrient
known
maintaining
mitochondrial
homeostasis,
compromised
Folate
may
benefit
through
antioxidant
action
against
reactive
oxygen
nitrogen
species
that
overproduced
dysfunctional
mitochondria.
As
such,
methylation,
dietary
quality
control
interact
In
this
narrative/hypothesis
review,
we
demonstrate
how
may,
turn,
improved
potentially
altering
nucleus
Therefore,
folate-based
intervention
recommended
prevention
adjunct
therapy.
At
same
time,
further
research
needed
on
mechanisms
beneficial
effects
folate
studies.
BMC Oral Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 10, 2025
The
current
study
aimed
to
assess
the
impact
of
periodontitis
on
oxidative
stress
parameters
by
examining
serum
total
antioxidant
capacity
(TAS),
oxidant
status
(TOS),
index
(OSI),
thiol/
disulfide
homeostasis
and
ischemia
modified
albumin
(IMA).
had
90
participants,
categorized
into
3
groups:
Group
1:
Periodontally
healthy;
2:
Stage
II
Grade
B
periodontitis;
3:
III
IV
periodontitis.
Demographic
periodontal
variables
were
assessed.
levels
TAS,
TOS,
OSI,
IMA,
thiol/disulfide
No
significant
differences
in
sex
age
detected
among
groups
(p
>
0.05).
When
compared
1,
all
clinical
measurements
statistically
significantly
greater
<
Statistical
analysis
revealed
no
OSI
highest
IMA
value
was
observed
=
0.037),
whereas
native
thiol
0.00),
0.00)
values
0.023)
1.
These
findings
indicate
that
could
hold
promise
as
a
potential
biomarker
inflammation
