Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
136, P. 111234 - 111234
Published: Dec. 24, 2024
β-Caryophyllene
(BCP)
is
a
naturally
occurring
sesquiterpene
found
in
numerous
plant
species,
including
Cannabis
sativa.
BCP
has
shown
high
safety
profile
and
wide
range
of
biological
functions,
beneficial
effects
neurodegenerative
inflammatory
diseases.
Here,
we
used
behavioral,
pharmacological,
in-silico
docking
analyses
to
investigate
the
mechanism
action
Fragile
X
Syndrome
(FXS),
most
common
inherited
cause
Autism
Spectrum
Disorder
(ASD)
intellectual
disability.
To
this
aim,
recently
validated
Fmr1-
Pharmacognosy Journal,
Journal Year:
2025,
Volume and Issue:
16(6), P. 1252 - 1258
Published: Jan. 1, 2025
This
investigation
aimed
to
evaluate
the
antidepressant,
anxiolytic,
and
antioxidant
effects
of
Piper
aduncum
essential
oil
from
northern
Peru.
The
oils
were
obtained
through
hydro-distillation
using
a
modified
Clevenger-type
apparatus.
chromatography-mass
spectrometry
(GC-MS)
was
used
assess
chemical
composition.
Behavioral
assays
in
mice
antidepressant
anxiolytic
effects.
In
addition,
capacity
performed
DPPH,
ABTS,
FRAP
assays.
GC-MS
analysis
revealed
that
linalool
(29.16%),
bicyclogermacrene
(13.32%),
nerolidol
(12.38%),
β-caryophyllene
(10.76%)
principal
components.
results
demonstrated
significant
comparable
fluoxetine
diazepam,
with
statistical
differences
between
all
groups
(p<0.005).
IC50
values
for
5.9±0.08,
0.20±0.06,
109.5±1.3,
respectively.
Consequently,
exhibits
anxiolytic-like
modest
properties
compared
controls.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
209, P. 107466 - 107466
Published: Oct. 15, 2024
Myocardial
ischemia
causes
extensive
damage,
further
exacerbated
by
reperfusion,
a
phenomenon
called
myocardial
ischemia/reperfusion
injury
(MIRI).
Nowadays,
the
pathological
mechanisms
of
MIRI
have
received
attention.
Oxidative
stress,
multiple
programmed
cell
deaths,
inflammation
and
others
are
all
essential
contributing
to
MIRI.
Mitochondria
energy
supply
centers
cells.
Numerous
studies
found
that
abnormal
mitochondrial
function
is
an
"culprit"
MIRI,
mitophagy
mediated
phosphatase
tensin
homolog
(PTEN)-induced
kinase
1
(PINK1)/Parkin
signaling
pathway
integral
part
maintaining
function.
Therefore,
exploring
association
between
PINK1/Parkin
pathway-mediated
crucial.
This
review
will
mainly
summarize
crucial
role
in
MIR-induced
several
various
potential
interventions
affect
mitophagy,
thus
ameliorating
Plants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 587 - 587
Published: Feb. 14, 2025
This
study
investigated
the
chemical
composition
and
potential
antibacterial
activity
of
essential
oils
from
propolis
Melipona
quadrifasciata
(MQP)
in
samples
collected
cities
Paranaguá
Guaratuba,
Paraná,
Brazil,
during
summer
winter.
The
was
analyzed
by
GC-MS,
their
minimum
inhibitory
concentration
(MIC)
determined
against
standard
ATCC
strains
some
clinical
isolates
(Escherichia
coli
06
Staphylococcus
aureus
10).
oils'
MICs
were
using
microdilution
96-well
plates
showed
no
significant
(MIC
≥
1024
μg/mL)
when
used
alone.
However,
enhanced
action
norfloxacin,
gentamicin,
ampicillin,
especially
S.
10.
analysis
identified
68
compounds,
with
β-bisabolene
β-caryophyllene
as
predominant
constituents.
Subsequently,
antibiotic-enhancing
evaluated.
MQP
varied
according
to
seasonality
location,
influenced
microclimates
cities.
results
highlight
importance
enhancing
antibiotic
activity,
particularly
Gram-positive
bacteria,
despite
lack
standalone
activity.
