International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 8641 - 8660
Published: Aug. 1, 2024
Osteosarcoma
is
the
predominant
primary
malignant
bone
tumor
that
poses
a
significant
global
health
challenge.
MicroRNAs
(miRNAs)
regulate
gene
expression
are
associated
with
osteosarcoma
pathogenesis.
Thus,
miRNAs
potential
therapeutic
targets
for
osteosarcoma.
Nanoparticles,
widely
used
targeted
drug
delivery,
facilitate
miRNA-based
treatment.
Numerous
studies
have
focused
on
miRNA
delivery
using
nanoparticles
to
inhibit
progress
of
Polymer-based,
lipid-based,
inorganic-based
and
extracellular
vesicles
were
deliver
treatment
They
can
be
modified
enhance
loading
capabilities.
Also,
was
combined
traditional
therapies,
example
chemotherapy,
treat
Consequently,
offers
promising
avenues
osteosarcoma,
providing
renewed
hope
patients.
This
review
emphasizes
utilizing
in
treatment,
then
introduced
summarized
detail.
And
it
also
discusses
prospects
clinical
applications.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(9), P. 241 - 241
Published: Aug. 23, 2024
The
rising
demand
for
effective
bone
regeneration
has
underscored
the
limitations
of
traditional
methods
like
autografts
and
allografts,
including
donor
site
morbidity
insufficient
biological
signaling.
This
review
examines
nanoparticles
(NPs)
in
tissue
engineering
(TE)
to
address
these
challenges,
evaluating
polymers,
metals,
ceramics,
composites
their
potential
enhance
osteogenesis
angiogenesis
by
mimicking
extracellular
matrix
(ECM)
nanostructure.
involved
synthesizing
characterizing
nanoparticle-based
scaffoldsand
integrating
hydroxyapatite
(HAp)
with
polymers
mechanical
properties
osteogenic
potential.
results
showed
that
NPs
significantly
promote
cell
growth,
differentiation,
formation,
carbon-based
graphene
carbon
nanotubes
showing
promise.
offer
versatile,
biocompatible,
customizable
scaffolds
drug
delivery
support
repair.
Despite
promising
results,
challenges
cytotoxicity,
biodistribution,
immune
responses
remain.
Addressing
issues
through
surface
modifications
biocompatible
molecules
can
improve
biocompatibility
efficacy
nanomaterials.
Future
research
should
focus
on
long-term
vivo
studies
assess
safety
NP-based
explore
synergistic
effects
other
bioactive
or
growth
factors.
underscores
transformative
advancing
BTE
calls
further
optimize
technologies
clinical
applications.
APL Materials,
Journal Year:
2024,
Volume and Issue:
12(8)
Published: Aug. 1, 2024
MXenes,
a
novel
class
of
two-dimensional
(2D)
materials,
have
attracted
considerable
attention
in
various
fields,
especially
drug
delivery,
wound
healing,
bone
tissue
engineering,
biosensing,
and
cancer
treatment.
Thanks
to
their
remarkable
physicochemical
properties,
MXenes
hold
great
promise
for
biomedical
applications.
Concurrently,
hydrogels
composed
polymers
been
extensively
utilized
contexts.
The
unique
properties
facilitate
integration
into
bioactive
with
enhanced
functions
thereby
endowing
the
composites
multifunctional
capabilities.
MXene-reinforced
polymer
(MRPHs)
synergistically
combine
advantageous
characteristics
both
hydrogels,
making
them
highly
adaptable
other
theranostic
strategies
medical
In
this
comprehensive
review,
we
demonstrate
recent
advances
design
synthesis
MRPHs
Specifically,
introduce
analyze
methods
tailoring
by
incorporating
active
components,
including
functional
molecules,
2D
metal
ions,
natural
polymers,
drugs/genes.
We
then
discuss
applications
designed
biosensors,
therapy.
hope
that
work
provides
valuable
guidance
inspiration
readers
develop
advanced
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101558 - 101558
Published: Feb. 5, 2025
The
regulation
of
bone
metabolic
microenvironment
imbalances
in
diseases
such
as
osteoporosis,
defects,
infections,
and
tumors
remains
a
significant
challenge
orthopedics.
Therefore,
it
has
become
urgent
to
develop
biomaterials
with
effective
microenvironmental
regulatory
functions.
Zeolites,
advanced
biomedical
materials,
possess
distinctive
physicochemical
properties
multi-level
pore
structures,
adjustable
frameworks,
easily
modifiable
surfaces,
excellent
adsorption
capabilities.
These
advantageous
characteristics
give
zeolites
broad
application
prospects
regulating
the
microenvironment.
this
paper
first
classifies
used
regulate
based
on
their
topological
structures
compositional
frameworks.
