Current Topic in Lactic Acid Bacteria and Probiotics, Journal Year: 2024, Volume and Issue: 10(2), P. 63 - 74
Published: Dec. 1, 2024
Language: Английский
Pathogens, Journal Year: 2024, Volume and Issue: 13(11), P. 1005 - 1005
Published: Nov. 15, 2024
Recent advances in microbiome research have uncovered a dynamic and complex connection between the gut lungs, known as gut-lung axis. This bidirectional communication network plays critical role modulating immune responses maintaining respiratory health. Mediated by interactions, metabolic byproducts, microbial communities both organs, this axis demonstrates how gut-derived signals, such metabolites modulators, can reach lung tissue via systemic circulation, influencing function disease susceptibility. To explore implications of connection, we conducted systematic review studies published 2001 2024 (with much nearly 60% covering period 2020-2024), using keywords "gut-lung axis", "microbiome", "respiratory disease", "immune signaling". Studies were selected based on their relevance to mechanisms, impact dysbiosis, microbiota diseases. provides comprehensive overview axis, emphasizing its importance regulating inflammatory linked Understanding intricate pathway opens new avenues for microbiota-targeted therapeutic strategies, which could offer promising interventions diseases like asthma, chronic obstructive pulmonary disease, even infections. The insights gained through underscore potential novel target preventative approaches medicine, with enhancing
Language: Английский
Citations
3
The Journal of Microbiology, Journal Year: 2024, Volume and Issue: 62(9), P. 709 - 725
Published: Sept. 1, 2024
Language: Английский
Citations
2
Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3342 - 3342
Published: Sept. 29, 2024
The past several years have provided a more profound understanding of the role microbial species in lung. respiratory tract is delicate ecosystem bacteria, fungi, parasites, and viruses. Detecting DNA, pathogen-associated molecular patterns (PAMPs), metabolites sputum poised to revolutionize early diagnosis lung cancer. longitudinal monitoring microbiome holds potential predict treatment response side effects, enabling personalized effective options. However, most studies into microbiota been observational not adequately considered impact dietary intake air pollutants. This gap makes it challenging establish direct causal relationship between environmental exposure, changes composition microbiota, carcinogenesis, tumor progression. A holistic that considers both diet pollutants may pave way improved prevention management strategies for
Language: Английский
Citations
2
Immuno, Journal Year: 2024, Volume and Issue: 4(4), P. 502 - 520
Published: Nov. 8, 2024
Background. Several research findings suggest that sodium–glucose co-transporter 1 (SGLT1) is implicated in the progression and control of infections inflammation processes at pulmonary level. Moreover, our previous works indicate an engagement SGLT1 inhibiting inflammatory response induced intestinal epithelial cells by TLR agonists. In this study, we report anti-inflammatory effects observed lung upon transporter, use glucose BLF501, a synthetic ligand, for treatment animal models inflammation, including model allergic asthma. Methods. vitro experiments were carried out on human pneumocytes stimulated with LPS from Pseudomonas aeruginosa co-treated or production IL-8 was determined. The effect associated then assessed vivo LPS-induced injury, as well murine ovalbumin (OVA)-induced asthma, treating mice aerosolized ligand. After treatments, samples collected analyzed morphological alterations histological examination immunohistochemical analysis; serum BALF determination several pro- markers. Results. treated showed significant inhibition production. results two experimental models, exposed to OVA-induced revealed transport protein lungs. first model, acute respiratory distress abrogated co-treatment almost complete recovery morphology physiology. Similar both oral suggesting expressed alveolar cells. Conclusions. Our confirmed suggested non-metabolizable ligand co-transporter, might represent drug candidate therapeutic intervention against states.
