Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionuclide Therapy for Glioblastoma DOI Open Access
Siddharth Shah, Brandon Lucke‐Wold

Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2892 - 2892

Published: Aug. 20, 2024

Glioblastoma (GBM) is a highly aggressive, invasive, and growth factor-independent grade IV glioma. Survival following the diagnosis generally poor, with median survival of approximately 15 months, it considered most aggressive lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, radiation therapy only delay progression, death inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due subpopulation stem that invasive capable rapid regrowth. This literature review. The systematic retrieval information was performed PubMed, Embase, Google Scholar. Specified keywords were used in PubMed articles retrieved published peer-reviewed scientific journals associated brain GBM cancer sodium iodide symporter (NIS). Additionally, words 'radionuclide OR mesenchyma, radioiodine iodine-131 molecular imaging gene translational targeted theranostic virus solid tumor combined pituitary plasmid AND glioblastoma GB glioma' also appropriate databases A total 68,244 found this search Mesenchymal Stem Cell Sodium Iodide Symporter GBM. These till 2024. To study recent advances, filter added include from 2014 2024, duplicates removed, not related title excluded. came out be 78 articles. From these, nine seven selected after removal keyword mismatched Appropriate studies isolated, important each them understood entered into database which article. As result their natural capacity identify malignancies, MSCs employed as vehicles. Because may transplanted using several methods, they have been proposed ideal vehicles for NIS transfer. delivery vector anticancer drugs many models move precisely malignancies. Also, by directly injecting radiolabeled malignant tumors, therapeutic dosage beta deposited, benefit would localize spread surrounding healthy tissues. non-invasive imaging-based detection presents an alternate means monitor diagnose evaluate recurrence. specific variety human thyroid diseases functions iodine cell. In years, increasing number reported tumors vectors therapy. Gene nuclear medicine provide new direction. all preclinical reviewed, image-guided cell led greater benefits and, therefore, has potential translated techniques treatment trials.

Language: Английский

Exosomes as targeted diagnostic biomarkers: Recent studies and trends DOI

Aida Abbasi Marjani,

Nader D. Nader, Ayuob Aghanejad

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122985 - 122985

Published: Aug. 14, 2024

Language: Английский

Citations

10
Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery DOI
Ongun Mehmet Saka, Devrim Demir Dora, Güneş Kibar

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 368, P. 123499 - 123499

Published: Feb. 22, 2025

Language: Английский

Citations

1
Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionucleotide Therapy for Glioblastoma DOI Open Access
Siddharth Shah, Brandon Lucke‐Wold

Published: July 9, 2024

Background: Glioblastoma (GBM) is a highly aggressive, invasive, and growth-factor-independent grade IV glioma. Survival following the diagnosis generally poor, with median survival of approximately 15 months, it considered most aggressive lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, radiation therapy only delay progression, death inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due subpopulation stem that invasive capable rapid regrowth. Methods: Systematic retrieval information was performed PubMed. Specified keywords were used in PubMed articles published peer-reviewed scientific journals associated brain GBM cancer, sodium iodide symporter (NIS). Additionally, words 'radionuclide therapy', 'radioiodine', 'iodine-131', 'molecular imaging', 'gene 'translational imaging' used. Other such as ‘glioblastoma', 'targeted', 'theranostic', 'symporter', 'virus', 'solid tumor', 'combined 'pituitary', or 'plasmid' also appropriate literature databases search engines. 19 found this Mesenchymal Stem Cell Sodium Iodide Symporter GBM. \ These from years 2000 2024. Appropriate studies isolated, important each them understood entered into database which article. Results: For long they express functional NIS, mesenchymal systemically repress T B cells; however, after that, largely replaced by generated embryonic functionally competent. As result their natural capacity identify malignancies, MSC employed tumor vehicles. Because MSCs may be transplanted several methods, have been proposed ideal vehicles for NIS gene transfer. Conclusion: Non-invasive imaging-based detection presents an alternate means monitor diagnose evaluate recurrence. The iodine specific variety human thyroid disease functions move cell. In recent years, increasing number related reported tumors therapeutic vectors imaging therapy. Gene nuclear medicine provide new direction.

Language: Английский

Citations

3
Image-Guided Mesenchymal Stem Cell Sodium Iodide Symporter (NIS) Radionuclide Therapy for Glioblastoma DOI Open Access
Siddharth Shah, Brandon Lucke‐Wold

Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2892 - 2892

Published: Aug. 20, 2024

Glioblastoma (GBM) is a highly aggressive, invasive, and growth factor-independent grade IV glioma. Survival following the diagnosis generally poor, with median survival of approximately 15 months, it considered most aggressive lethal central nervous system tumor. Conventional treatments based on surgery, chemotherapy, radiation therapy only delay progression, death inevitable. Malignant glioma cells are resistant to traditional therapies, potentially due subpopulation stem that invasive capable rapid regrowth. This literature review. The systematic retrieval information was performed PubMed, Embase, Google Scholar. Specified keywords were used in PubMed articles retrieved published peer-reviewed scientific journals associated brain GBM cancer sodium iodide symporter (NIS). Additionally, words 'radionuclide OR mesenchyma, radioiodine iodine-131 molecular imaging gene translational targeted theranostic virus solid tumor combined pituitary plasmid AND glioblastoma GB glioma' also appropriate databases A total 68,244 found this search Mesenchymal Stem Cell Sodium Iodide Symporter GBM. These till 2024. To study recent advances, filter added include from 2014 2024, duplicates removed, not related title excluded. came out be 78 articles. From these, nine seven selected after removal keyword mismatched Appropriate studies isolated, important each them understood entered into database which article. As result their natural capacity identify malignancies, MSCs employed as vehicles. Because may transplanted using several methods, they have been proposed ideal vehicles for NIS transfer. delivery vector anticancer drugs many models move precisely malignancies. Also, by directly injecting radiolabeled malignant tumors, therapeutic dosage beta deposited, benefit would localize spread surrounding healthy tissues. non-invasive imaging-based detection presents an alternate means monitor diagnose evaluate recurrence. specific variety human thyroid diseases functions iodine cell. In years, increasing number reported tumors vectors therapy. Gene nuclear medicine provide new direction. all preclinical reviewed, image-guided cell led greater benefits and, therefore, has potential translated techniques treatment trials.

Language: Английский

Citations

1