ABSTRACT
Male
sexual
dysfunction,
characterised
by
reduced
libido,
ejaculatory
issues
and
erectile
often
results
from
oxidative
stress
enzymatic
imbalance,
notably
involving
phosphodiesterase
type
5
(PDE5)
nitric
oxide
synthase
(NOS).
This
study
explores
the
therapeutic
potential
of
β‐caryophyllene
(β‐CBP),
a
sesquiterpene
with
antioxidant
anti‐inflammatory
properties,
in
mitigating
paroxetine‐induced
dysfunction
rats.
Wistar
rats
were
divided
into
nine
treatment
groups:
control,
paroxetine
(20
mg/kg/day),
sildenafil
β‐CBP
(10
mg/kg),
sildenafil.
Sexual
behavioural
assays
evaluated,
along
markers,
including
superoxide
dismutase
(SOD)
catalase
(CAT)
activity
penile
tissue,
assessed
using
spectrophotometric
analysis.
CB2
receptor
expression
was
significantly
increased
β‐CBP‐treated
groups,
suggesting
enhanced
cannabinoid
receptor‐mediated
signalling,
which
may
be
linked
to
improved
function.
The
effects
dose‐dependent,
20
mg/kg
group
displaying
most
significant
improvements.
Additionally,
restored
enzyme
activities,
SOD,
CAT
glutathione
(GSH)
levels
effectively
reducing
stress.
shows
promise
as
agent
for
male
enhancing
antioxidative
capacity
modulating
balance.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2530 - 2530
Published: March 12, 2025
The
guava
tree
(Psidium
guajava
L.)
is
a
tropical
plant
from
the
Myrtaceae
family.
Leaf
extracts
this
have
been
used
in
traditional
medicine
to
treat
gastrointestinal
disorders
and
exhibit
several
functional
activities
that
benefit
human
health.
Different
varieties
of
trees
produce
fruits
colors
ranging
white
red
present
characteristic
metabolic
profile
both
their
leaves
fruits.
This
study
presents
metabolomic
characterization
two
varieties:
Caxcana
cultivar
with
yellow
S-56
accession
pink
Metabolite
profiling
was
conducted
using
Gas
Chromatography–Mass
Spectrometry
(GC–MS)
on
methanol
extracts,
followed
by
multivariate
statistical
analysis,
including
Principal
Component
Analysis
(PCA),
heat
map
visualization
compound
concentrations
varieties.
results
identified
β-caryophyllene
as
major
secondary
metabolite
varieties,
relative
abundance
16.46%
variety
23.06%
cultivar.
Furthermore,
silico
analyses,
such
network
pharmacology
molecular
docking,
revealed
key
interactions
proteins
CB2,
PPARα,
BAX,
BCL2,
AKT1,
suggesting
potential
therapeutic
relevance.
These
findings
highlight
pharmacological
leaf
metabolites
natural
product
chemistry
drug
discovery.
Türkiye Tarımsal Araştırmalar Dergisi,
Journal Year:
2025,
Volume and Issue:
12(1), P. 63 - 71
Published: March 28, 2025
This
study,
the
chemical
composition
of
pine
resin
collected
from
three
different
locations
(Kaburgediği,
Karabucak
and
Mavisilifke)
Mersin
province
in
Mediterranean
Region
Türkiye
was
investigated
using
headspace/GC-MS
direct
injection/GC-MS
techniques.
A
commercial
essential
oil
used
as
a
control
sample
study.
The
analysis
focused
on
key
volatile
compounds,
including
α-pinene,
delta-3-carene,
camphene,
DL-limonene
(mixture
D-
L-form),
caryophyllene.
method
more
effective
for
detecting
compounds
with
higher
volatility,
such
which
abundant
(66.12%
headspace
vs.
53.13%
injection).
On
other
hand,
provided
sensitivity
less
caryophyllene
(4.82%
injection
0.67%
Kaburgediği).
most
significant
difference
between
methods
observed
detection
DL-limonene,
showed
concentrations
(3.76%
compared
to
(1.51%).
suggests
that
is
better
quantifying
lower
while
capturing
overall
aroma
profile,
especially
compounds.
highlights
efficiency
based
compound's
volatility.
Therefore,
choosing
right
depends
specific
interest
their
volatility
characteristics.
These
findings
highlight
unique
profiles
each
resin,
shaped
by
both
species
analytical
used,
implications
aromatic
potential
pharmacological
properties.
