The structural characteristics, biological activities and mechanisms of bioactive brown seaweed polysaccharides: A review DOI Creative Commons

Qingling Zhou,

Zhuo Wang,

Wenting Chen

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106303 - 106303

Published: June 15, 2024

Brown seaweed polysaccharides (BSPs) are potential alternative sources of bioactive compounds. The food and pharmaceutical industries have a great interest in BSPs because their various bioactivities, such as anticancer, antioxidant, immunomodulatory activities. Studies demonstrated that the bioactivities significantly influenced by structural characteristics chemical constitution; but, specific conformational relationships complex required further study. However, systematic reviews biological activities mechanisms action currently inadequate. Thus, this paper summarizes recent studies on physicochemical features, characterization methods, activities, related from different sources. Based these findings, future prospects include following three aspects. More advanced research techniques need to be developed identify exact main branch structure BSPs; in-depth detailed needed elucidate between clinical trials should conducted verify effectiveness prevention treatment diseases. information provided here aims offer theoretical foundation for properties, mechanism action, applications well as, increase economic value extend application range.

Language: Английский

Natural Regenerative Hydrogels for Wound Healing DOI Creative Commons
Mariana Chelu,

José María Calderón Moreno,

Adina Magdalena Musuc

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 547 - 547

Published: Aug. 23, 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.

Language: Английский

Citations

20
Composite hydrogels assembled from food-grade biopolymers: Fabrication, properties, and applications DOI
David Julian McClements

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103278 - 103278

Published: Aug. 14, 2024

Language: Английский

Citations

19
Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation DOI Open Access

Wencong Jia,

Ye Wu, Yujie Xie

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Language: Английский

Citations

6
Development and Characterization of Pectin and Beeswax-Based Coatings Enhanced with Anthocyanins and Its Antioxidant and Antifungal Properties DOI Open Access

Ariel Alain Vergel-Alfonso,

Rocío Arias-Avelenda,

Alicia Casariego-Año

et al.

Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 542 - 542

Published: Feb. 14, 2025

Currently, approximately one third of food is wasted; to counteract this, several novel packaging technologies have been developed extend its shelf life, among which active stands out. In this research, filmogenic solutions pectin and beeswax with the addition bioactive compounds as anthocyanins were characterized evaluate their potential application coatings. The antioxidant antifungal activity coatings determined, rheological properties, pH, color, SEM FT-IR evaluated. had IC50 values 79.52 56.14 μg/mL for DPPH• ABTS•+, respectively, 0.25% (w/v) against Colletotrichum siamense, was inhibited by 32.16% morphological affectations in fungus. best formulation coating obtained 3% pectin, 1% wax, Tween 80, 0.1, 0.25, 0.5% added. properties showed adequate viscosity (0.08–0.12 Pa·s), pH acidic (3.05–3.78) reddish tones. analysis that interactions between components included C=O stretching band being shifted due intermolecular micrographs film presented continuous areas embedded wax crystals. Promising results formulations suitable characteristics use food.

Language: Английский

Citations

4
Marine algal polysaccharides for drug delivery applications: A review DOI

Nada E Ramadan,

Fatma Youssef,

Amira A K Alshishtawy

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139551 - 139551

Published: Jan. 7, 2025

Language: Английский

Citations

3
From nature to nanotech: Harnessing the power of electrospun polysaccharide-based nanofibers as sustainable packaging DOI

Vahid Tayebi-Khorrami,

Saba Shahgordi,

Mohammad Mahdi Dabbaghi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140127 - 140127

Published: Jan. 21, 2025

Language: Английский

Citations

3
Chitosan Edible Coatings Loaded with Bioactive Components for Fruits and Vegetables: A Step Toward Sustainable Development Goals DOI

­ Sapna,

Chhavi Sharma, Puneet Pathak

et al.

Food and Bioprocess Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

3
Polysaccharides as Protective Agents against Heavy Metal Toxicity DOI Creative Commons
Lukman Iddrisu, Felix Danso, Kit‐Leong Cheong

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 853 - 853

Published: March 11, 2024

Polysaccharides are functional foods or drugs that can be used to alleviate heavy metal poisoning by cadmium, lead, mercury, and arsenic. Industries generate substantial quantities of toxic wastes, such as wastewater discharges, paints, electronic waste, batteries, pigments, plastics, into the environment pose a risk human health. Therefore, it is imperative eliminate accumulated ions from body environment. Heavy toxicity lead decreased energy levels impair functioning vital organs, brain, lungs, kidneys, liver, blood. Prolonged exposure result in progressive physical, muscular, neurological degeneration resembles conditions multiple sclerosis, Parkinson’s disease, Alzheimer’s muscular dystrophy. operate through mechanisms chelation, antioxidant defense, immunomodulation, tissue repair. involved removal include methionine cysteine, together with N-acetylcysteine, an acetylated form S-adenosylmethionine, metabolite methionine, α-lipoic acid, tripeptide glutathione (GSH). These compounds effectively bind harmful metals create stable complex defend biological targets ions, thus decreasing their effects causing them excreted body. This review also highlights importance polysaccharides’ ability mitigate oxidative stress, enhance immune responses, support repair processes. ubiquitous nature take part diverse processes, making potential natural therapies for metal-related diseases. discusses effectiveness polysaccharides allow have inherent features enable function pharmacological agents regulate response.

Language: Английский

Citations

14
A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years DOI Creative Commons
Magdalena Stevanović, Nenad Filipović

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 670 - 670

Published: May 16, 2024

In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.

Language: Английский

Citations

13
Nanopore-based glycan sequencing: state of the art and future prospects DOI Creative Commons

Guangda Yao,

Wenjun Ke, Bingqing Xia

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(17), P. 6229 - 6243

Published: Jan. 1, 2024

This perspective outlines three potential routes for nanopore-based glycan sequencing, highlighting their applications and offering insights to meet associated challenges. It also introduces the concept of sequencer.

Language: Английский

Citations

10