Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
Journal of Hematology & Oncology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Language: Английский
A Review on Multicellular Spheroids and Organoids for Breast Cancer Diagnosis and Therapy
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 20, 2024
In
response
to
escalating
ethical
and
regulatory
concerns
surrounding
animal
testing
in
drug
development,
bodies
such
as
the
Food
Drug
Administration
(FDA)
have
implemented
updated
guidelines
encourage
exploration
of
alternative
methodologies.
Simultaneously,
European
regulations
instituted
stringent
restrictions
on
for
assessment.
Consequently,
researchers
increasingly
turned
innovative
approaches
like
Three-dimensional
spheroid
cultures
organoids
address
these
challenges.
These
advanced
models
offer
promising
avenues
investigating
breast
cancer
efficacy,
they
accurately
mimic
intricate
architecture
cellular
diversity
human
tumors.
This
strategic
pivot
toward
methodologies
reflects
a
collective
commitment
advancing
research
while
ensuring
compliance
with
evolving
standards,
thereby
fostering
development
more
precise
personalized
therapeutic
strategies.
Language: Английский
Exploring Drug Repurposing for Interstitial Cystitis/Bladder Pain Syndrome: Defining Novel Therapeutic Targets
Neurourology and Urodynamics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Interstitial
cystitis/bladder
pain
syndrome
(IC/BPS)
is
a
debilitating
condition
of
unknown
etiology.
Effective
therapies
for
this
could
not
have
been
developed
in
the
last
century.
Drug
repurposing
practical
strategy
enhancing
patient
access
to
successful
therapies.
It
an
approach
discovering
novel
applications
licensed
or
investigational
pharmaceuticals
that
extend
beyond
initial
medical
indication.
This
work
aims
identify
repurposable
medications
through
bioinformatics
discover
potential
drugs
compounds
can
reverse
IC/BPS
disease
signature.
Language: Английский