Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 6, 2025

Language: Английский

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Macrophage Polarization: Learning to Manage It 3.0

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 311 - 311

Published: Jan. 1, 2025

Macrophages are cells of the innate immune system with very peculiar characteristics, so plastic that they respond rapidly to environmental changes by assuming different and sometimes contrasting functions, such as initiating a physiological inflammatory response or interrupting it repairing damaged tissues [...]

Language: Английский

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Brain macrophage senescence in glioma

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 104-105, P. 46 - 60

Published: Aug. 3, 2024

Language: Английский

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Mannose modified graphene oxide drug-delivery system targets cancer stem cells and tumor-associated macrophages to promote immunotherapeutic efficacy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114710 - 114710

Published: April 17, 2025

Language: Английский

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One-carbon metabolic reprogramming and its relationship with tumor-infiltrating lymphocytes and Immune checkpoint in Pancreatic cancer

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

BACKGROUND The role of oncogene-driven metabolic reprogramming in pancreatic cancer (PC) remains unclear. This study explored the interplay between one-carbon metabolism (OCM), driver genes, and tumor microenvironment (TME) PC. METHODS Targeted metabolomics analyzed 136 PC serum samples. Transcriptomic OCM gene data from 930 patients were obtained public databases. Non-negative matrix factorization (NMF) clustering classified subtypes. Single-cell analysis deciphered features TME. Immunohistochemistry assessed MTHFD1L expression, cancer-associated fibroblast (CAF) markers (FAP, α-SMA), immune cells (CD8+/Foxp3+ TILs, CD206+ TAMs), PD-1/PD-L1 138 tissue RESULTS identified altered amino acid (73 metabolites). NMF stratified into C1/C2 subtypes with distinct prognoses TME characteristics (p<0.05). revealed dysregulation cells, macrophages, fibroblasts. emerged as a core reprogramming, correlating poor overall survival (OS, p=0.005) disease-free (DFS, p=0.006). High expression was linked to lymph node metastasis positively associated FAP CAFs (p<0.05), TAMs (p<0.001), Foxp3+ TIL infiltration Multivariate confirmed an independent prognostic factor (p=0.022). CONCLUSION OCM is hallmark drives oncogenic influences prognosis by modulating CAFs, TAMs, Tregs. Targeting or may offer therapeutic potential.

Language: Английский

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ALG3 predicts poor prognosis and increases resistance to anti-PD-1 therapy through modulating PD-L1 N-link glycosylation in TNBC

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112875 - 112875

Published: Aug. 9, 2024

Language: Английский

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A novel semi-quantitative scoring method for CD8+ tumor-infiltrating lymphocytes based on infiltration sites in gastric cancer

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(12), P. 5965 - 5986

Published: Jan. 1, 2024

No established method currently exists for evaluating tumor-infiltrating lymphocytes (TILs) in gastric cancer (GC), and their clinical significance based on infiltration site GC remains unclear. In this study, we developed a to evaluate TILs according as prognostic marker GC. We retrospectively analyzed 103 patients with advanced who underwent curative resection. located at the invasive margin (TIL

Language: Английский

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