Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism DOI Creative Commons
Vincenzo Quagliariello,

Maria Laura Canale,

Irma Bisceglia

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1650 - 1650

Published: July 24, 2024

Cardiovascular disease and cancer are the two leading causes of morbidity mortality in world. The emerging field cardio-oncology described several shared risk factors that predispose patients to both cardiovascular cancer. Post-acute COVID-19 syndrome is a chronic condition occurs many who have experienced SARS-CoV-2 infection, mainly based on fatigue, sedentary lifestyle, cramps, breathing difficulties, reduced lung performance. exposes increased visceral adiposity, insulin resistance, myosteatosis, white adipose tissue content (surrounded by M1 macrophages characterized Th1/Th17 phenotype), which increases recurrence. In this review, main metabolic affections post-acute at low high cardiomyopathies will be summarized. Furthermore, non-pharmacological strategies aimed reducing atherosclerotic cardiac provided, especially through anti-inflammatory nutrition with glycemic index, appropriate physical activity, immune-modulating bioactivities able reduce obesity improving insulin-related signaling myocardial metabolism.

Language: Английский

Adult Long Coronavirus Disease 2019 DOI
Ivette F. Emery, Clifford J. Rosen

Infectious Disease Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
FABP4 as a therapeutic host target controlling SARS-CoV-2 infection DOI Creative Commons

Hatoon Baazim,

Emre Koyuncu,

Gürol Tuncman

et al.

EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
COVID-19 and persistent symptoms: implications for polycystic ovary syndrome and its management DOI Creative Commons
Shanshan Zhang,

Yanqun Wu,

Richard Mprah

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

The COVID-19 pandemic has left a profound mark on global health, leading to substantial morbidity and mortality worldwide. Beyond the immediate symptoms of infection, emergence “long COVID”, long-term effects SARS-CoV-2, become significant public health concern. Long COVID is multifaceted condition affecting various organs systems, including cardiovascular, digestive, nervous, endocrine systems. Individuals diagnosed with polycystic ovary syndrome (PCOS) may face an increased risk severe infection. It crucial comprehend how long affects PCOS patients devise effective treatment care strategies. Here, we review detrimental its reproductive function, inflammation, metabolism, cardiovascular body composition, lifestyle, mental in PCOS. We offer recommendations for post-covid-19 management PCOS, emphasizing necessity comprehensive, multidisciplinary approach patient care. Furthermore, discuss prospective research directions, highlighting significance continued investigations clinical trials evaluate approaches ramifications individuals

Language: Английский

Citations

3
FABP4 as a Therapeutic Host Target Controlling SARS-CoV2 Infection DOI Creative Commons

Hatoon Baazim,

Emre Koyuncu,

Gürol Tuncman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 12, 2024

Abstract Host metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related disorders are recognized as high-risk modifiers for respiratory infections, including coronavirus though the underlying mechanisms remain unknown. Our study highlights fatty acid-binding protein 4 (FABP4), key regulator dysfunction inflammation, modulator SARS-CoV-2 pathogenesis, correlating strongly with severity in COVID-19 patients. We demonstrate that loss FABP4 function, by genetic or pharmacological means, reduces SARS-CoV2 replication disrupts formation viral organelles adipocytes airway epithelial cells. Importantly, inhibitor treatment infected hamsters diminished lung titers, alleviated damage reduced collagen deposition. These findings highlight therapeutic potential targeting host metabolism limiting mitigating pathogenesis infection.

Language: Английский

Citations

1
Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism DOI Creative Commons
Vincenzo Quagliariello,

Maria Laura Canale,

Irma Bisceglia

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1650 - 1650

Published: July 24, 2024

Cardiovascular disease and cancer are the two leading causes of morbidity mortality in world. The emerging field cardio-oncology described several shared risk factors that predispose patients to both cardiovascular cancer. Post-acute COVID-19 syndrome is a chronic condition occurs many who have experienced SARS-CoV-2 infection, mainly based on fatigue, sedentary lifestyle, cramps, breathing difficulties, reduced lung performance. exposes increased visceral adiposity, insulin resistance, myosteatosis, white adipose tissue content (surrounded by M1 macrophages characterized Th1/Th17 phenotype), which increases recurrence. In this review, main metabolic affections post-acute at low high cardiomyopathies will be summarized. Furthermore, non-pharmacological strategies aimed reducing atherosclerotic cardiac provided, especially through anti-inflammatory nutrition with glycemic index, appropriate physical activity, immune-modulating bioactivities able reduce obesity improving insulin-related signaling myocardial metabolism.

Language: Английский

Citations

1