Anti-Inflammatory, Analgesic, Functional Improvement, and Chondroprotective Effects of Erigeron breviscapus (Vant.) Hand.-Mazz. Extract in Osteoarthritis: An In Vivo and In Vitro Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1035 - 1035

Published: April 2, 2024

Osteoarthritis (OA) is a degenerative bone disease characterized by inflammation as primary pathology and currently lacks therapeutic interventions to impede its progression. Erigeron breviscapus (Vant.) Hand.-Mazz. (EB) an east Asian herbal medicine with long history of use wide range confirmed efficacy against cardiovascular central nervous system diseases. The purpose this study evaluate whether EB worthy further investigation treatment for OA based on anti-inflammatory activity. This aims assess the potential OA, focusing properties. Analgesic effects, functional improvements, inhibition cartilage destruction induced were evaluated in acetic acid-induced peripheral pain mice monosodium iodoacetate-induced rat models. Additionally, effect was assessed serum tissue vivo, well lipopolysaccharide-induced RAW 264.7 cells. demonstrated significant alleviation pain, impairment, degradation along notable pro-inflammatory cytokines, including interleukin-1β, interleukin-6, matrix metalloproteinases 13, nitric oxide synthase 2, both vitro dose-dependent manner compared active control. Accordingly, merits exploration disease-modifying drug capable mitigating multifaceted osteoarthritis through Nonetheless, additional validation broader experimental design essential substantiate findings study.

Language: Английский

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Jianpi Qingre Tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118953 - 118953

Published: Oct. 1, 2024

Language: Английский

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Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2435 - 2435

Published: July 26, 2024

Osteoarthritis (OA), characterized by chronic pain and joint degradation, is a progressive disease primarily induced age-related systemic inflammation.

Language: Английский

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Inhibitory Effects of Reynoutria japonica Houtt. on Pain and Cartilage Breakdown in Osteoarthritis Based on Its Multifaceted Anti-Inflammatory Activity: An In Vivo and In Vitro Approach

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10647 - 10647

Published: Oct. 3, 2024

In the past 30 years, number of years lived with disability due to osteoarthritis (OA) has doubled, making it an increasing global health burden. To address this issue, interventions that inhibit progressive pathology driven by age-related low-grade inflammation, primary mechanism OA, are being actively pursued. Recent investigations have focused on modulating inflammatory disease as a therapeutic target. However, no agent successfully halted disease’s progression or reversed its irreversible course. Reynoutria japonica Houtt. (RJ), promising East Asian herbal medicine, been utilized for several diseases potent anti-inflammatory activity. This study aims determine RJ’s capacity OA symptoms and associated exploring potential further development. vivo in vitro experiments demonstrated anti-OA activity modulation multifaceted targets. RJ significantly inhibited pain, gait deterioration, cartilage destruction monosodium iodoacetate-induced rat model, analgesic effect confirmed acetic acid-induced writhing model. exhibited consistent against multiple targets serum model lipopolysaccharide-induced RAW 264.7 cells. The inhibition cytokines, including interleukin-1β, interleukin-6, matrix metalloproteinase-13, tumor necrosis factor-α, nitric oxide synthase 2, suggests alleviation manifestations relates These results indicate merits investigation disease-modifying drug candidate targeting OA’s pathology. characterize pharmacological properties RJ, future studies expanded designs warranted.

Language: Английский

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Investigating the Anti-Inflammatory, Analgesic, and Chondroprotective Effects of Gynostemma pentaphyllum (Thunb.) Makino in Osteoarthritis: An In Vitro and In Vivo Study

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9594 - 9594

Published: Sept. 4, 2024

Osteoarthritis (OA) is an age-related disease characterized by inflammation, pain, articular cartilage damage, synovitis, and irreversible disability. Gynostemma pentaphyllum (Thunb.) Makino (GP), a herbal medicine traditionally used in East Asia for its anti-inflammatory properties, was investigated potential to modulate OA pathology symptoms. This study evaluated GP’s efficacy inhibiting functional decline, destruction monosodium iodoacetate-induced acetic acid-induced writhing models. Additionally, the effects of GP on OA-related inflammatory targets were assessed via mRNA protein expression rat knee lipopolysaccharide-induced RAW 264.7 cells. The group demonstrated significant pain relief, improvement, protection. Notably, inhibited key mediators, including interleukin (IL)-1β, IL-6, matrix metalloproteinases (MMP)-3 MMP-13, cyclooxygenase-2, prostaglandin E receptor 2, surpassing active controls. These findings suggest that promising candidate disease-modifying drugs warrants further comprehensive studies.

Language: Английский

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Maternal Supplementation of Lonicera japonica and Scutellaria Baicalensis Mixed Extracts Improve Reproduction Performance and Metabolic Health through Modulating Gut Microbiota during Pregnancy

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Background This study aimed to evaluate the impacts of dietary supplementation with a combination plant extracts on performance, metabolic health, and gut microbiota sows. One thousand three crossbred pregnancy sows (DanBred Landrace × DanBred Yorkshire, mean parity 4.44 ± 1.84) were assigned one two treatments: control group (CON, basal diet) Lonicera japonica Scutellaria baicalensis mixed (LSE, diet supplemented 0.5 g/kg extracts). The litter performance at farrowing weaning measured. plasmas samples feces from obtained d 30 (G30 d) 109 (G109 gestation, 3 lactation (L3 d). Results Supplementation LSE increased (P < 0.05) numbers total born, weight average pig day 21 lactation, daily feed intake, survival rate piglets during lactation. Compared CON, reduced interleukin-6 (IL-6) concentration in G109 d, while interleukin-10 (IL-10) L3 d. had lower reactive oxygen species (ROS) levels G30 reducing tendency = 0.07) for thiobarbituric acid substances (TBARS) concentrations trend toward 0.08) value homeostatic model assessment insulin sensitivity (HOMA-IS) sow In addition, abundance Firmicutes Proteobacteria decreased Bacteroidetes Spirochaetes Christensenellaceae_R_7_group, UCG_002, Clostridium_sensu_stricto_1, Escherichia_Shigella, un_f__Christensenellaceae, Bacteroides, Terrisporobacter significantly group. UCG_002 un_f__Ruminococcaceae positively correlated plasma IL-10 (P 0.01), negatively IL-6 TBARS levels. Conclusions Dietary gestation improved reproduction health sows, which might be associated changes microbiota.

Language: Английский

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Special Issue Entitled “Immune Regulatory Properties of Natural Products”

Processes, Journal Year: 2024, Volume and Issue: 12(5), P. 929 - 929

Published: May 2, 2024

Although the immunomodulatory effects of natural products have not yet been completely elucidated, attempts to use in treatment immune-mediated inflammatory diseases such as autoimmune diseases, chronic mutant viral infections, and even immunosenescence-related cancers are ongoing [...]

Language: Английский

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