Epidemiology and molecular evolution of GI.1 sapovirus in the recent era DOI
Sheikh Ariful Hoque,

Yuki Akari,

Pattara Khamrin

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(9)

Published: Sept. 1, 2024

Abstract Sapovirus (SaV) infection is increasing worldwide. Herein, we provided evidence of a significant increase in SaV Japan during 2010–2022, primarily due to the considerable ( p = 0.0003) rise GI.1 genotype. Furthermore, found that all major and minor outbreaks Japan, including largest outbreak 2021–2022, were caused by Therefore, get insight into underlying molecular mechanism behind this rising trend type, selected 15 strains for complete genome analysis through next‐generation sequencing. Phylogenetically, our remained clustered different branches lineages I II among We showed amino acid (aa) substitutions open reading frames (ORFs) these strains. Importantly, have demonstrated involved 2021–2022 belonged lineage possessed third ORF. identified some unique aa mutations NS1 NS6‐NS7 regions are thought be associated with viral pathogenicity, cell tropism, epidemiological competence. Thus, addition enriching database SaV's sequences, study provides insights its important mutations.

Language: Английский

Epidemiology and molecular evolution of GI.1 sapovirus in the recent era DOI
Sheikh Ariful Hoque,

Yuki Akari,

Pattara Khamrin

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(9)

Published: Sept. 1, 2024

Abstract Sapovirus (SaV) infection is increasing worldwide. Herein, we provided evidence of a significant increase in SaV Japan during 2010–2022, primarily due to the considerable ( p = 0.0003) rise GI.1 genotype. Furthermore, found that all major and minor outbreaks Japan, including largest outbreak 2021–2022, were caused by Therefore, get insight into underlying molecular mechanism behind this rising trend type, selected 15 strains for complete genome analysis through next‐generation sequencing. Phylogenetically, our remained clustered different branches lineages I II among We showed amino acid (aa) substitutions open reading frames (ORFs) these strains. Importantly, have demonstrated involved 2021–2022 belonged lineage possessed third ORF. identified some unique aa mutations NS1 NS6‐NS7 regions are thought be associated with viral pathogenicity, cell tropism, epidemiological competence. Thus, addition enriching database SaV's sequences, study provides insights its important mutations.

Language: Английский

Citations

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