Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics
Probiotics and Antimicrobial Proteins,
Journal Year:
2024,
Volume and Issue:
16(5), P. 1744 - 1761
Published: April 22, 2024
Language: Английский
Genome-wide association analysis identified inflammatory mechanisms mediating the effects of lipid metabolism on endometrial carcinoma in situ
Tingyu Lang,
No information about this author
Shaoqi Hua,
No information about this author
Xiaolei Liang
No information about this author
et al.
Journal of Chromatography B,
Journal Year:
2025,
Volume and Issue:
1258, P. 124601 - 124601
Published: April 17, 2025
Language: Английский
Integrative bioinformatics and experimental approaches reveal NFKBIZ as a key regulator of inflammatory factors and chemokines in pelvic inflammatory disease progression
Gene Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102194 - 102194
Published: March 1, 2025
Language: Английский
Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: July 2, 2024
Abstract
Introduction
This
study
investigated
changes
in
plasma
microbial-derived
extracellular
vesicles
(EVs)
patients
with
polycystic
ovary
syndrome
and
insulin
resistance
(PCOS-IR)
before
after
metformin
treatment,
aimed
to
identify
bacterial
taxa
within
EVs
that
were
biologically
statistically
significant
for
diagnosis
treatment.
Methods
The
case–control
was
conducted
at
Xiamen
Chang
Gung
Hospital,
Hua
Qiao
University.
Plasma
samples
collected
from
five
PCOS-IR
of
childbearing
age
3
months
the
sequenced.
diversity
taxonomic
composition
different
microbial
communities
analyzed
through
full-length
16
S
glycosomal
RNA
gene
sequencing.
Results
After
fasting
glucose
levels
IR
degree
significantly
improved.
analysis
metformin-treated
showed
higher
diversity.
There
differences
derived
some
environmental
bacteria
Notably,
Streptococcus
salivarius
more
abundant
group,
suggesting
it
may
be
a
potential
probiotic.
Discussion
demonstrated
findings
offer
new
insights
into
pathogenesis
provide
avenues
research.
Language: Английский
Microbiota Status and Endometrial Cancer: A Narrative Review About Possible Correlations in Affected Versus Healthy Patients
Sci,
Journal Year:
2024,
Volume and Issue:
6(4), P. 75 - 75
Published: Nov. 7, 2024
(1)
Background:
Microbiota
could
be
related
to
tumorigenesis
through
the
persistence
of
an
inflammatory
state,
also
at
endometrial
level.
Inflammation,
in
fact,
is
involved
promotion
genetic
instability
and
a
favorable
microenvironment
for
tumor
growth.
One
pathway
disruption
epithelial/mucosal
barrier,
with
activation
cytokines.
The
microbiota
seem
favor
other
patterns,
such
as
insulin
resistance
increased
adipose
tissue.
(2)
Methods:
online
search
this
review
was
based
on
keywords
“endometrial
cancer”
“microbiota”
main
scientific
database.
Our
objective
narrative
up-to-date
current
literature
gynecological
microbiota;
we
analyze
possible
correlations
known
modifying
promoting
oncological
factors
(i.e.,
Body
Mass
Index-
BMI,
menopause,
pH),
particular
attention
vaginal
uterine
microorganisms
respective
development
cancer
comparison
healthy
women.
(3)
Results:
Various
species
distributions
bacteria
induce
alterations
cell
signaling
cycle
pathways,
including
those
field.
(4)
Conclusions:
In
literature,
different
composition
has
been
analyzed
past
years,
their
diversity
actions
correlate
effects.
Language: Английский
Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites
Damilola Christianah Lawore,
No information about this author
Smrutiti Jena,
No information about this author
Alicia R. Berard
No information about this author
et al.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Abstract
The
vaginal
microbiome’s
role
in
risk,
progression,
and
treatment
of
female
cancers
has
been
widely
explored.
Yet,
there
remains
a
need
to
develop
methods
understand
the
interaction
microbiome
factors
with
host
cells
characterize
their
potential
therapeutic
functions.
To
address
this
challenge,
we
developed
systems
biology
framework
term
Pharmacobiome
for
pharmacology
analysis.
evaluates
similarities
between
microbes
microbial
byproducts
known
drugs
based
on
impact
transcriptomic
cellular
signatures.
Here,
apply
our
characterization
Anti-Gynecologic
Cancer
Vaginal
Pharmacobiome.
Using
published
multi-omics
data
from
Partners
PrEP
clinical
trial,
constructed
epithelial
gene
signatures
associated
each
profiled
microbe
metabolite.
We
compared
these
microbiome-associated
post-drug
perturbation
35
FDA-approved
anti-cancer
Library
Integrated
Network-based
Cellular
Signatures
database
identify
metabolites
high
statistical
functional
similarity
drugs.
found
that
Lactobacilli
can
regulate
expression
ways
similar
many
Additionally,
experimentally
tested
model
prediction
taurine,
metabolite
produced
by
L.
crispatus,
kills
cancerous
breast
endometrial
cancer
cells.
Our
study
shows
is
powerful
characterizing
generalizability
other
cancers,
microbiomes,
diseases.
Language: Английский
Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring?
