Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 886 - 886
Published: Jan. 21, 2025
Obstructive
sleep
apnea
(OSA)
is
common
during
pregnancy
and
linked
to
adverse
outcomes.
While
oxidative
stress
a
proposed
pathogenic
mechanism,
evidence
in
pregnant
populations
remains
limited.
This
multicenter,
prospective
study
evaluated
through
protein
carbonyl
levels
171
women
86
cord
blood
samples.
Polysomnography
(PSG)
performed
categorized
participants
with
the
apnea–hypopnea
index
(AHI)
OSA,
rapid
eye
movement
(REM)
supine
OSA.
Protein
were
measured
by
dinitrophenyl
hydrazine
(DNPH)
method.
No
significant
differences
found
maternal
or
between
OSA
non-OSA
groups,
REM
subgroups.
Interestingly,
shorter
(AH)
length
showed
both
higher
lower
nocturnal
oxygen
saturation.
Overall,
was
not
associated
increased
as
levels.
However,
duration
hypoxia
may
influence
stress,
pointing
complex
relationship
pregnancy,
beyond
traditional
metrics
like
AHI.
Future
studies
should
explore
additional
biomarkers
diverse
molecular
pathways
that
could
play
role,
special
attention
emerging
factors
such
hypoxic
burden
elucidate
interrelationships
more
comprehensively.
Language: Английский
Identifying and validating immunological biomarkers in obstructive sleep apnea through bioinformatics analysis
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 21, 2025
Obstructive
sleep
apnea
(OSA)
is
a
prevalent
disorder
characterized
by
disrupted
breathing
patterns
and
dysfunctions
in
multiple
organ
systems.
Although
studies
support
close
correlation
between
OSA
immune
function,
the
broader
implications
specific
manifestations
remain
unclear.
Therefore,
it
pressingly
needed
to
identify
potential
immune-related
markers
elucidate
underlying
immunological
mechanisms
of
OSA.
OSA-related
datasets
(GSE38792)
genes
were
downloaded
from
GEO
ImmPort
databases
intersected
obtain
differentially
expressed
(DEIRGs).
GO,
KEGG,
GSEA
employed
explore
biological
functions
DEIRGs.
Immune
cells
regulation
analyzed
CIBERSORT.
The
ROC
curve
was
constructed
assess
accuracy
each
DEIRG.
co-regulatory
networks
transcription
factors,
microRNAs,
drugs
built
using
NetworkAnalyst
database
visualized
Cytoscape.
levels
DEIRGs
clinical
samples
validated
RT-qPCR.
revealed
that
DEGs
mainly
enriched
negative
response
antigen
processing
presentation
IL33,
IL10RB,
ANGPTL1,
EIF2AK2,
SEM1,
IFNA16,
SLC40A1,
FCER1G,
IL1R1,
TNFRSF17,
ERAP2
identified
as
among
175
Memory
B
cells,
mast
resting,
dendritic
resting
predominant
related
network
contained
128
miRNAs,
40
172
drugs/compounds.
Finally,
ANGPTL1
also
upregulated
samples.
present
study
biomarkers
systematically
elucidated
These
findings
provide
novel
insights
into
diagnosis,
mechanism
research,
management
strategies
for
future
studies.
Language: Английский
Effects of Gestational Intermittent Hypoxia on the Respiratory System: A Tale of the Placenta, Fetus and Developing Offspring
Published: May 2, 2024
Obstructive
sleep
apnea
(OSA)
is
a
common
disorder
that
associated
with
wide
variety
of
health
conditions,
including
cardiovascular,
cerebrovascular,
metabolic,
neoplastic,
and
neurocognitive
manifestations.
OSA
mainly
characterized
by
repeated
upper
airway
obstructions
during
cause
episodes
chronic
intermittent
hypoxia
(IH),
resulting
in
tissue
hypoxia-reoxygenation.
Decreased
arterial
oxygen
pressure
(PaO2)
hemoglobin
saturation
(SatO2)
stimulate
reflex
responses
to
overcome
the
obstruction.
The
prevalence
significant
worldwide,
particularly
women
pregnancy,
due
physiological
changes
this
stage
life,
especially
its
later
stages.
It
an
increased
risk
hypertension,
pre-eclampsia
diabetes,
among
others.
pregnancy
can
interfere
normal
fetal
development
growth
retardation,
preterm
birth,
or
low
term
weight.
Carotid
body
stimulation
hypoxia-reoxygenation
contribute
cardiovascular
disease
oxidative
stress,
harm
both,
mother
fetus,
even
into
adulthood.
Because
gestational
(GIH)
hallmark
review
examines
impact
GIH
on
maternal,
fetal,
offspring
respiratory
outcomes.
Most
adverse
outcomes
be
prevented
continuous
positive
(CPAP)
therapy
lifestyle
if
detected
early
treated
appropriately.
Language: Английский
Gestational Intermittent Hypoxia Impairs AT2R-Mediated Vascular Protection in Female Offspring on a High-Fat, High-Sucrose Diet
Journal of Biotechnology and Biomedicine,
Journal Year:
2024,
Volume and Issue:
07(02)
Published: Jan. 1, 2024
Gestational
intermittent
hypoxia
(GIH),
a
hallmark
of
maternal
obstructive
sleep
apnea,
sex-differentially
causes
hypertension
and
endothelial
dysfunction
in
adult
male
offspring
but
not
females.
This
study
investigated
whether
the
GIH-exposed
female
offspring,
"protected"
group
against
hypertensive
effects
GIH
exposure,
exhibit
increased
susceptibility
to
cardiovascular
when
fed
high-fat
high-sucrose
(HFHS)
diet
this
effect
could
be
reversed
by
pharmacological
intervention
activating
angiotensin
II
type
2
receptor
(AT
Language: Английский
Nocturnal blood pressure: the hidden link between sleep apnea and hypertensive disorders of pregnancy?
SLEEP,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
Journal
Article
Corrected
proof
Nocturnal
blood
pressure:
the
hidden
link
between
sleep
apnea
and
hypertensive
disorders
of
pregnancy?
Get
access
Federica
Piani,
Piani
Hypertension
Cardiovascular
Risk
Research
Center,
Medical
Surgical
Sciences
Dept.,
Alma
Mater
Studiorum
University
Bologna,
Italy
Search
for
other
works
by
this
author
on:
Oxford
Academic
Google
Scholar
Martino
F
Pengo
Department
Cardiovascular,
Neural
Metabolic
Sciences,
IRCCS
Istituto
Auxologico
Italiano,
Milan,
ItalyDepartment
Medicine
Surgery,
Milano-Bicocca,
Corresponding
author.
F.
Pengo,
Milano-Bicocca;
Ospedale
San
Luca,
Via
Magnasco
2
Milan.
Email:
[email
protected],
protected].
https://orcid.org/0000-0002-4657-9172
Sleep,
zsae303,
https://doi.org/10.1093/sleep/zsae303
Published:
20
December
2024
history
typeset:
06
January
2025
Language: Английский