COPD risk due to extreme temperature exposure: combining epidemiological evidence with pathophysiological mechanisms DOI

Jiayu Xu,

Guogang Xu,

Zehua Liu

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 116, P. 105731 - 105731

Published: May 1, 2025

Language: Английский

Pulmonary vascular disease, environmental pollution, and climate change DOI Creative Commons
Mona Lichtblau, Lena Reimann, Lucilla Piccari

et al.

Pulmonary Circulation, Journal Year: 2024, Volume and Issue: 14(2)

Published: April 1, 2024

Abstract Pollution and climate change constitute a combined, grave pervasive threat to humans the life‐support systems on which they depend. Evidence shows strong association between pollution cardiovascular respiratory diseases, pulmonary vascular disease (PVD) is no exception. An increasing number of studies has documented impact environmental extreme temperatures circulation right heart, severity outcomes patients with arterial hypertension chronic thromboembolic (PH), incidence embolism, prevalence diseases associated PH. Furthermore, downstream consequences impair health care systems' accessibility, could pose unique obstacles in case PVD patients, who require complex sophisticated network interventions. Patients, caretakers professionals should thus be included design policies aimed at adaptation mitigation current challenges, prevention further change. The purpose this review summarize available evidence concerning circulation, propose measures individual, healthcare community levels directed protecting PVD.

Language: Английский

Citations

5
TaoHeChengQi Decotion Alleviate Chronic renal failure via Regulation of PHD2/UCP1 and RIPK3/AKT/TGF-β Pathway DOI
Wei Liu, Cheng Hu,

Xiaojing Qian

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 141, P. 156548 - 156548

Published: March 13, 2025

Language: Английский

Citations

0
Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways DOI Creative Commons
Bowei Liu, Zhigang Peng, Hao Zhang

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 2, 2025

Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as hallmark cancer. It exerts context-dependent dual role in cancer initiation and progression, functioning tumor suppressor promoter. The complexity senescence arises from its mechanistic diversity, potential reversibility, heterogeneity. A key mediator these effects the senescence-associated secretory phenotype (SASP), repertoire bioactive molecules that influence microenvironment (TME) remodeling, modulate behavior, contribute to therapeutic resistance. Given intricate biology, presents both challenges opportunities for intervention. Strategies targeting pathways, including senescence-inducing therapies senolytic approaches, offer promising avenues treatment. This review provides comprehensive analysis regulatory mechanisms governing cellular tumors. We also discuss emerging strategies highlighting novel opportunities. deeper understanding processes essential developing precision improving clinical outcomes.

Language: Английский

Citations

0
COPD risk due to extreme temperature exposure: combining epidemiological evidence with pathophysiological mechanisms DOI

Jiayu Xu,

Guogang Xu,

Zehua Liu

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 116, P. 105731 - 105731

Published: May 1, 2025

Language: Английский

Citations

0