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1628 - 1628
Published: July 23, 2024
Endocrine-disrupting
chemicals
(EDCs)
have
become
so
pervasive
in
our
environment
and
daily
lives
that
it
is
impossible
to
avoid
contact
with
such
compounds,
including
pregnant
women
seeking
minimize
exposures
themselves
their
unborn
children.
Developmental
exposure
of
humans
rodent
models
bisphenol
A
(BPA)
other
EDCs
linked
increased
anxiogenic
behaviors,
learning
memory
deficits,
decreased
socio-sexual
behaviors.
Prenatal
BPA
leads
longstanding
harmful
effects
on
gut
microbiota
reductions
beneficial
bacteria,
i.e.,
dysbiosis,
microbial
changes
are
host
fecal
metabolites,
those
involved
carbohydrate
metabolism
synthesis,
neurobehavioral
alterations
adulthood,
particular,
social
cognitive
deficits.
Gut
dysbiosis
increasingly
being
recognized
as
a
key
driver
myriad
diseases,
ranging
from
metabolic,
cardiovascular,
reproductive,
disorders
via
the
gut-microbiome-brain
axis.
Thus,
might
induce
indirect
physical
mental
health
by
acting
microbiome-disrupting
chemicals.
Findings
raise
important
question
whether
should
consume
probiotic
supplement
mitigate
pernicious
EDCs,
especially
BPA,
offspring.
Current
studies
investigating
maternal
supplementation
women's
offspring
will
be
reviewed.
Data
inform
potential
application
reverse
unwittingly
exposed
these
compounds
striving
give
best
start
life.
Language: Английский
Вагинальный микробиом: общие положения и взаимосвязь с гинекологическим раком
Матылевич О.П.,
No information about this author
Гришель А.С.,
No information about this author
Мавричев С.А.
No information about this author
et al.
Клиническая инфектология и паразитология,
Journal Year:
2024,
Volume and Issue:
13(3), P. 373 - 389
Published: Oct. 18, 2024
В
последние
годы
взаимосвязь
между
микробиотой
и
ее
влиянием
на
здоровье
человека
стала
предметом
множества
научных
исследований.
Хотя
сегодняшний
день
наиболее
изучена
микробиота
желудочно-кишечного
тракта,
в
последнее
время
интерес
распространился
другие
виды.
Нарушение
качественного
количественного
состава
микробиоты
пищеварительного
тракта
ведет
также
к
изменению
урогенитального
микробиоценоза.
Сложные
взаимодействия
кишечника
системным
воспалением
открывают
новые
аспекты
понимании
развития
онкологических
процессов
женской
репродуктивной
системы.
Кроме
того,
существует
тесная
связь
уровнем
циркулирующего
эстрогена
(эстроболомом),
изменение
которого
может
приводить
развитию
некоторых
видов
опухолей
системы
женщин.
Необходимы
дальнейшие
исследования,
чтобы
лучше
понимать
раком,
что,
вероятно,
улучшит
диагностику
лечение
онкологической
патологии.
In
recent
years,
the
relationship
between
microbiota
and
its
impact
on
human
health
has
become
subject
of
many
scientific
studies.
Although
gastrointestinal
been
most
studied
to
date,
interest
recently
spread
other
types
microbiota.
Violation
qualitative
quantitative
composition
also
leads
changes
in
urogenital
microbiocenosis.
Complex
interactions
intestinal
systemic
inflammation
open
up
new
aspects
understanding
development
oncological
processes
female
reproductive
system.
addition,
there
is
a
close
level
circulating
estrogen
(estrobolome),
which
can
lead
some
tumors
Further
research
needed
better
understand
cancer,
likely
improve
diagnosis
treatment
pathology.
Language: Русский
Advancements in Ovarian Cancer Research: Targeting DNA Repair Mechanisms and the Role of DNA Polymerase β Inhibitors
Biosciences Biotechnology Research Asia,
Journal Year:
2024,
Volume and Issue:
21(4), P. 1439 - 1449
Published: Dec. 20, 2024
ABSTRACT:
Background:
Exposure
to
mutagens
causes
DNA
damage,
which,
if
not
repaired
properly,
can
lead
diseases
like
cancer.
Ovarian
cancer
is
a
major
concern
for
women
globally,
including
in
India,
as
it
often
diagnosed
at
an
advanced
stage,
making
treatment
more
challenging.
Recent
research
implicates
repair
proteins
polymerase
β
(Pol
β)
development,
emphasising
the
need
understand
these
pathways
targeted
therapy.
This
study
uses
bibliometric
analysis
explore
ovarian
and
pathways,
providing
insights
future
treatment.
Materials
Methods:
Data
from
37,539
articles
related
cancer,
β,
inhibitors
were
analysed
Dimensions
database.
Publication
distribution,
national
cooperation,
leading
authors,
trends
examined.
Results:
Variations
publication
distribution
observed
across
journals,
with
notable
contributions
countries
Germany,
Canada,
Netherlands.
Prolific
authors
institutions
identified,
shedding
light
on
global
academic
landscape.
Co-occurrence
revealed
thematic
clusters,
pathophysiology,
risk
associations,
therapeutic
targets,
genomic
research.
Conclusion:
offers
valuable
into
pathways.
It
highlights
importance
of
targeting
mechanisms
therapy
suggests
opportunities
collaboration
personalised
medicine.
Identifying
key
directions
aids
advancing
our
understanding
aiming
improve
patient
outcomes.
Language: Английский