Language: Английский
Citations
2
Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1170 - 1170
Published: June 8, 2024
Numerous studies have reported a correlation between gut microbiota and influenza A virus (IAV) infection disease severity. However, the causal relationship these factors remains inadequately explored. This investigation aimed to assess influence of on susceptibility human with H7N9 avian IAV severity (H1N1)pdm09 infection. two-sample Mendelian randomization analysis was conducted, integrating our in-house genome-wide association study (GWAS) H1N1pdm09 metagenomics GWAS dataset from Chinese population. Twelve fifteen microbiotas were causally associated or severity, separately. Notably, Clostridium hylemonae Faecalibacterium prausnitzii negative respectively. Moreover, Streptococcus peroris sanguinis susceptibility, while parasanguini suis correlated These results provide novel insights into interplay pathogenesis as well new clues for mechanism research regarding therapeutic interventions infections. Future should concentrate clarifying regulatory mechanisms developing efficacious approaches reduce incidence infections, which could improve strategy preventing treating worldwide.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7706 - 7706
Published: July 14, 2024
The communication mechanism of the gut–lung axis has received increasing attention in recent years, particularly acute respiratory infectious diseases such as influenza. peripheral immune system serves a crucial bridge between gut and lungs, two organs that are not close proximity to each other. However, specific involving microbiota, cells, their anti-influenza effects lung remains be further elucidated. In this study, 731 species cells 211 different microbiota on influenza outcomes were analyzed using two-sample Mendelian randomization analysis. After identifying associated with outcomes, mediation analyses conducted determine mediating protective or injurious mediated by microbiota. 19 75 types identified being susceptibility. rigorous screening, 12 combinations for effects. Notably, down-regulation CD64 CD14- CD16- 21.10% 18.55% effect Alcaligenaceae Dorea against influenza, respectively. conclusion, focusing study genetically inferred risk factors. Furthermore, analysis was used proportion microbiota-mediated susceptibility This helps elucidate which affects from perspective regulation cells.
Language: Английский
Citations
2
Seminars in Respiratory and Critical Care Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 25, 2024
Chronic obstructive pulmonary disease (COPD) is a common chronic seen in smokers associated with poor functional status, quality of life, and morbidity mortality from acute worsening symptoms, also called exacerbations. As disease, the risk factors for COPD are well defined; however, there room innovation identifying underlying biological processes, or "endotypes," that lead to emergence and/or progression COPD. Identifying endotypes allows more thorough understanding may reveal means prevention, be leveraged novel therapeutic approaches. In this review, we discuss interface viral infections both cellular epithelial immunity as potential endotype interest
Language: Английский
Citations
1
World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 31(5)
Published: Dec. 30, 2024
The human gut microbiota, a complex and diverse community of microorganisms, plays crucial role in maintaining overall health by influencing various physiological processes, including digestion, immune function, disease susceptibility. balance between beneficial harmful bacteria is essential for health, with dysbiosis - disruption this linked to numerous conditions such as metabolic disorders, autoimmune diseases, cancers. This review highlights key genera Enterococcus, Ruminococcus, Bacteroides, Bifidobacterium, Escherichia coli, Akkermansia muciniphila, Firmicutes (including Clostridium Lactobacillus), Roseburia due their well-established roles regulation but other bacteria, Clostridioides difficile, Salmonella, Helicobacter pylori, Fusobacterium nucleatum, are also implicated diseases. Pathogenic coli Bacteroides fragilis, contribute inflammation cancer progression disrupting responses damaging tissues. potential microbiota-based therapies, probiotics, prebiotics, fecal microbiota transplantation, dietary interventions, improve outcomes examined. Future research directions the integration multi-omics, impact diet lifestyle on composition, advancing engineering techniques discussed. Understanding microbiota's formulating personalized, efficacious treatments preventive strategies, thereby enhancing progressing microbiome research.
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105432 - 105432
Published: Nov. 7, 2024
Language: Английский
Citations
0
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Nov. 9, 2024
spp. cause bacillary dysentery (shigellosis) with high morbidity and mortality in low- middle-income countries. Infection occurs through the fecal-oral route can be devastating for vulnerable populations, including infants elderly. These bacteria invade host cells using a type III secretion system (T3SS). No licensed vaccine yet exists shigellosis, but we have generated recombinant fusion protein, L-DBF, combining T3SS needle tip protein (IpaD), translocator (IpaB), LTA1 subunit of enterotoxigenic
Language: Английский
Citations
0