Advancements in Ovarian Cancer Research: Targeting DNA Repair Mechanisms and the Role of DNA Polymerase β Inhibitors DOI Open Access
Anutosh Patra, Abhishek Samanta, Anindita Chakraborty

et al.

Biosciences Biotechnology Research Asia, Journal Year: 2024, Volume and Issue: 21(4), P. 1439 - 1449

Published: Dec. 20, 2024

ABSTRACT: Background: Exposure to mutagens causes DNA damage, which, if not repaired properly, can lead diseases like cancer. Ovarian cancer is a major concern for women globally, including in India, as it often diagnosed at an advanced stage, making treatment more challenging. Recent research implicates repair proteins polymerase β (Pol β) development, emphasising the need understand these pathways targeted therapy. This study uses bibliometric analysis explore ovarian and pathways, providing insights future treatment. Materials Methods: Data from 37,539 articles related cancer, β, inhibitors were analysed Dimensions database. Publication distribution, national cooperation, leading authors, trends examined. Results: Variations publication distribution observed across journals, with notable contributions countries Germany, Canada, Netherlands. Prolific authors institutions identified, shedding light on global academic landscape. Co-occurrence revealed thematic clusters, pathophysiology, risk associations, therapeutic targets, genomic research. Conclusion: offers valuable into pathways. It highlights importance of targeting mechanisms therapy suggests opportunities collaboration personalised medicine. Identifying key directions aids advancing our understanding aiming improve patient outcomes.

Language: Английский

Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics DOI
Vineet Singh, Kanika Mahra, Da-Ryung Jung

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(5), P. 1744 - 1761

Published: April 22, 2024

Language: Английский

Citations

9
Genome-wide association analysis identified inflammatory mechanisms mediating the effects of lipid metabolism on endometrial carcinoma in situ DOI

Tingyu Lang,

Shaoqi Hua,

Xiaolei Liang

et al.

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1258, P. 124601 - 124601

Published: April 17, 2025

Language: Английский

Citations

1
Integrative bioinformatics and experimental approaches reveal NFKBIZ as a key regulator of inflammatory factors and chemokines in pelvic inflammatory disease progression DOI Creative Commons
Bao-Qin Liu, Qing Wang, Huijing Dong

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102194 - 102194

Published: March 1, 2025

Language: Английский

Citations

0
Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance DOI Creative Commons
Liping Hu, Guolin Hong, Jingzhi Li

et al.

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 2, 2024

Abstract Introduction This study investigated changes in plasma microbial-derived extracellular vesicles (EVs) patients with polycystic ovary syndrome and insulin resistance (PCOS-IR) before after metformin treatment, aimed to identify bacterial taxa within EVs that were biologically statistically significant for diagnosis treatment. Methods The case–control was conducted at Xiamen Chang Gung Hospital, Hua Qiao University. Plasma samples collected from five PCOS-IR of childbearing age 3 months the sequenced. diversity taxonomic composition different microbial communities analyzed through full-length 16 S glycosomal RNA gene sequencing. Results After fasting glucose levels IR degree significantly improved. analysis metformin-treated showed higher diversity. There differences derived some environmental bacteria Notably, Streptococcus salivarius more abundant group, suggesting it may be a potential probiotic. Discussion demonstrated findings offer new insights into pathogenesis provide avenues research.

Language: Английский

Citations

1
Microbiota Status and Endometrial Cancer: A Narrative Review About Possible Correlations in Affected Versus Healthy Patients DOI Creative Commons
Carmen Imma Aquino, Anthony Nicosia,

Arianna Ligori

et al.

Sci, Journal Year: 2024, Volume and Issue: 6(4), P. 75 - 75

Published: Nov. 7, 2024

(1) Background: Microbiota could be related to tumorigenesis through the persistence of an inflammatory state, also at endometrial level. Inflammation, in fact, is involved promotion genetic instability and a favorable microenvironment for tumor growth. One pathway disruption epithelial/mucosal barrier, with activation cytokines. The microbiota seem favor other patterns, such as insulin resistance increased adipose tissue. (2) Methods: online search this review was based on keywords “endometrial cancer” “microbiota” main scientific database. Our objective narrative up-to-date current literature gynecological microbiota; we analyze possible correlations known modifying promoting oncological factors (i.e., Body Mass Index- BMI, menopause, pH), particular attention vaginal uterine microorganisms respective development cancer comparison healthy women. (3) Results: Various species distributions bacteria induce alterations cell signaling cycle pathways, including those field. (4) Conclusions: In literature, different composition has been analyzed past years, their diversity actions correlate effects.

