Resistance Exercise Training as a New Trend in Alzheimer’s Disease Research: From Molecular Mechanisms to Prevention DOI Open Access
Alexis Sepúlveda-Lara, Paulina Sepúlveda, Gabriel Nasri Marzuca-Nassr

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7084 - 7084

Published: June 27, 2024

Alzheimer's disease is a pathology characterized by the progressive loss of neuronal connections, which leads to gray matter atrophy in brain. most prevalent type dementia and has been classified into two types, early onset, associated with genetic factors, late environmental factors. One greatest challenges regarding high economic cost involved, why number studies aimed at prevention treatment have increased. possible approach use resistance exercise training, given that it shown neuroprotective effects disease, such as increasing cortical hippocampal volume, improving neuroplasticity, promoting cognitive function throughout life cycle. However, how training specifically prevents or ameliorates not fully characterized. Therefore, aim this review was identify molecular basis could prevent treat disease.

Language: Английский

The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders DOI Creative Commons

Tadahiro Numakawa,

Ryutaro Kajihara

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 848 - 848

Published: Feb. 12, 2025

Among neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4/5), BDNF has been extensively studied for its physiological role in cell survival synaptic regulation the central nervous system's (CNS's) neurons. binds to TrkB (a tyrosine kinase) with high affinity, resulting downstream intracellular signaling cascades play crucial roles determining fate, neuronal differentiation maturation of CNS It well demonstrated that downregulation/dysregulation BDNF/TrkB system is implicated pathogenesis neurologic psychiatric disorders, such as Alzheimer's disease (AD) depression. Interestingly, effects mimetic compounds flavonoids, small molecules which can activate TrkB-mediated signaling, have investigated potential therapeutic strategies brain diseases, given p75NTR, a common neurotrophin receptor, also contributes death under variety pathological conditions neurodegeneration. Since downregulation associated pathophysiology neurodegenerative diseases understanding how alterations contribute progression could provide valuable insight prevention these diseases. The present review shows recent advances molecular mechanisms underlying plasticity, providing critical insights into impact mimetics

Language: Английский

Citations

2
From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer’s Disease DOI
Angélica Ortega-Torres,

Brendan Chernicki,

Grace Ou

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Language: Английский

Citations

9
Antidepressant Effect of Crossopteryx Febrifuga Trunk Bark Aqueous Extract on Chronic Stress-Induced Depression in Rodents: A Sex-Based Approach DOI

Daniel Ndavoumta,

Harquin Simplice Foyet, Camdi Woumitna Guillaume

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective DOI
Falguni Goel,

Daksh Kumar,

Anushka Sharma

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Prevalence of bruxism in neurodegenerative disorders in the elderly: A systematic review and meta-analysis DOI Creative Commons

J V Ashwin,

Astha Singh,

Mohit Kumar Shahi

et al.

Industrial Psychiatry Journal, Journal Year: 2025, Volume and Issue: 34(1), P. 4 - 10

Published: Jan. 1, 2025

Bruxism, characterized by the rhythmic grinding and clenching of teeth, is a common parafunctional behavior with implications beyond oral health. Recent interest has emerged in exploring its association neurodegenerative disorders (NDDs), such as Parkinson’s disease (PD), Alzheimer’s (AD), frontotemporal dementia (FTD). This systematic review meta-analysis aimed to investigate prevalence bruxism individuals NDDs, synthesizing existing evidence identifying areas for further investigation. A comprehensive search strategy was implemented across electronic databases (PubMed, Scopus, Embase, Sci Info), supplemented manual searches reference lists. Studies were included based on predefined criteria related data extraction quality assessment performed independently two reviewers. Statistical analysis involved using manager software, risk ratios (RRs) calculated assess between NDDs. Three studies meta-analysis, revealing higher NDD subjects compared controls (RR: 1.52; 95% CI: 1.33–1.71). Subgroup indicated significant heterogeneity among studies, no overall effect observed (Z = 0.41, P > 0.05). Neuroanatomical neurobiological mechanisms linking NDDs explored, highlighting dopaminergic serotonergic pathways’ roles. provides supporting controls. The findings underscore need research elucidate underlying inform clinical practice managing effectively.

Language: Английский

Citations

0
The neuroplastic brain: current breakthroughs and emerging frontiers DOI Creative Commons
Parisa Gazerani

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149643 - 149643

Published: April 1, 2025

Language: Английский

Citations

0
Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence DOI Open Access
В. Э. Цейликман,

Olga B. Tseilikman,

Oleg N. Yegorov

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2856 - 2856

Published: Aug. 26, 2024

The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.

Language: Английский

Citations

3
Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models) DOI Creative Commons
A. Tolédano, Arantxa Rodríguez‐Casado,

María‐Isabel Álvarez

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1101 - 1101

Published: Oct. 30, 2024

Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy difficult to prevent control when they develop. It has been known for many years these diseases pathogenic aspects in common. We highlight this review neuroglial cells (astroglia, oligodendroglia, microglia) play a vital role the origin, clinical-pathological development, course brain neurodegeneration. Moreover, we include new results T2D-AD mouse model (APP+PS1 mice on high-calorie diet) investigating.

Language: Английский

Citations

3
Resistance Exercise Training as a New Trend in Alzheimer’s Disease Research: From Molecular Mechanisms to Prevention DOI Open Access
Alexis Sepúlveda-Lara, Paulina Sepúlveda, Gabriel Nasri Marzuca-Nassr

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7084 - 7084

Published: June 27, 2024

Alzheimer's disease is a pathology characterized by the progressive loss of neuronal connections, which leads to gray matter atrophy in brain. most prevalent type dementia and has been classified into two types, early onset, associated with genetic factors, late environmental factors. One greatest challenges regarding high economic cost involved, why number studies aimed at prevention treatment have increased. possible approach use resistance exercise training, given that it shown neuroprotective effects disease, such as increasing cortical hippocampal volume, improving neuroplasticity, promoting cognitive function throughout life cycle. However, how training specifically prevents or ameliorates not fully characterized. Therefore, aim this review was identify molecular basis could prevent treat disease.

Language: Английский

Citations

2