Published: Aug. 13, 2024
Language: Английский
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Oct. 25, 2024
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism disease pathogenesis is not understood, certain biomarkers provide valuable insight into pathogenesis, severity, progression therapeutic efficacy. These markers can be used to assess pathophysiological status brain including neurons, astrocytes, microglia, oligodendrocytes, specialized microvascular endothelial cells, pericytes, NVU, blood-brain barrier (BBB) disruption. Damage or derangements tight junction (TJ), adherens (AdJ), gap (GJ) components BBB lead increased permeability neuroinflammation various disorders disorders. Thus, neuroinflammatory evaluated blood, cerebrospinal fluid (CSF), tissues determine neurological progression, responsiveness. Chronic common age-related Alzheimer's (AD), Parkinson's (PD), dementia. Neurotrauma/traumatic injury (TBI) also leads acute chronic responses. The expression some may altered many years even decades before onset In this review, we discuss neuroinflammation, neurodegeneration associated with disorders, especially those neurovascular pathologies. CSF, tissues. Neurofilament light (NfL), ubiquitin C-terminal hydrolase-L1 (UCHL1), fibrillary acidic protein (GFAP), Ionized calcium-binding adaptor molecule 1 (Iba-1), transmembrane 119 (TMEM119), aquaporin, endothelin-1, platelet-derived growth factor receptor beta (PDGFRβ) are important markers. Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding neurotherapeutics. Integration these clinical practice could potentially enhance early diagnosis, monitor improve outcomes.
Language: Английский
Citations
5
PubMed, Journal Year: 2025, Volume and Issue: 7(1), P. fcaf029 - fcaf029
Published: Jan. 1, 2025
The glymphatic system may play a central role in cognitive impairment associated with Parkinson's disease, but its relationship regional cortical atrophy is not fully explored. To explore associations among dysfunction, degeneration and disease participants, we evaluated 51 participants documented (28 men; age, 61.65 ± 8.27 years) 30 age- sex-matched normal controls (11 59.2 5.90 who underwent 3.0-T MRI of the brain, including high-resolution T1-weighted imaging diffusion-tensor along perivascular space as surrogate for flow. Cortical grey matter volume was segmented automatically based on three-dimensional sequences. Cognitive function assessed by Mini-Mental State Examination. between decline revealed lower (1.45 0.17 versus 1.64 0.17, P < 0.0001) compared controls, indicating disturbed Glymphatic dysfunction scores (r = 0.54, 0.003). Diffusion-tensor values were positively specific regions (all P-values <0.05) temporal pole, posterior orbital gyrus, part inferior frontal operculum, operculum anterior cingulate gyrus. Mediation analysis within indicated that partially mediated integrity gyrus whereas distribution constitute link impairment.
Language: Английский
Citations
0
Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)
Published: April 1, 2025
Language: Английский
Citations
0
npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 23, 2025
Language: Английский
Citations
0
Burns & Trauma, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 1, 2025
Abstract In recent years, with the increasing volume of related research, it has become apparent that liver and gut play important roles in pathogenesis neurological disorders. Considering interactions among brain, liver, gut, brain–liver–gut axis been proposed gradually recognized. this article, we summarized complex network within axis, encompassing vagus nerve, barrier permeability, immunity inflammation, blood–brain barrier, microbial metabolites, neurotoxic beta-amyloid (Aβ) metabolism. We also elaborated on impact various Furthermore, outline several therapies aimed at modulating including antibiotics, probiotics prebiotics, fecal microbiota transplantation (FMT), nerve stimulation (VNS), dietary interventions. The focus is elucidating possible mechanisms underlying disorders identifying effective treatments are based our understanding axis.
Language: Английский
Citations
0
Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(4), P. 1630 - 1641
Published: July 1, 2024
Language: Английский
Citations
0
Российский физиологический журнал им И М Сеченова, Journal Year: 2024, Volume and Issue: 110(8), P. 1238 - 1252
Published: Oct. 19, 2024
Chronic sleep restriction (sleep less than 6 hours per day) due to the workload and a decrease in quality is an endemic disease modern society. deprivation causes serious neuropsychiatric disorders associated with irreversible neurodegenerative changes brain. The search for pharmacological agents that can reduce risk of neurodegeneration as result chronic loss urgent task issue biomedicine. Intranasal administration glucose-regulated 78 kDa heat shock protein (GRP78) has neuroprotective effect rat model Parkinson´s disease. potential intranasally administered GRP78 not been previously studied. aim study find out whether preventive intranasal able weaken and/or stop process locus coeruleus (SR) rats. was conducted on months old male Wistar For deprivation, validated method swinging platform used mode: 3 1 hour rest continuously 5 days. Recombinant human two days before start SR during SR. Cellular molecular were studied using immunohistochemistry Western blotting. It shown leads degeneration 30% noradrenergic neurons coeruleus, increase levels activated caspases-3 9. This indicates development apoptosis along mitochondrial pathway. No signs reactive microgliosis found We have demonstrated penetrates accumulates counteracts death path apoptosis. data obtained allows consider agent prevention pathological consequences deprivation.
Language: Английский
Citations
0
Journal of Dental Sciences, Journal Year: 2024, Volume and Issue: 20(2), P. 1043 - 1051
Published: Dec. 12, 2024
Parkinson's disease (PD) remains a challenging neurodegenerative disorder, requiring the exploration of innovative therapeutic strategies. This study assessed neuroprotective effects stem cells from human exfoliated deciduous teeth-conditioned medium (SHED-CM) in rotenone-induced mouse model PD. The SHED-CM, fractionated and purified via Fast Protein Liquid Chromatography (FPLC) into "yPD01", was administered intranasally to evaluate its impact on motor deficits, olfactory functions, protein expressions affected brain regions. Upon intranasal delivery, yPD01 produced significant improvements deficits restoration associated with PD pathology, particularly bulb substantial nigra. Intriguingly, route exhibited efficacy akin intravenous administration, highlighting potential as minimally invasive yet equally effective approach. Further investigation indicated key components within yPD01, denoted peaks P1 P5, showcasing pivotal effects. These were linked interruption alpha-synuclein aggregation clearance specific by Intranasally shows for mitigating symptoms, results provide valuable insights mechanisms underlying SHED-CM their implications future interventions related conditions.
Language: Английский
Citations
0
Published: Aug. 13, 2024
Language: Английский
Citations
0