Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 30, 2024
Language: Английский
Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)
Published: Jan. 12, 2025
Abstract Preserving the balance of metabolic processes in endothelial cells (ECs) and vascular smooth muscle (VSMCs), is crucial for optimal function integrity. ECs are metabolically active depend on aerobic glycolysis to efficiently produce energy their essential functions, which include regulating tone. Impaired EC metabolism linked damage, increased permeability inflammation. Metabolic alterations VSMCs also contribute dysfunction atherosclerosis hypertension. Magnesium (Mg 2+ ) second most abundant intracellular divalent cation influences molecular that regulate function, including vasodilation, vasoconstriction, release vasoactive substances. Mg critically involved maintaining cellular homeostasis since it an cofactor ATP, nucleic acids hundreds enzymes processes. Low levels have been dysfunction, tone, inflammation arterial remodeling. Growing evidence indicates important role transient receptor potential melastatin‐subfamily member 7 (TRPM7) channel regulation VSMCs. In vasculature, TRPM7 deficiency leads impaired contraction, phenotypic switching VSMCs, fibrosis, characterize phenotype Here we provide a comprehensive overview TRPM7/Mg how VSMC such as glucose homeostasis, redox regulation, phosphoinositide signaling, mineral metabolism. The putative altered hypertension discussed.
Language: Английский
Citations
3
Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Citations
2
Clinics and Practice, Journal Year: 2024, Volume and Issue: 14(2), P. 521 - 535
Published: March 22, 2024
The importance of maintaining proper magnesium intake and total body content in preserving human health remains underappreciated among medical professionals laymen. This review aimed to show the hypomagnesemia as a modifiable risk factor for developing disease processes. We searched PubMed database Google Scholar using keywords ‘magnesium’, ‘diabetes’, ‘cardiovascular disease’, ‘respiratory ‘immune system’, ‘inflammation’, ‘autoimmune ‘neurology’, ‘psychiatry’, ‘cognitive function’, ‘cancer’, ‘vascular calcification’. In multiple contexts search terms, all reviews, animal experiments, observational data indicated that deficiency can lead or contribute many states. conclusions several in-depth reviews support our working hypothesis its supplementation are often undervalued underutilized. Although much research has confirmed supply tissue levels, simple inexpensive not yet been sufficiently recognized promoted.
Language: Английский
Citations
9
Clinical Kidney Journal, Journal Year: 2025, Volume and Issue: 18(Supplement_1), P. i27 - i45
Published: March 1, 2025
ABSTRACT Valvular calcification, developing either in the mitral or aortic valve, is highly prevalent patients suffering from chronic kidney disease (CKD), whom their presence correlates with higher cardiovascular and all-cause mortality risk. To date, exact mechanisms that promote heart valve calcification remain unclear, none of treatments tested so far have shown efficacy preventing valvular fibrocalcific remodelling. It therefore essential to improve our understanding involved pathological process if we are find new, effective therapies. The purpose this review (i) summarize current knowledge by which CKD related therapies affect cell activity, (ii) present latest therapeutic targets identified preclinical studies, (iii) discuss most recent clinical trials evaluating aimed at CKD.
Language: Английский
Citations
1
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: July 12, 2024
Cardiovascular diseases (CVDs) account for nearly half of chronic kidney disease (CKD)-related deaths. Hypomagnesemia has been associated with various cardiovascular conditions and predicts a decline in renal function leading to end-stage (ESRD). The objective this review is delve into discuss the significance magnesium (Mg) functions, clinical consequences hypomagnesemia on CVD CKD, benefits Mg supplementation managing CKD. This result an extensive search pertinent articles databases like PubMed, Medline, PubMed Central, Google Scholar. Based literature conducted review, we concluded that protects against CVDs delays progression can regulate pathways inflammation, oxidative stress, fibrosis. Therefore, maintaining slightly elevated levels timely may benefit patients There need additional prospective randomized controlled trials fully comprehend therapeutic effects CKD along setting individualized target serum such patients.