Language: Английский

Citations

1
Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites DOI Creative Commons

Damilola Christianah Lawore,

Smrutiti Jena, Alicia R. Berard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Abstract The vaginal microbiome’s role in risk, progression, and treatment of female cancers has been widely explored. Yet, there remains a need to develop methods understand the interaction microbiome factors with host cells characterize their potential therapeutic functions. To address this challenge, we developed systems biology framework term Pharmacobiome for pharmacology analysis. evaluates similarities between microbes microbial byproducts known drugs based on impact transcriptomic cellular signatures. Here, apply our characterization Anti-Gynecologic Cancer Vaginal Pharmacobiome. Using published multi-omics data from Partners PrEP clinical trial, constructed epithelial gene signatures associated each profiled microbe metabolite. We compared these microbiome-associated post-drug perturbation 35 FDA-approved anti-cancer Library Integrated Network-based Cellular Signatures database identify metabolites high statistical functional similarity drugs. found that Lactobacilli can regulate expression ways similar many Additionally, experimentally tested model prediction taurine, metabolite produced by L. crispatus, kills cancerous breast endometrial cancer cells. Our study shows is powerful characterizing generalizability other cancers, microbiomes, diseases.

Language: Английский

Citations

0
Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring? DOI Creative Commons
Cheryl S. Rosenfeld

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1628 - 1628

Published: July 23, 2024

Endocrine-disrupting chemicals (EDCs) have become so pervasive in our environment and daily lives that it is impossible to avoid contact with such compounds, including pregnant women seeking minimize exposures themselves their unborn children. Developmental exposure of humans rodent models bisphenol A (BPA) other EDCs linked increased anxiogenic behaviors, learning memory deficits, decreased socio-sexual behaviors. Prenatal BPA leads longstanding harmful effects on gut microbiota reductions beneficial bacteria, i.e., dysbiosis, microbial changes are host fecal metabolites, those involved carbohydrate metabolism synthesis, neurobehavioral alterations adulthood, particular, social cognitive deficits. Gut dysbiosis increasingly being recognized as a key driver myriad diseases, ranging from metabolic, cardiovascular, reproductive, disorders via the gut-microbiome-brain axis. Thus, might induce indirect physical mental health by acting microbiome-disrupting chemicals. Findings raise important question whether should consume probiotic supplement mitigate pernicious EDCs, especially BPA, offspring. Current studies investigating maternal supplementation women's offspring will be reviewed. Data inform potential application reverse unwittingly exposed these compounds striving give best start life.

Language: Английский

Citations

0
Вагинальный микробиом: общие положения и взаимосвязь с гинекологическим раком DOI Open Access

Матылевич О.П.,

Гришель А.С.,

Мавричев С.А.

et al.

Клиническая инфектология и паразитология, Journal Year: 2024, Volume and Issue: 13(3), P. 373 - 389

Published: Oct. 18, 2024

В последние годы взаимосвязь между микробиотой и ее влиянием на здоровье человека стала предметом множества научных исследований. Хотя сегодняшний день наиболее изучена микробиота желудочно-кишечного тракта, в последнее время интерес распространился другие виды. Нарушение качественного количественного состава микробиоты пищеварительного тракта ведет также к изменению урогенитального микробиоценоза. Сложные взаимодействия кишечника системным воспалением открывают новые аспекты понимании развития онкологических процессов женской репродуктивной системы. Кроме того, существует тесная связь уровнем циркулирующего эстрогена (эстроболомом), изменение которого может приводить развитию некоторых видов опухолей системы женщин. Необходимы дальнейшие исследования, чтобы лучше понимать раком, что, вероятно, улучшит диагностику лечение онкологической патологии. In recent years, the relationship between microbiota and its impact on human health has become subject of many scientific studies. Although gastrointestinal been most studied to date, interest recently spread other types microbiota. Violation qualitative quantitative composition also leads changes in urogenital microbiocenosis. Complex interactions intestinal systemic inflammation open up new aspects understanding development oncological processes female reproductive system. addition, there is a close level circulating estrogen (estrobolome), which can lead some tumors Further research needed better understand cancer, likely improve diagnosis treatment pathology.

Language: Русский

Citations

0
Advancements in Ovarian Cancer Research: Targeting DNA Repair Mechanisms and the Role of DNA Polymerase β Inhibitors DOI Open Access
Anutosh Patra, Abhishek Samanta, Anindita Chakraborty

et al.

Biosciences Biotechnology Research Asia, Journal Year: 2024, Volume and Issue: 21(4), P. 1439 - 1449

Published: Dec. 20, 2024

ABSTRACT: Background: Exposure to mutagens causes DNA damage, which, if not repaired properly, can lead diseases like cancer. Ovarian cancer is a major concern for women globally, including in India, as it often diagnosed at an advanced stage, making treatment more challenging. Recent research implicates repair proteins polymerase β (Pol β) development, emphasising the need understand these pathways targeted therapy. This study uses bibliometric analysis explore ovarian and pathways, providing insights future treatment. Materials Methods: Data from 37,539 articles related cancer, β, inhibitors were analysed Dimensions database. Publication distribution, national cooperation, leading authors, trends examined. Results: Variations publication distribution observed across journals, with notable contributions countries Germany, Canada, Netherlands. Prolific authors institutions identified, shedding light on global academic landscape. Co-occurrence revealed thematic clusters, pathophysiology, risk associations, therapeutic targets, genomic research. Conclusion: offers valuable into pathways. It highlights importance of targeting mechanisms therapy suggests opportunities collaboration personalised medicine. Identifying key directions aids advancing our understanding aiming improve patient outcomes.

Language: Английский

Citations

0