Subsequently,
provides
detailed
description
modification
strategies
for
zeolite
materials
aimed
at
Next,
comprehensive
summary
was
provided
preparation
Additionally,
focuses
specific
applications
conditions
imbalance,
orthopedic
tumors,
highlighting
potential
enhancing
osteogenic
microenvironments,
controlling
treating
tumors.
Finally,
outlines
challenges
associated
This
review
comprehensively
summarizes
regulation,
aiming
provide
guidance
future
research
development.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1574 - 1574
Published: Feb. 13, 2025
Near-infrared
light
(NIR)-responsive
metal-based
nanoparticles
(NPs)
could
be
used
for
tumour
therapy.
We
examined
how
platinum
(Pt),
gold
(Au),
and
core-shell
Pt-Au
NPs
affect
the
viability
of
human
hepatocellular
carcinoma
(HCC)
cell
lines
(Hep3B,
HepG2,
Huh7D-12)
alone
in
combination
with
NIR
exposure.
In
addition,
expression
immune
checkpoint
molecules
(ICMs)
on
cells
was
analysed.
revealed
that
cytotoxicity
programmed
death
induction
Au
toward
HCC
enhanced
by
960
nm
a
different
way.
were
only
particles
resulted
an
additional
temperature
increase
up
to
2
°C
after
NIR.
Regarding
phenotype,
not
all
experienced
changes
phenotype.
itself
trigger
alterations,
while
did
significantly
most
ICMs,
such
as
PD-L1,
HVEM,
CD70,
ICOS-L,
Ox40-L,
TNFRSF9.
The
prominent
ICMs
HepG2
cells.
conclude
thermotherapeutic
effect
NP
application
beneficial
multimodal
therapy
settings
liver
cancer
selected
patients.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: April 11, 2025
Photothermal
therapy
(PTT)
utilizes
photothermal
agents
(PTAs)
to
generate
heat
at
the
local
tumor
site
that
leads
ablation
upon
photoirradiation
a
specific
wavelength
of
light.
Currently,
most
available
PTAs
have
weak
selectivity
and
depositing
ability,
which
poor
therapeutic
outcomes.
PEGylation
improves
outcomes,
prolongs
systemic
circulation
time,
enhances
accumulation,
reduces
risk
clearance
by
immune
system.
This
paper
reviews
recent
developments
PEGylated
in
cancer
from
2019
2023,
highlighting
their
antitumour
efficacy
response
post-therapy
with
agents,
current
challenges
strategies.
review
aims
foster
knowledge
dissemination
on
application
nanomedicine
an
immunological
perspective
encourage
clinical
translation
these
nanomaterials.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5309 - 5309
Published: May 13, 2024
IR-783,
a
commercially
available
near-infrared
(NIR)
heptamethine
cyanine
dye,
has
been
used
for
selective
tumor
imaging
in
breast,
prostate,
cervical,
and
brain
cancers
vitro
vivo.
Although
the
molecular
mechanism
behind
structure-inherent
targeting
of
IR-783
not
well-demonstrated,
unique
properties
such
as
good
water
solubility
low
cytotoxicity
compared
with
other
commercial
dyes.
The
goal
this
study
is
to
evaluate
phototherapeutic
efficacy
tumor-targeted
photothermal
agent
human
colorectal
cancer
xenografts.
results
demonstrate
that
shows
both
subcellular
localization
HT-29
cells
preferential
accumulation
xenografted
tumors
24
h
after
its
intravenous
administration.
Furthermore,
dye
reveals
superior
capability
convert
NIR
light
into
heat
energy
under
808
nm
laser
irradiation
vivo,
thereby
inducing
cell
death.
Taken
together,
these
findings
suggest
water-soluble
anionic
can
be
bifunctional
targeted
therapy
(PTT)
cancer.
Therefore,
work
provides
simple
effective
approach
develop
biocompatible,
hydrophilic,
tumor-targetable
PTT
agents
phototherapy.
Biosurface and Biotribology,
Journal Year:
2024,
Volume and Issue:
10(2), P. 17 - 41
Published: June 1, 2024
Abstract
Due
to
trauma
and
disease,
bone
defects
endanger
the
healthy
life
of
human
beings.
At
present,
gold
standard
for
defect
repair
is
still
autologous
transplantation
allogeneic
transplantation.
However,
its
insufficient
source,
potential
disease
transmission
immune
rejection
limit
clinical
application.
Therefore,
development
materials
plays
an
important
role
in
promoting
repair.
As
interface
between
material
tissue,
surface
reaction
after
implantation,
which
determines
effectiveness
treatment.
With
engineering
technology,
have
developed
from
biological
inertia
activity
by
endowing
various
functions
controlling
composition,
topological
morphology
structure
etc.
The
inspired
biofunctionalisation
includes
capacities
inducing
osteogenesis,
angiogenesis,
antibacterial,
regulation
etc.,
as
well
integration
postoperative
authors
review
biomaterial
effects
repair,
mainly
including
physical
chemical
properties
regulate
functional
strategy
surface.
