P4HA1: an important target for treating fibrosis related diseases and cancer DOI Creative Commons
Xuewen Yang, Dong Zhang, Mengmeng Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 6, 2024

Fibrosis is significantly associated with a wide variety of diseases and involved in their progression. activated under the influence different combinations factors considered double-edged sword. Although there has been much research on organ fibrosis recent years, cancers are not well controlled terms prevention, treatment, prognosis. Clinical studies still lack exploration discovery effective targets for pathogenesis fibrosis. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) protein kinase synthesis secretion collagen related to sustained activation P4HA1. As further being conducted, potential role P4HA1 development fibrosis-associated cancer becoming clear. Consequently, we conducted systematic review discussion various fibrosis-related cancers. We reviewed possible strategies diagnosis treatment cancers, analyzed its relevance as biomarker cancer.

Language: Английский

Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment DOI Creative Commons

Yunheng Liu,

Lei Si, Yuxuan Jiang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

Citations

2
Cancer and the Microbiome of the Human Body DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, María López-Garzón

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2790 - 2790

Published: Aug. 21, 2024

Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.

Language: Английский

Citations

4
Tumor-associated stroma shapes the spatial tumor immune microenvironment of primary Ewing sarcomas DOI Creative Commons
Christopher Kuo, Krinio Giannikou,

N.-K. Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract To date, few studies have detailed the tumor microenvironment (TME) of Ewing sarcoma (EwS). The TME has a vital role in cancer survival and progression with implications drug resistance immune escape. By performing spatially resolved transcriptomic analysis primary treatment-naïve EwS samples, we discovered greater stromal enrichment localized tumors compared to metastatic tumors. Through spatial ligand-receptor analysis, show that enriched regions harbor unique extracellular matrix related cytokines, recruitment proinflammatory microenvironmental signals, implying stroma may play an anti-tumorigenic by acting as center. All expressed pro-tumorigenic MIF-CD74 signaling, suggesting potential immune-evasive mechanism immunotherapy target. Our findings provide insight into cell/stromal cell interactions serve valuable resource for further investigations EwS.

Language: Английский

Citations

0
Exosomes in Precision Oncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics DOI Open Access

Emile M. Youssef,

Dannelle Palmer,

Brandon Fletcher

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 940 - 940

Published: March 10, 2025

Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.

Language: Английский

Citations

0
Unveiling the microbial influence: bacteria’s dual role in tumor metastasis DOI Creative Commons

Li-Ying Lin,

Dongyan Zhang

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

As cancer research advances, the intricate relationship between microbiome and is gaining heightened recognition, especially concerning tumor metastasis, where bacterial involvement becomes increasingly complex. This review seeks to systematically examine dual roles of bacteria in metastasis process, encompassing both mechanisms that facilitate inhibitory effects exerted by specific microorganisms. We explore through which influence cell migration inducing chronic inflammation, evading host immune responses, remodeling ECM. Moreover, immunomodulatory potential probiotics genetically engineered offers promising prospects for prevention treatment metastasis. article elucidates complexity emerging frontiers examining clinical significance as biomarkers evaluating antibiotic usage on metastatic process. posit comprehending biological characteristics bacteria, a critical component microenvironment, will offer innovative strategies theoretical foundations treatment. Furthermore, this explores future directions, including application technologies bacteria-based therapeutic strategies, thereby offering valuable perspective development novel anti-cancer approaches.

Language: Английский

Citations

0
A Breast Cancer Prognostic Model Based on Folic Acid Metabolism-Related Genes to Reveal the Immune Landscape DOI
Lin Lv, Xiaotao Zhu, Cong Jin

et al.

Hormone and Metabolic Research, Journal Year: 2025, Volume and Issue: 57(04), P. 262 - 272

Published: April 1, 2025

Abstract Breast cancer (BC) threatens women’s health, and the prognosis is dismal. Folic acid metabolism affects prognosis, but research on folic metabolism-related genes (FMRs) in BC scarce. We used TCGA-BRCA as training set GSE21653 validation set. Five FMRs (PLAT, SERPINA3, IFNG, SLC19A1, NFKB2) were screened via univariate LASSO Cox regression analyses, a prognostic model was built based multivariate analysis. The showed excellent predictive performance. Differentially expressed high- low-risk groups enriched steroid hormone biosynthesis neuroactive ligand-receptor interaction pathways. group exhibited higher immune cell infiltration better immunotherapy response. AM-5992 5-fluorodeoxyuridine 10mer may be potential drugs. This FMR-based can accurately predict offering clinical reference.

Language: Английский

Citations

0
The Role of the Microbiome and of Radiotherapy-Derived Metabolites in Breast Cancer DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, Rafael Cardoso Maciel Costa Silva

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3671 - 3671

Published: Oct. 30, 2024

The gut microbiome has emerged as a crucial player in modulating cancer therapies, including radiotherapy. In the case of breast cancer, interplay between and radiotherapy-derived metabolites may enhance therapeutic outcomes minimize adverse effects. this review, we explore bidirectional relationship cancer. We explain how composition influences progression treatment response, its treatments influence composition. A dual role for is explored article, highlighting both their benefits potential hazards. By integrating genomics, metabolomics, bioinformatics tools, present comprehensive overview these interactions. study provides real-world insight through studies clinical trials, while innovations such probiotics, dietary interventions are examined to modulate effectiveness. Moreover, ethical considerations patient perspectives discussed, ensuring understanding subject. Towards revolutionizing strategies improving outcomes, review concludes with future research directions. It also envisions metabolite into personalized therapy.

Language: Английский

Citations

3
Microbiome and bladder cancer: the role of probiotics in treatment DOI

Leila Dadgar-Zankbar,

Maryam Mokhtaryan,

Elnaz Bafandeh

et al.

Future Microbiology, Journal Year: 2024, Volume and Issue: 20(1), P. 73 - 90

Published: Oct. 24, 2024

Bladder cancer (BCa) remains a significant global health challenge, with increasing interest in the role of bladder microbiome its pathogenesis, progression and treatment outcomes. The complex relationship between microbiome, as well potential impact probiotics on effectiveness, is currently under investigation. Research suggests that microbiota may influence BCa recurrence prevention enhance efficacy Bacillus Calmette-Guérin (BCG) vaccine. Recent studies reveal differences individuals without those disease. In healthy bladder,

Language: Английский

Citations

2
P4HA1: an important target for treating fibrosis related diseases and cancer DOI Creative Commons
Xuewen Yang, Dong Zhang, Mengmeng Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 6, 2024

Fibrosis is significantly associated with a wide variety of diseases and involved in their progression. activated under the influence different combinations factors considered double-edged sword. Although there has been much research on organ fibrosis recent years, cancers are not well controlled terms prevention, treatment, prognosis. Clinical studies still lack exploration discovery effective targets for pathogenesis fibrosis. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) protein kinase synthesis secretion collagen related to sustained activation P4HA1. As further being conducted, potential role P4HA1 development fibrosis-associated cancer becoming clear. Consequently, we conducted systematic review discussion various fibrosis-related cancers. We reviewed possible strategies diagnosis treatment cancers, analyzed its relevance as biomarker cancer.

Language: Английский

Citations

0