Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes DOI Open Access
Jarosław Nuszkiewicz,

Beata Kukulska-Pawluczuk,

Katarzyna Piec

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4258 - 4258

Published: July 21, 2024

Acute ischemic stroke (AIS) remains a major cause of mortality and long-term disability worldwide, driven by complex multifaceted etiological factors. Metabolic dysregulation, gastrointestinal microbiome alterations, systemic inflammation are emerging as significant contributors to AIS pathogenesis. This review addresses the critical need understand how these factors interact influence risk outcomes. We aim elucidate roles dysregulated adipokines in obesity, impact gut microbiota disruptions, neuroinflammatory cascade initiated lipopolysaccharides (LPS) AIS. Dysregulated obesity exacerbate inflammatory responses, increasing severity. Disruptions subsequent LPS-induced neuroinflammation further link Advances neuroimaging biomarker development have improved diagnostic precision. Here, we highlight for approach management, integrating metabolic, microbiota, insights. Potential therapeutic strategies targeting pathways could significantly improve prevention treatment. Future research should focus on elucidating developing targeted interventions mitigate impacts metabolic imbalances,

Language: Английский

Experimental Study on Myocardial Protective Effect of Xuebijing Injection on Extracorporeal Membrane Oxygenation Perfused Isolated Heart: Based on Autophagy and NLRP3 Inflammatory Pathway DOI

Shijie Yin,

Chunhua Wang, Yue Xiao

et al.

Transplantation Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Colchicine inhibits myocardial pyroptosis and reduces myocardial cell injury after myocardial infarction through the ESR1-PI3K-Akt-NF-κB signaling pathway DOI Creative Commons
Qianming Chen,

ShanQing Bao,

Yijie Ding

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114732 - 114732

Published: April 27, 2025

Language: Английский

Citations

0
Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes DOI Open Access
Jarosław Nuszkiewicz,

Beata Kukulska-Pawluczuk,

Katarzyna Piec

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4258 - 4258

Published: July 21, 2024

Acute ischemic stroke (AIS) remains a major cause of mortality and long-term disability worldwide, driven by complex multifaceted etiological factors. Metabolic dysregulation, gastrointestinal microbiome alterations, systemic inflammation are emerging as significant contributors to AIS pathogenesis. This review addresses the critical need understand how these factors interact influence risk outcomes. We aim elucidate roles dysregulated adipokines in obesity, impact gut microbiota disruptions, neuroinflammatory cascade initiated lipopolysaccharides (LPS) AIS. Dysregulated obesity exacerbate inflammatory responses, increasing severity. Disruptions subsequent LPS-induced neuroinflammation further link Advances neuroimaging biomarker development have improved diagnostic precision. Here, we highlight for approach management, integrating metabolic, microbiota, insights. Potential therapeutic strategies targeting pathways could significantly improve prevention treatment. Future research should focus on elucidating developing targeted interventions mitigate impacts metabolic imbalances,

Language: Английский

Citations

3