Operativnaâ hirurgiâ i kliničeskaâ anatomiâ (Pirogovskij naučnyj žurnal), Journal Year: 2024, Volume and Issue: 8(4), P. 18 - 18
Published: Jan. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 215 - 215
Published: Feb. 7, 2025
Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.
Language: Английский
Citations
5
Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 133 - 133
Published: March 13, 2025
Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.
Language: Английский
Citations
3
Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88
Published: Jan. 23, 2025
There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive
Language: Английский
Citations
2
Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693
Published: Oct. 25, 2024
Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.
Language: Английский
Citations
10
Crystals, Journal Year: 2025, Volume and Issue: 15(3), P. 211 - 211
Published: Feb. 23, 2025
Hydrogels represent a versatile class of materials with remarkable potential as three-dimensional matrices for nanoparticle integration. This study explores the mechanism silver formation within polyacrylamide–alginate hybrid hydrogel, employing controlled reduction–oxidation reaction between nitrate (AgNO3) and sodium borohydride (NaBH4) across temperature gradient (5–70 °C). Characterization techniques, including Raman, infrared, UV-Vis spectroscopies, X-ray diffraction, scanning electron microscopy, were employed to analyze structural optical properties nanoparticles hydrogel. The results show that, rose, numbers decreased, while their size increased. Consistently octahedral in shape averaging 100–120 nm, these revealed temperature-dependent growth pattern, rare larger crystals emerging more frequently at higher temperatures. findings highlight hydrogels effective incorporation metal nanoparticles, paving way applications drug delivery, biosensing, antimicrobial treatments.
Language: Английский
Citations
1
Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 29, 2024
The most prevalent and harmful injuries are burns, which still a major global health problem. Burn can cause issues because they boost the inflammatory metabolic response, organ malfunction systemic failure. On other hand, burn wound infection creates an environment that is conducive to growth of bacteria might put patient at risk for sepsis. In addition, scarring unavoidable, this results in patients having functional cosmetic issues. Wound healing amazing phenomenon with complex mechanism deals different types cells biomolecules. Cell therapy using stem one challenging treatment methods accelerates wounds. Since 2000, use mesenchymal (MSCs) regenerative medicine has increased. They be extracted from various tissues, such as bone marrow, fat, umbilical cord, amniotic membrane. According studies, cell wounds increases angiogenesis, anti-inflammatory properties, slows progression fibrosis, excellent ability differentiate regenerate damaged tissue. Figuring out main preclinical clinical problems stop people MSCs then suggesting right ways improve could help show benefits move cell-based forward. This review's objective was assess therapy's contribution promotion healing.
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135410 - 135410
Published: Sept. 6, 2024
Language: Английский
Citations
4
Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 245 - 245
Published: March 26, 2025
Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.
Language: Английский
Citations
0
IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1439(1), P. 012034 - 012034
Published: Jan. 1, 2025
Abstract This research aims to develop an optimal hydrogel formula using Design Expert 13.0 and the Simplex Lattice (SLD) method. The combines Centella asiatica Moringa oleifera extracts with carbopol 940 as a gelling agent triethanolamine (TEA) alkalizer. Hydrogels were chosen due their ease of use, cooling effect, superior biocompatibility compared other topical formulations like ointments or creams. study focused on optimizing meet Indonesian National Standards (SNI). After eight trials SLD method, physical evaluations conducted, including organoleptic tests, pH measurements, spreadability, viscosity tests. contained 0.6% Carbopol 0.4% TEA, validated three replications. exhibited deep green color, distinctive extract aroma, thick texture, meeting SNI standards average 7.1±0.29, spreadability 5.7±0.21 cm, 20,080±0.35 cPs. Stability tests confirmed its quality after cycling centrifugal evaluations. promotes sustainable eco-friendly practices by utilizing natural extracts, reducing reliance synthetic chemicals, contributing environmentally conscious drug innovations. development such hydrogels aligns sustainability goals, offering biodegradable safe that minimize environmental impact.
Language: Английский
Citations
0