Melatonin and the Skin: Current Progress and Perspectives for Human Health
Journal of Investigative Dermatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Silk Sericin in Dermatological Diseases: From Preclinical Studies to Future Clinical Applications
Monika Stradczuk‐Mazurek,
No information about this author
Łukasz Mazurek,
No information about this author
Marek Konop
No information about this author
et al.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 20, 2025
Abstract
Biomaterials
in
medicine
are
becoming
more
widespread
as
a
single
or
complementary
treatment
option.
One
such
biomaterial
is
silk,
comprised
of
two
primary
proteins:
fibroin
and
sericin.
Recently,
sericin's
anti‐inflammatory,
antioxidant,
moisturizing,
elastase‐
tyrosinase‐inhibiting
properties
have
been
widely
investigated.
Sericin
biomaterials
already
used
wound
healing
bone
tissue
engineering.
Additionally,
there
promising
results
for
its
usefulness
many
other
applications.
This
review
focuses
on
sericin
use
dermatological
diseases,
above
all
atopic
dermatitis
psoriasis.
proven
not
only
to
be
drug
carrier
but
also
improve
the
outcome
skin
lesions.
In
psoriasis,
therapeutic
effect
has
reduced
inflammation
abnormal
epidermal
maturation
plaques,
with
comparable
standard
treatment.
observed
diminish
pigmentation,
moisture,
increase
collagen
production
so
that
it
can
an
anti‐aging
product.
There
reports
anti‐skin‐cancer
activity.
paper
describes
mechanisms
behind
diseases'
pathogenesis
and,
based
scientific
studies,
highlights
explains
beneficial
effects
their
Its
versatility,
alone
combined
agents,
provides
new
opportunities
treatments
cosmetic
innovations.
Language: Английский
Biopolymeric Scaffolds with Melatonin for Tissue Engineering—A Review
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2520 - 2520
Published: March 11, 2025
Melatonin,
a
natural
hormone
with
antioxidant,
anti-inflammatory,
and
regenerative
properties,
has
gained
increasing
attention
in
tissue
engineering
for
its
ability
to
enhance
the
therapeutic
potential
of
biopolymeric
scaffolds.
These
scaffolds,
designed
mimic
extracellular
matrix,
provide
structural
support
bioactive
environment
regeneration.
By
integrating
melatonin,
researchers
aim
create
multifunctional
scaffolds
that
promote
cell
proliferation,
modulate
inflammatory
responses,
improve
wound
healing
outcomes.
Challenges
utilizing
melatonin
include
maintaining
stability
under
light,
heat,
oxygen
exposure,
optimizing
release
profile
sustained
effects.
Innovative
fabrication
methods,
such
as
electrospinning,
3D
printing,
lyophilization,
have
enabled
precise
control
over
scaffold
architecture
delivery.
techniques
ensure
enhanced
interactions
target
tissues
tailored
regeneration
processes.
Combining
growth
factors,
cytokines,
antimicrobial
agents
offers
applications,
from
chronic
management
bone
nerve
Continued
research
this
field
promises
transformative
solutions
medicine,
expanding
clinical
applicability
melatonin-enriched
This
review
highlights
current
progress,
challenges,
opportunities
associated
harnessing
melatonin’s
within
frameworks.
Language: Английский
Melatonin’s Impact on Wound Healing
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1197 - 1197
Published: Oct. 2, 2024
Melatonin
(5-methoxy-N-acetyltryptamine)
is
an
indoleamine
compound
that
plays
a
critical
role
in
the
regulation
of
circadian
rhythms.
While
melatonin
primarily
synthesized
from
amino
acid
tryptophan
pineal
gland
brain,
it
can
also
be
produced
locally
various
tissues,
such
as
skin
and
intestines.
Melatonin's
effects
target
tissues
mediated
through
receptor-dependent
mechanisms.
Additionally,
exerts
actions
via
receptor-independent
pathways.
In
biological
systems,
its
endogenous
metabolites
often
produce
similar
effects.
injuries
are
common
daily
life,
promoting
optimal
wound
healing
essential
for
patient
well-being
healthcare
outcomes.
Beyond
regulating
rhythms
neuroendocrine
hormone,
may
enhance
(1)
potent
antioxidant
properties,
(2)
anti-inflammatory
actions,
(3)
infection
control,
(4)
vascular
reactivity
angiogenesis,
(5)
analgesic
(pain-relieving)
effects,
(6)
anti-pruritic
(anti-itch)
This
review
aims
to
provide
comprehensive
overview
scientific
studies
demonstrate
melatonin's
potential
roles
supporting
effective
healing.
Language: Английский