Effects of the umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis DOI Creative Commons
Zhijian Xiao, Xinying Wang, Li Cheng

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40490 - e40490

Published: Nov. 15, 2024

Background: This study aimed to evaluate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) in treatment knee osteoarthritis. Methods: PubMed, Web Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure and Wanfang databases were searched from inception March 31, 2024. RevMan 5.3 was used conduct meta-analyses final included studies. Results: Three randomized controlled studies conducted. Western Ontario McMaster Universities Osteoarthritis Index reduced UC-MSCs group compared that control (mean difference: ‐25.85; 95% confidence interval: −41.50, −10.20; P = .001). Knee Lysholm Score improved with 18.33; 12.89, 23.77; < .00001). Egger test showed .583, indicating no publication bias. Sensitivity analysis indicated results stable. Conclusion: Intra-articular injection function pain patients However, number small more are needed confirm this.

Language: Английский

Characterization of gene expression profiles in Alzheimer’s disease and osteoarthritis: A bioinformatics study DOI Creative Commons
Nian Liu,

Qian Deng,

Zining Peng

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0316708 - e0316708

Published: Feb. 7, 2025

Alzheimer's disease (AD) and Osteoarthritis (OA) have been shown to a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores potential common molecular mechanisms between AD OA through bioinformatics analysis, providing new insights for clinical treatment strategies. The OA-related datasets were downloaded from gene expression database GEO. analyzed obtain differentially expressed (DEG) AD, respectively. intersection these DEGs was identify (Co-DEGs). Subsequently, Co-DEGs enriched, protein-protein interaction network constructed core genes. genes validated separate dataset, their diagnostic value analyzed. In addition, using set enrichment analysis single-gene genome variation analysis. Analysis on chips patients revealed significant changes patterns. Notably, EFEMP2 TSPO, associated with inflammatory responses, showed lower levels patients, suggesting downregulation pathological backgrounds diseases. Additionally, GABARAPL1, which is crucial maturation autophagosomes, found be upregulated conditions. These findings suggest as biomarkers therapeutic targets. However, confirm effectiveness targets, more in-depth mechanistic studies needed future, particularly explore feasibility specific combating progression by regulating suggests that shares mechanisms. identification EFEMP2, TSPO key target highlights factors Further investigation into could lead candidate targets directions OA, offering promising avenues developing effective targeted interventions.

Language: Английский

Citations

0
Metabolic Dysregulation and Its Role in Postoperative Pain among Knee Osteoarthritis Patients DOI Open Access
Elena V. Tchetina, K. E. Glemba, G. A. Markova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3857 - 3857

Published: March 29, 2024

Knee osteoarthritis (KOA) is characterized by low-grade inflammation, loss of articular cartilage, subchondral bone remodeling, synovitis, osteophyte formation, and pain. Strong, continuous pain may indicate the need for joint replacement in patients with end-stage OA, although postoperative (POP) at least a two-month duration persists 10-40% OA. The inflammation observed tissues linked to caused production proinflammatory cytokines. Since biosynthesis cytokines requires energy, their supported extensive metabolic conversions carbohydrates fatty acids, which could lead disruption cellular homeostasis. Therefore, this study aimed investigate association between POP development disturbances energy conversions, focusing on carbohydrate acid metabolism. Peripheral blood samples were collected from 26 healthy subjects 50 OA before surgery. All implants validated orthopedic surgeons, demonstrated no inherent abnormalities cause other reasons than disease, such as malalignment, aseptic loosening, or excessive bleeding. Pain levels assessed surgery using visual analogue scale (VAS) neuropathic questionnaires, DN4 PainDETECT. Functional activity was evaluated Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). Three six months after surgery, indices according VAS 30 mm higher considered. Total RNA isolated whole analyzed quantitative real-time RT-PCR (qRT-PCR) expression genes related Protein examined measured an ELISA peripheral mononuclear cells (PBMCs). We used qRT-PCR because it most sensitive reliable method gene analysis, while confirm our results. Among cohort, 17 who reported significantly (p < 0.05) expressions PKM2, LDH, SDH, UCP2, CPT1A, ACLY compared pain-free KOA. Receiver-operating characteristic (ROC) curve analyses confirmed these post-arthroplasty. A principle component analysis identified prognostic values ACLY, AMPK, SDHB, Caspase 3, IL-1β subjects. These findings suggest that metabolism, PBMCs KOA arthroplasty, contribute development. An understanding processes provide insights into pathogenesis Additionally, can be clinical setting predict arthroplasty.

