Dynamic-Cross-Linked, Regulated, and Controllable Mineralization Degree and Morphology of Collagen Biomineralization DOI Creative Commons

Ziyao Geng,

Fan Xu, Ying Liu

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 356 - 356

Published: Nov. 22, 2024

The cross-linking process of collagen is one the more important ways to improve mineralization ability collagen. However, regulatory effect dynamic on biomineralization in vitro remains unclear. Dynamic-cross-linked mineralized under different processes, according and natural bone, was prepared this study. Mineralization performed for 12 h at 4, 8, cross-linking. Scanning electron microscopy (SEM) transmission (TEM) showed characteristics dynamic-cross-linked terms morphological transformation distribution. Fourier transform infrared spectroscopy (FTIR) analysis crystallinity hydroxyapatite (HA) crystal formation. Pre-cross-linked refers a period time then side cross-linked mineralization. mineral content, enzyme stability, mechanical properties were improved through pre-cross-linking. swelling performance reduced This study suggests that pre-cross-linking could make it easier minerals permeate deposit between fibers, efficiency, and, thus, enhance strength biomineralization. can provide new ideas theoretical basis designing scaffolds with better bone repair ability.

Language: Английский

Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review DOI Creative Commons
Xin Chen,

Shaoze Jing,

Chenhui Xue

et al.

Current Pain and Headache Reports, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Purpose of Review Intervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause lower back pain, which seriously affects the work life patients causes large economic burden to society. The traditional treatment IVDD mainly involves early pain relief late surgical intervention, but it cannot reverse pathological course IVDD. Current studies suggest that related imbalance between anabolic catabolic functions extracellular matrix (ECM). Anti-inflammatory drugs, bioactive substances, stem cells have all been shown improve ECM, injection methods face short half-life leakage problems. Recent Findings good biocompatibility slow-release function polymer hydrogels are being noticed explored combine with drugs or substances treat Summary This paper introduces pathophysiological mechanism IVDD, discusses advantages, disadvantages development prospects for so as provide guidance future breakthroughs in

Language: Английский

Citations

1
Sprayable Nanocomposites Hydrogel for Wound Healing and Skin Regeneration DOI Open Access

Sihua Li,

Meng Luo,

Juntang Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Wound management remains a critical challenge worldwide and imposes huge financial burden on every nation. Hydrogels are promising for biomedical applications because of their extracellular matrix (ECM) like structure, good biocompatibility multifunctional bioactivity. However, the poor mechanical properties inconvenient operation traditional hydrogels make it difficult to meet complex multifaceted needs clinical practice. In recent years, nanocomposites hydrogel with especially sprayable feature have shown enhanced facile operation, which enable value. A unique powerful nanocomposite (NCH) platform is developed by combining many advantages nanomaterials hydrogels, can achieve efficient trauma repair. This work reviews important advances preparation, functions NCH platforms. The challenges future trends in field aim providing researchers clarity past, present, emerging also proposed detail.

Language: Английский

Citations

1
Preparation, purification and identification of antioxidant peptides from the placenta of Tibetan sheep DOI
Haiwei Ren,

T. C. Qin,

Qin Zhou

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105560 - 105560

Published: Nov. 1, 2024

Language: Английский

Citations

1
Sideritis raeseri—Modified Coatings on Ti-6Al-4V as a Carrier for Controlled Delivery Systems of Active Substances DOI Open Access
Karina Niziołek, Dagmara Słota,

Julia Sadlik

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(10), P. 2250 - 2250

Published: May 10, 2024

The search for the ideal metallic material an implant is still a difficult challenge scientists due to phenomenon of corrosion and consequent disruption structure. Prevention application coatings that protect implant, activate tissues faster regeneration, also prevent inflammation through antibacterial antiviral effects. present study focuses on selection components Ti-6Al-4V alloy coating. These days, researchers are taking intense interest in extracts natural origin. It was decided take look at Sideritis raeseri, which contains vitamins valuable elements rich polyphenols, as well antioxidants. composition based PEG polymer reinforced with brushite S. raeseri extract proteins L-carnosine, fibroin, or sericin developed. samples were subjected detailed physiochemical analysis, including potentiometry electrical conductivity Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD) UV-VIS spectroscopy. demonstrated polyphenols successfully released from during incubation vitro. osteointegration process can be supported by number factors, such release bacterial, viral, fungal infections. Subjecting 14 days their interactions fluids, ion exchange between medium materials. An analysis surface morphology exhibited presence crystals increased after incubation, indicating bioactivity formed coatings.

Language: Английский

Citations

0
Dynamic-Cross-Linked, Regulated, and Controllable Mineralization Degree and Morphology of Collagen Biomineralization DOI Creative Commons

Ziyao Geng,

Fan Xu, Ying Liu

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(12), P. 356 - 356

Published: Nov. 22, 2024

The cross-linking process of collagen is one the more important ways to improve mineralization ability collagen. However, regulatory effect dynamic on biomineralization in vitro remains unclear. Dynamic-cross-linked mineralized under different processes, according and natural bone, was prepared this study. Mineralization performed for 12 h at 4, 8, cross-linking. Scanning electron microscopy (SEM) transmission (TEM) showed characteristics dynamic-cross-linked terms morphological transformation distribution. Fourier transform infrared spectroscopy (FTIR) analysis crystallinity hydroxyapatite (HA) crystal formation. Pre-cross-linked refers a period time then side cross-linked mineralization. mineral content, enzyme stability, mechanical properties were improved through pre-cross-linking. swelling performance reduced This study suggests that pre-cross-linking could make it easier minerals permeate deposit between fibers, efficiency, and, thus, enhance strength biomineralization. can provide new ideas theoretical basis designing scaffolds with better bone repair ability.

Language: Английский

Citations

0