Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

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Influence of gut and lung dysbiosis on lung cancer progression and their modulation as promising therapeutic targets: a comprehensive review

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 24, 2024

Abstract Lung cancer (LC) continues to pose the highest mortality and exhibits a common prevalence among all types of cancer. The genetic interaction between human eukaryotes microbial cells plays vital role in orchestrating every physiological activity host. dynamic crosstalk gut lung microbiomes gut–lung axis communication network has been widely accepted as promising factors influencing LC progression. advent 16s rDNA sequencing technique opened new horizons for elucidating microbiome its potential pathophysiological other infectious diseases using molecular approach. Numerous studies have reported direct involvement host tumorigenesis processes their impact on current treatment strategies such radiotherapy, chemotherapy, or immunotherapy. metabolomic cross‐interaction, microbiome‐dependent immune modulation, close association microbiota composition outcomes strongly suggest that designing microbiome‐based investigating molecules targeting holobiome could offer alternatives develop effective therapeutic principles treatment. This review aims highlight progression possibility manipulating altered ecology targets.

Language: Английский

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The Influence of the Gut Microbiota on Host Health: A Focus on the Gut–Lung Axis and Therapeutic Approaches

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1279 - 1279

Published: Oct. 9, 2024

The human gut microbiota is a complex ecosystem harboring thousands of microbial strains that play crucial role in maintaining the overall well-being its host. composition varies with age from infancy to adulthood and influenced by dietary habits, environment, genetic disposition. Recent advances culture-independent techniques nucleic acid sequencing have improved our understanding diversity microbiota. species present release short-chain fatty acids (SCFAs), which anti-inflammatory properties. also plays substantial modulating host's immune system, promoting tolerance, homeostasis. impact on health host quite evident, as dysbiosis has been linked various diseases, including metabolic disorders, autoimmune allergies, inflammatory bowel diseases. bidirectional communication respiratory creating gut-lung axis, associated different Therapeutic approaches targeting microbiota, such probiotics, prebiotics, interventions, fecal transplantation (FMT), aim restore balance promote growth beneficial gut. Nonetheless, gaining knowledge interactions between necessary develop personalized medicine microbiota-based therapies for conditions. This review summarizes studies related axis particular emphasis Future research directions are discussed.

Language: Английский

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Intranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection

Antiviral Research, Journal Year: 2025, Volume and Issue: 234, P. 106076 - 106076

Published: Jan. 2, 2025

Language: Английский

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Recent insights and advances in gut microbiota's influence on host antiviral immunity

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

A diverse array of microbial organisms colonizes the human body, collectively known as symbiotic communities. Among various pathogen infections that hosts encounter, viral represent one most significant public health challenges worldwide. The gut microbiota is considered an important biological barrier against and may serve a promising target for adjuvant antiviral therapy. However, potential impact on infection remains relatively understudied. In this review, we discuss specific regulatory mechanisms in immunity, highlighting recent advances how regulate host immune response, produce immune-related molecules, enhance host's defense viruses. Finally, also oral probiotics.

Language: Английский

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Lung Microbiome in Autoimmune-Associated Interstitial Lung Disease

Rheumatic Disease Clinics of North America, Journal Year: 2025, Volume and Issue: 51(2), P. 201 - 212

Published: Feb. 28, 2025

Language: Английский

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Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

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Clinical characteristics and risk factors of late-stage lung adenocarcinoma patients with bacterial pulmonary infection and its relationship with cellular immune function

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

To research the clinical characteristics, risk factors, correlation between bacterial pulmonary infection and immune function of advanced lung adenocarcinoma patients complicated with infection. 334 stage III IV admitted to first affiliated hospital Zhengzhou University from January 2020 March 2023 were selected divided into an group (n = 240) a control (n= 72) according whether The characteristics analyzed. microbiota human T lymphocyte subsets (CD3+, CD4+, CD8+) detected. Multivariate logistic regression analysis was performed explore factors for in patients. Among patients, 264 cases infection, 70 had no In total, 544 pathogenic bacteria isolated Of these, 170 strains (31.25%) Gram-negative bacilli, 162 (29.78%) Gram-positive cocci, 27 (4.96%) bacilli. There statistically significant differences age, smoking, combined diseases, TNM staging, CD3+ cell percentage, CD4+ percentage two groups (P < 0.05). revealed bronchiectasis, diabetes independent leading late-stage those on checkpoint inhibitors, has higher number cells CD4+/CD8+ ratio than Smoking, are adenocarcinoma. effect inhibitor treatment is more pronounced Gram positive bacteria.

Language: Английский

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Enhancing the Nutraceutical and Nutritional Features of Wheat Germ to Reduce Atopic Asthma Symptoms in Children

Journal of Asthma, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: May 15, 2025

The rise in childhood asthma has increased interest nutraceutical treatment options such as specific nutritional supplements, medical treatments may not always produce the desired results. Despite treatment, between 30 and 50 percent of children with do attain adequate control. For first time, effects adding fermented wheat germ to daily diet atopic on respiratory function-related disease symptoms, serum IgE, eosinophil levels were studied. study comprised 52 patients (control group n = 26, experimental 26) aged 12 18 years a clear diagnosis asthma. consumed 100 g bread 5% every day for three months, while control standard bread. groups assessed at baseline end each month spirometry (FVC, FEV1, PEF), IgE measurements, application Asthma Control Test (ACT) scale. There was no significant difference terms any measurement. had increases PEF (p < 0.05), FVC, 0.001) compared monthly measurements. Both showed statistically improvements ACT FEV1 0.001). Nonetheless, time-dependent > 0.05). Although inclusion asthmatic children's diets been shown improve levels, these findings require further investigation.

Language: Английский

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Reactivation of Latent Tuberculosis Following COVID-19 and Epstein-Barr Virus Coinfection: A Case Report

Pathogens, Journal Year: 2025, Volume and Issue: 14(5), P. 488 - 488

Published: May 16, 2025

Background: This case is unique in demonstrating the reactivation of latent tuberculosis (TB) following co-infection with SARS-CoV-2 and Epstein–Barr virus (EBV) an otherwise healthy young adult. It highlights a rare clinical scenario which viral immune dysregulation likely facilitated TB progression. To date, few reports have explored complex interplay between COVID-19, EBV reactivation, single patient, particularly isolated extrapulmonary involvement. Case Presentation: A 24-year-old woman presented persistent low-grade fever, fatigue, night sweats, unintentional weight loss, progressive cervical supraclavicular lymphadenopathy. These symptoms emerged shortly after moderate COVID-19 infection. Laboratory studies revealed elevated inflammatory markers pronounced lymphopenia. was confirmed via serology PCR. Despite antiviral therapy, persisted, imaging necrotic Tuberculous lymphadenitis diagnosed through fine-needle aspiration cytology PCR detection Mycobacterium tuberculosis. The patient treated standard anti-tuberculosis regimen, resulting clinical, radiological, immunological improvement. Conclusions: underscores importance considering patients lymphadenopathy recent infections, regions high prevalence. also emphasizes need for thorough microbiological assessment post-viral syndromes. main takeaway that may create permissive environment system compromise.

Language: Английский

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