Journal of Pure and Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
18(3), P. 2047 - 2056
Published: Aug. 31, 2024
Understanding
and
harnessing
quorum
sensing
activity
identifying
bioactive
substances
produced
by
marine-derived
bacteria
are
essential
for
exploring
their
potential
applications
in
various
fields,
including
biotechnology,
pharmaceuticals,
environmental
management.
This
research
aims
to
investigate
the
quorum-sensing
activities
employed
these
characterize
compounds
they
produce,
unlock
therapeutic,
industrial,
ecological
potentials.
study
focuses
on
screening,
isolation
characterization
of
marine
from
Thoothukudi
Harbour
Beach,
India,
antibacterial
anti-quorum
respective
spent
media
against
biofilm
forming
pathogens.
Three
soil
samples
were
collected
processed
bacterial
isolation.
Seventeen
different
isolates
obtained
identified
after
prior
culture.
Antibacterial
was
evaluated
four
pathogenic
bacteria,
with
some
demonstrating
significant
inhibition.
Additionally,
inhibition
assays
conducted,
revealing
ability
certain
inhibit
formation
biofilms.
The
secondary
metabolites
present
ethyl
acetate
fraction
I.B
6
isolate
exhibiting
relatively
high
antibiofilm
properties
GC-MS.
Anti-quorum
also
investigated
using
swarming
assay
MIC
determined
accordingly
fraction.
Hence,
hold
producing
pharmaceutical
industrial
applications.
Finally,
positive
organism
is
subjected
16S
rRNA
sequencing
identification
found
be
Bacillus
thuringiensis.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4534 - 4534
Published: Sept. 24, 2024
Quorum
sensing
(QS)
is
a
bacterial
cell-to-cell
communication
mechanism
that
plays
an
essential
role
in
pathogenesis.
QS
governs
behavior
and
controls
biofilm
formation,
which
turn
contributes
to
antibiotic
resistance.
Therefore,
identifying
synthesizing
novel
compounds
overcome
inhibit
formation
are
essential.
Coumarins
important
plant-derived
natural
products
with
wide-ranging
bioactivities
extensive
applications,
including
antibacterial,
antifungal,
anticoagulant,
antioxidant,
anticancer,
anti-inflammatory
properties.
Additionally,
coumarins
capable
of
rewiring
inhibition,
leading
higher
susceptibility
antimicrobial
agents
less
this
review,
we
aim
provide
overview
formation.
This
review
also
discusses
the
synthesized
controlling
QS,
inhibiting
inducing
synergy
antibiotic–coumarin
combinations.
Hence,
emphasizes
potential
coumarin
act
as
antibacterial
demonstrates
their
ability
alleviate
Fermentation,
Journal Year:
2025,
Volume and Issue:
11(1), P. 36 - 36
Published: Jan. 17, 2025
The
article
reviews
the
literature
on
antimicrobial
peptides
(AMPs)
that
exhibit
unique
mechanisms,
such
as
broad-spectrum
activity,
low
development
of
resistance,
and
ability
to
modulate
immune
response
host
organism.
Information
is
provided
significant
potential
AMPs
in
fight
against
pathogens
threatening
human
health
food
safety.
Enrichment
diet
with
biologically
active
obtained
using
proteolytic
activity
lactic
acid
bacteria
(LAB)
proposed
a
simple,
accessible,
viable
alternative
antibiotics
does
not
have
harmful
side
effect.
review
briefly
covers
methods
for
obtaining
features
LAB
system
responsible
producing
bioactive
environment.
It
has
been
shown
various
strains
makes
it
possible
produce
high-quality
whey-based
beverages
different
directions
antagonistic
opportunistic
helps
optimize
gastrointestinal
microbiota.
assumed
drinks
can
reduce
dose
antimicrobials
combined
therapy
infectious
diseases
be
preventive
measure
contagion
spread
resistance.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 5, 2024
A
complex
structure
known
as
a
biofilm
is
formed
when
variety
of
bacterial
colonies
or
single
type
cell
in
group
sticks
to
surface.
The
extracellular
polymeric
compounds
that
encase
these
cells,
often
consisting
proteins,
eDNA,
and
polysaccharides,
exhibit
strong
antibiotic
resistance.
Concerns
about
the
pharmaceutical
industry,
public
health,
medical
fields
have
sparked
lot
interest,
resistance
unique
capacity
exhibited
by
biofilm-producing
bacteria,
which
increases
morbidity
death.
Biofilm
formation
complicated
process
controlled
several
variables.
Insights
into
processes
target
for
therapy
been
gained
from
multiple
attempts
dissect
process.
Targeting
pathogens
within
profitable
because
become
considerably
more
resistant
drugs
state.
Although
biofilm-mediated
infections
can
be
lessened
using
currently
available
medications,
there
has
focus
on
development
new
approaches,
such
bioinformatics
tools,
both
treating
preventing
production
biofilms.
Technologies
transcriptomics,
metabolomics,
nanotherapeutics
proteomics
are
also
used
develop
novel
anti-biofilm
agents.
These
techniques
help
identify
small
inhibit
important
regulators.
field
appropriate
control
strategies
avoid
expanding
quickly
this
spurred
study.
As
result,
current
article
addresses
our
knowledge
how
biofilms
form,
mechanisms
bacteria
resist
antibiotics,
cutting-edge
treatment
approaches
caused
Furthermore,
we
showcased
ongoing
research
utilizing
CRISPR/Cas9
gene
editing
system
combat
infections,
particularly
those
brought
lethal
drug-resistant
pathogens,
concluded
with
hypothesis
aspirations,
acknowledged
certain
limitations.
