The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(10)

Published: Sept. 24, 2024

Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body liver. Carvacrol natural phytocompound that stands out with antioxidant, anti-inflammatory, antiapoptotic properties. The current study aims to investigate protective feature carvacrol against sodium arsenite-induced liver toxicity. Thirty-five Sprague-Dawley male rats were divided into five groups: Control, Sodium arsenite (SA), CRV, SA + CRV25, CRV50. was administered via oral gavage at dose 10 mg/kg for 14 days, 30 min later, CRV 25 or 50 gavage. Oxidative stress, inflammation, apoptosis, autophagy damage pathways parameters, tissue integrity analyzed using biochemical, molecular, western blot, histological, immunohistological methods. decreased oxidative stress by suppressing malondialdehyde levels increasing superoxide dismutase, catalase, glutathione peroxidase activities, levels. reduced inflammation reducing increased NF-κB cytokines (TNF-α, IL-1β, IL-6, RAGE, NLRP3) it stimulates. also autophagic (Beclin-1, LC3A, LC3B) apoptotic (P53, Apaf-1, Casp-3, Casp-6, Casp-9, Bax) parameters. preserved impaired structure. alleviated increases parameters rat tissues. beneficial preserving integrity.

Language: Английский

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Advances in postharvest nanotechnology: Enhancing fresh produce shelf life and quality to reduce losses and waste

Postharvest Biology and Technology, Journal Year: 2025, Volume and Issue: 222, P. 113397 - 113397

Published: Jan. 20, 2025

Language: Английский

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Synthesis of L-carvone-derived imidazo[1,2-a]pyrimidine / nano sodium alginate complexes with significant antifungal activity and sustained releasing performance

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141823 - 141823

Published: Feb. 1, 2025

Language: Английский

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Nanoencapsulated carvacrol: a new fungicide for grapes that has no impact on the fermentation and remains undetectable in the wine aroma

European Food Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

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RSM and ANN modeling-based optimization approach for the development of alginate-chitosan particles containing Rosmarinus officinalis essential oil

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

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Preparation and characterization of carvacrol/soybean protein isolate composite film with efficient antimicrobial and antioxidant activities and its application in grape preservation

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141572 - 141572

Published: Oct. 10, 2024

Language: Английский

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Carvacrol as a food additive: Toxicological aspects and the role of nanotechnology in enhancing its antimicrobial and antioxidant properties

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115256 - 115256

Published: Oct. 22, 2024

Language: Английский

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Nanoencapsulation reduces the perception of carvacrol odor, enhances the control of Botrytis cinerea growth and preserves grape quality

Food Research International, Journal Year: 2024, Volume and Issue: 201, P. 115589 - 115589

Published: Dec. 30, 2024

Language: Английский

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Tailoring hydrophobicity and strength in spider silk-inspired coatings via thermal treatments

Computational and Structural Biotechnology Journal, Journal Year: 2024, Volume and Issue: 25, P. 177 - 185

Published: Sept. 17, 2024

Language: Английский

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Tailoring hydrophobicity and strength in spider silk-inspired coatings via thermal treatments

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 15, 2024

Abstract The advent of advanced coatings has transformed material functionalities, extending their roles from basic coverage and visual appeal to include unique properties such as self-healing, superior hydrophobicity, antimicrobial action. However, the traditional dependency on petrochemical-derived materials for these raises environmental concerns. This study proposes use renewable alternative coating development. We present bioengineered spider silk-inspired protein (SSIP), produced through recombinant technology, a viable, eco-friendly due ease processing under ambient pressure utilization water solvent, alongside exceptional physicochemical properties. Our research investigates effects different thermal treatments concentrations mechanical strength surface repellency silica bases. findings reveal direct correlation between temperature heat treatment enhancements in hydrophobicity strength, where elevated temperatures facilitate increased resistance improved integrity. Consequently, we advocate SSIPs promising, sustainable choice coatings, providing pathway fine-tune recipes better hydrophobic with reduced ecological footprint, finding potential uses various fields electronics.

Language: Английский

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