Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: unknown, P. 111878 - 111878
Published: Oct. 1, 2024
Language: Английский
Life Sciences, Journal Year: 2025, Volume and Issue: 363, P. 123415 - 123415
Published: Jan. 25, 2025
Language: Английский
Citations
1
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: April 17, 2025
Diabetic cardiomyopathy has a very high incidence and serious clinical consequences, making it an urgent problem to be solved. Angiogenesis is significant phenotype in the occurrence development of diabetic cardiomyopathy, especially damage angiogenesis cardiac microvessels, which inextricably linked risk patients. In current basic research, there still lack treatment methods that directly target cardiomyopathy. This study hopes discover key molecules related damage, provide ideas for possible interventions. Sequencing data animals cells were obtained from GEO database, differentially expressed genes analyzed. Subsequently, angiogenesis-related clustered functional pathway analysis. Then, microangiogenesis mice changes glucose-stimulated HUVECs verified, top three verified using western blot. 24 associated with found GSE241565(human) GSE215979(mice). Among them, 11 showed same trend two databases. Then CD31 staining hearts microvascular was impaired, decreased tube formation, wound healing migration weakened. Finally, 3 most no difference between Edn1 Lepr. At time, Efnb2 significantly increased under glucose stimulation. Combined sequencing animal cell models differential screened. These findings not only elucidate novel molecular axis linking but also highlight as potential therapeutic target.
Language: Английский
Citations
1
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 13, 2024
Abstract Coronary artery disease has a high mortality rate and is striking public health concern, affecting substantial portion of the global population. On early onset myocardial ischemia, thrombolytic therapy coronary revascularization could promptly restore bloodstream nutrient supply to ischemic tissue, efficiently preserving less severely injured myocardium. However, abrupt re-establishment blood flow triggers significant discharge previously accumulated oxidative substances inflammatory cytokines, leading further harm referred as ischemia/reperfusion (I/R) injury. Diabetes significantly raises vulnerability heart I/R injury due disrupted glucose lipid processing, impaired insulin sensitivity metabolic signaling, increased responses. Numerous studies have indicated that adipokines are crucial in etiology pathogenesis obesity, diabetes, hyperlipidemia, hypertension, disease. Adipokines such adiponectin, adipsin, visfatin, chemerin, omentin, apelin, which possess protective properties against activity resistance, been shown confer protection conditions atherosclerosis, hypertrophy, injury, diabetic complications. other hand, leptin resistin, known for their pro-inflammatory characteristics, linked elevated cardiac deposition, fibrosis. Meteorin-like (metrnl) exhibits opposite effects various pathological conditions. data on I/R, especially still incomplete controversial. This review focuses recent research regarding categorization function muscle, identification different signaling pathways involved under conditions, aiming facilitate exploration therapeutic strategies diabetes.
Language: Английский
Citations
4
Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 39(9), P. 1957 - 1959
Published: May 9, 2024
Language: Английский
Citations
2
Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: unknown, P. 111878 - 111878
Published: Oct. 1, 2024
Language: Английский
Citations
1