Unprecedented Organogermanium Functionalized Ge^IV−Sb^III‐Templating Polyoxotungstate Nanocluster for Photothermal–Chemodynamic Cancer Therapy

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: July 30, 2024

Abstract The function‐oriented synthesis of polyoxometalate (POM) nanoclusters has become an increasingly important area research. Herein, the well‐known broad‐spectrum anticancer drug Ge‐132 which contains Ge IV as potential heteroatoms and carboxyl coordination sites, is introduced to POM system, leading first organogermanium functionalized −Sb III ‐templating nanocluster Na 4 [H 2 N(CH 3 ) ] 16 H 18 [Sm (H O) 12 W O 14 Ge(CH CH COOH)] [SbW 9 33 [Ge(CH COOH) SbW 15 54 ·62H ( 1 ). An unprecedented templating Dawson‐like COOH)SbW 12− building block discovered. To take advantage pharmaceutical activity such organogermanium‐functionalized cluster, further composited with gold nanoparticles (NPs) prepare −Au NPs, doubles blood circulation time ‐based nanodrug. Efficient separation photogenerated charges in NPs largely boosts photothermal conversion efficiency (PCE = 55.0%), nearly 2.1 times that either single 26.7%) or Au 26.2%), simultaneously facilitate generation toxic activate reactive oxygen species tumor microenvironment. Based on these findings, it demonstrated are a multifunctional renal clearable nanomedicine great photoacoustic imaging guiding photothermal–chemodynamic therapy for breast cancer.

Language: Английский

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Antitubercular activity of silver(I) complexes with 7-chloro-4-aminoquinolines: synthesis, characterization and in vitro biological assays

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 9, 2025

This article describes the synthesis, characterization, and biological activity of four quinoline derivatives, ACQ12, ACQ13, ACQ14, ACQophen, their respective silver(I) complexes. The organic compounds are composed 4,7-dichloroquinoline derivatives containing aliphatic diamines, 1,2-ethanediamine (ACQ12), 1,3-propanediamine (ACQ13), 1,4-butanediamine (ACQ14), an aromatic diamine, o-phenylenediamine (ACQophen), as a side chain at 4-position ring. crystalline structure ACQophen was solved by single crystal X-ray diffraction, while structures Ag-ACQ12 (1), Ag-ACQ13 (2), Ag-ACQ14 (3), Ag-ACQophen (4) were obtained polycrystals diffraction technique. Silver complexes have shown 1:1 (M:L) molar ratio. Further characterization in all performed analytical methods spectroscopic techniques. Elemental analyses, conductometry IR, Raman UV–Vis spectroscopies confirmed proposed molecular formulas. Coordination occurs through nitrogen atom Biological assays vitro for synthesized against Mycobacterium tuberculosis H37Rv American Type Collection Culture 27294 (ATCC 27294). Free aminoquinolines 3 4 showed MIC90 below 13.0 mg L−1. selectivity index (SI) over 190 its Ag(I) complex has SI = 3.09, making these promising antimycobacterial agents.

Language: Английский

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Guanidinium and spermidinium decavanadates: as small biomimetic models to understand non-covalent interactions between decavanadate and arginine and lysine side chains in proteins

Frontiers in Chemical Biology, Journal Year: 2024, Volume and Issue: 3

Published: Aug. 12, 2024

During the last three decades, numerous investigations have been conducted on polyoxidovanadates to treat several illnesses and inhibit enzymes. Numerous decavanadate compounds proposed as potential therapies for Diabetes mellitus, Cancer, Alzheimer’s disease. Only six relevant functional proteins interacting with decavanadate, V 10 , deposited in PDB. These are acid phosphatase, tyrosine kinase, two ecto-nucleoside triphosphate diphosphohydrolases (NTPDases), human transient receptor cation channel (TRPM4), cell cycle protein CksHs1. The interaction sites these mainly consist of Arginine Lysine, side chains binding anion. To get further knowledge regarding non-covalent interactions environments, guanidinium spermidinium decavanadates were synthesized, crystallized, subjected analysis utilizing various techniques, including FTIR, Raman, 51 V-NMR, TGA, X-ray diffraction. DFT calculations employed calculate energy between anion organic counterions. Furthermore, Quantum Theory Atoms Molecules (QTAIM) Non-covalent Interaction-Reduced Density Gradient (NCI-RDG) analyses understand present adducts. Decavanadate can engage electrostatic forces, van der Waals, hydrogen bond spermidinium, shown by their respective energies. Both highly stabilized strong N−H···O weak C−H···O. In addition, cations form stable rings. This study provides new information intermolecular small biomimetic models arginine lysine lateral environments.