Language: Английский

Citations

3
Effects of physical and psychological multimorbidity on the risk of dementia: multinational prospective cohorts and a meta-analysis DOI Creative Commons
Min Du, Min Liu, Jue Liu

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 27, 2024

Language: Английский

Citations

3
Extracellular vesicle-packed microRNAs profiling in Alzheimer’s disease: The molecular intermediary between pathology and diagnosis DOI

S. H. Arif,

Talal Jamil Qazi, Zhenzhen Quan

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102614 - 102614

Published: Dec. 1, 2024

Language: Английский

Citations

2
Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity DOI Creative Commons
Anyi Wang,

He‐Ying Hu,

Liangyu Huang

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 19, 2024

As a currently incurable but preventable disease, the prevention and early diagnosis of Alzheimer's disease (AD) has long been research hotspot. Amyloid deposition shown to be major pathological feature AD. Notably, not all people with amyloid-beta (Aβ) pathology will have significant cognitive declines eventually develop Therefore, aim this study was explore risk factors for decline in Aβ-positive participants.

Language: Английский

Citations

1
Pathophysiology of Alzheimer’s disease: an insight into the genetic factors, hypotheses, redox imbalance, and antioxidant intervention DOI
Teslim Simisola Abdulkadir, Joseph Olusegun Ayo

Comparative Clinical Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Citations

1
Investigating the potential neuroprotective benefits of taurine and Dihydrotestosterone and Hydroxyprogesterone levels in SH-SY5Y cells DOI Creative Commons
Hailah M. Almohaimeed, Amany I. Almars,

Fayez Alsulaimani

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: May 29, 2024

Background Taurine, an amino acid abundantly found in the brain and other tissues, has potential neuroprotective properties. Alzheimer’s disease (AD) is a commonly occurring type of dementia, which becomes more prevalent as people age. This experiment aimed to assess effects taurine on SH-SY5Y cells by examining its impact Dihydrotestosterone (DHT), Dihydroprogesterone (DHP), well expression miRNA-21 miRNA-181. Methods The various concentrations (0.25, 0.75 mg/mL), LPS (0.1, 12 mg/mL) cell line were assessed using MTT assay. levels DHT DHP quantified ELISA kit. Additionally, miRNA-181 genes examined through Real-Time PCR analysis. Results results assay showed that treatment with at 0.25, mg/mL reduces toxicity cells. indicated concentration significantly elevated hormones compared untreated group ( p &lt; 0.01). IL-1β IL-6 decreased under influence after (p Gene analysis revealed increasing resulted heightened miRNA-21, most significant increase observed 0.001). Conclusion Our study findings can be enhanced taurine. Consequently, exploring targeting taurine, miRNA-181, or considering hormone therapy may offer therapeutic approaches for treating AD alleviating severe symptoms. Nonetheless, order fully comprehend precise mechanisms involved, additional research required.

Language: Английский

Citations

0
Mediating Effect of Cognitive Reserve in the Relationship Between Physical Activity and Cognitive Function in Community-Dwelling Older Adults DOI

Hao Ran Zhang,

Jia Wu,

Lecong Wang

et al.

Experimental Aging Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Oct. 6, 2024

The aim of this study was to investigate the mediating effect cognitive reserve (CR) on association between physical activity and function in community-dwelling older adults. A total 495 adults were included cross-sectional study. CR, function, activity, potential confounders assessed. Regression bootstrap analyses used explore role CR function. Compared with low moderate high had significantly better global (βMoCA scores = 1.22, 95% CI 0.41 ~ 2.04) visual spatial (βCDT 0.52, 0.11 0.94) after adjustment for confounders. mediated an indirect (βMoCAscores -0.29, -0.56 -0.09) (βCDTscores -0.14, -0.28 -0.05) adjusting confounders, 23.8% 26.7% as percentage mediation, respectively. These findings suggest that could be effective increasing preserving or improving

Language: Английский

Citations

0
Effects of the umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis DOI Creative Commons
Zhijian Xiao, Xinying Wang, Li Cheng

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(46), P. e40490 - e40490

Published: Nov. 15, 2024

Background: This study aimed to evaluate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) in treatment knee osteoarthritis. Methods: PubMed, Web Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure and Wanfang databases were searched from inception March 31, 2024. RevMan 5.3 was used conduct meta-analyses final included studies. Results: Three randomized controlled studies conducted. Western Ontario McMaster Universities Osteoarthritis Index reduced UC-MSCs group compared that control (mean difference: ‐25.85; 95% confidence interval: −41.50, −10.20; P = .001). Knee Lysholm Score improved with 18.33; 12.89, 23.77; < .00001). Egger test showed .583, indicating no publication bias. Sensitivity analysis indicated results stable. Conclusion: Intra-articular injection function pain patients However, number small more are needed confirm this.

Language: Английский

Citations

0