Language: Английский
Citations
4
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101599 - 101599
Published: Feb. 19, 2025
Language: Английский
Citations
0
Journal of Cutaneous Medicine and Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Calcinosis cutis, characterized by the pathological deposition of insoluble calcium salts in skin, is associated with several disease entities, particularly autoimmune conditions such as scleroderma and dermatomyositis. Lesions calcinosis are often painful, prone to ulceration, significantly impair quality life. Despite clinical impact, no effective treatments have been established date, making prevention this condition a critical priority. In narrative review, we explore evidence suggesting that supplementation may contribute skin calcification. Calcium supplements demonstrated transiently elevate plasma levels, potentially promoting dystrophic tissue calcification—a process be exacerbated context magnesium vitamin K2 deficiencies. Furthermore, has an increased risk adverse cardiovascular events; concern relevant patients diseases who already face elevated comorbidity. Notably, there robust supporting efficacy preventing osteoporosis. Instead, sufficient dietary intake protein, along micronutrients for homeostasis (magnesium, zinc, D 3 , K 2 ), should considered alternatives supplementation.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1655 - 1655
Published: May 13, 2025
Vitamin D and magnesium are essential nutrients that play key roles in an athlete’s performance, recovery, overall health. is crucial for bone health (aiding calcium absorption preventing stress fractures), muscle function (preventing weakness injury), reducing respiratory infections. Magnesium fundamental function, adenosine triphosphate production contraction, electrolyte balance, strength, cardiovascular The requirement of healthy adults estimated at 300–400 mg/day, but there evidence athletes may have higher needs compared to sedentary persons. vitamin closely linked—vitamin aids absorption, while vital synthesis, transport, activation. Given their importance athletes, this article explores functions, interactions, the effects deficiencies supplementation athletic populations.
Language: Английский
Citations
0
Pediatric Nephrology, Journal Year: 2025, Volume and Issue: unknown
Published: May 17, 2025
Children and young people with chronic kidney disease (CKD) are at risk for deficiency or excess of magnesium trace elements. Kidney function, dialysis, medication, dietary supplemental intake can affect their biochemical status. There is much uncertainty about the requirements elements in CKD, which leads to variation practice. The Pediatric Renal Nutrition Taskforce an international team pediatric dietitians nephrologists, formed develop evidence-based clinical practice points improve nutritional care children CKD. PICO (patient, intervention, comparator, outcomes) questions led literature searches, were conducted ascertain current status, intake, factors leading differing from healthy peers, guide CKD stages 2-5, on post-transplantation. We address assessment intervention chromium, copper, fluoride, iodine, manganese, selenium, zinc. suggest routine magnesium. Trace element based suspicion factors, including accumulation, losses, medications, nutrient interactions, comorbidities. In particular, we assessing magnesium, zinc when growth poor, evaluating presence proteinuria. A structured approach management, biochemical, physical, assessment, beneficial paucity evidence. Research recommendations suggested.
Language: Английский
Citations
0
Sclerosis, Journal Year: 2024, Volume and Issue: 2(3), P. 217 - 265
Published: Aug. 26, 2024
Apart from the significant progress scientific community has made during last few decades, inflammation-mediated kidney-related diseases like chronic and diabetic kidney (CKD DKD) glomerulosclerosis still continue to raise mortality rates. Recently, conventional therapeutic interventions have been put aside, since natural vitamin D-derived treatment gained attention offered several promising outcomes. Within this article, utilization of D its analogues as potential toward diseases, due their anti-inflammatory, antioxidant anti-fibrotic activity, is outlined. Vitamin including calcitriol, paricalcitol 22-oxacalcitriol previously explored for such applications, but hidden yet be further elucidated. Several clinical trials demonstrated that analogues’ supplementation correlated with inflammatory signaling oxidative stress regulation, immunity/metabolism augmentation subsequently, healthcare-related infections’ prevention, results these are thoroughly evaluated. The highlighted research outcomes urge study on a plethora view fully clarify substantial anti-inflammatory constituents renal diseases-related health-promoting properties in many kidney-associated healthcare complications infections.
Language: Английский
Citations
2