Language: Английский

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Insights into the Theranostic Activity of Nonoxido V^IV: Lysosome-Targeted Anticancer Metallodrugs

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(41), P. 19418 - 19438

Published: Sept. 28, 2024

Developing new anticancer agents can be useful, with the ability to diagnose and treat cancer worldwide. Previously, we focused on examining effects of nonoxidovanadium(IV) complexes insulin mimetic cytotoxicity activity. In this study, in addition cytotoxic activity, evaluated their bioimaging properties. This study investigates synthesis four stable nonoxido V

Language: Английский

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Sub‐Nanosheet Induced Inverse Growth of Negative Valency Au Clusters for Tumor Treatment by Enhanced Oxidative Stress

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Cluster aggregation states are thermodynamically favored at the subnanoscale, for which an inverse growth from nanoparticles to clusters may be realized on subnanometer supports. Herein, we develop Au-polyoxometalate-layered double hydroxide (Au-POM-LDH) sub-1 nm nanosheets (Sub-APL) based above strategy, where Au with negative valence generated by in situ disintegration of POM-LDH Sub-1 ultrahigh surface atom ratios exhibit remarkable efficiency glutathione (GSH) depletion. The closely connected and POM hetero-units can promote separation hole-electrons, resulting enhanced reactive oxygen species (ROS) generation under ultrasound (US). Besides, reversible redox Mo is able deplete GSH trigger chemodynamic therapy (CDT) simultaneously, further enhancing oxidative stress. Consequently, Sub-APL present 2-fold ROS US 7-fold depletion compared discrete mixture. Therefore, serious imbalance TME caused sharp increase rapid decrease leads death tumor ultimately.

Language: Английский

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Sub‐Nanosheet Induced Inverse Growth of Negative Valency Au Clusters for Tumor Treatment by Enhanced Oxidative Stress

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(40)

Published: July 5, 2024

Abstract Cluster aggregation states are thermodynamically favored at the subnanoscale, for which an inverse growth from nanoparticles to clusters may be realized on subnanometer supports. Herein, we develop Au‐polyoxometalate‐layered double hydroxide (Au‐POM‐LDH) sub‐1 nm nanosheets (Sub‐APL) based above strategy, where Au with negative valence generated by in situ disintegration of POM‐LDH Sub‐1 ultrahigh surface atom ratios exhibit remarkable efficiency glutathione (GSH) depletion. The closely connected and POM hetero‐units can promote separation hole‐electrons, resulting enhanced reactive oxygen species (ROS) generation under ultrasound (US). Besides, reversible redox Mo is able deplete GSH trigger chemodynamic therapy (CDT) simultaneously, further enhancing oxidative stress. Consequently, Sub‐APL present 2‐fold ROS US 7‐fold depletion compared discrete mixture. Therefore, serious imbalance TME caused sharp increase rapid decrease leads death tumor ultimately.

Language: Английский

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Mechanism of Metal Complexes in Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11873 - 11873

Published: Nov. 5, 2024

Alzheimer's disease (AD) is a kind of neurodegenerative diseases characterized by beta-amyloid deposition and neurofibrillary tangles also the main cause dementia. According to statistics, incidence AD constantly increasing, bringing great burden individuals society. Nonetheless, there no cure for AD, available drugs are very limited apart from cholinesterase inhibitors N-Methyl-D-aspartic acid (NMDA) antagonists, which merely alleviate symptoms without delaying progression disease. Therefore, an urgent need develop medicine that can delay or it. In recent years, increasing evidence suggests metal complexes have enormous potential treat through inhibiting aggregation cytotoxicity Aβ, interfering with congregation hyperphosphorylation tau, regulating dysfunctional synaptic unbalanced neurotransmitters, etc. this review, we summarize current their mechanisms action treating including ruthenium, platinum, zinc, vanadium, copper, magnesium, other complexes.

Language: Английский

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