Bats as instructive animal models for studying longevity and aging DOI Creative Commons
Lisa Noelle Cooper, M. Y. Ansari, Grace Capshaw

et al.

Annals of the New York Academy of Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Bats (order Chiroptera) are emerging as instructive animal models for aging studies. Unlike some common laboratory species, they meet a central criterion studies: live long time in the wild or captivity, 20, 30, and even >40 years. Healthy (i.e., healthspan) bats has drawn attention to their potential improve lives of humans due bat imperviousness viral infections, apparent low rate tumorigenesis, unique ability repair DNA. At same time, longevity also permits accumulation age‐associated systemic pathologies that can be examined detail manipulated, especially captive animals. Research uncovered additional critical advantages bats. In multiple ways, better analogs than rodents. this review, we highlight eight diverse areas research with relevance aging: genome sequencing, telomeres, DNA repair; immunity inflammation; hearing; menstruation menopause; skeletal system fragility; neurobiology neurodegeneration; stem cells; senescence mortality. These examples demonstrate broad an model point directions particularly important human

Language: Английский

Lmx1a is essential for marginal cell differentiation and stria vascularis formation DOI Creative Commons
Justine Renauld, Igor Y. Iskusnykh, Ebenezer N. Yamoah

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

The transcription factor Lmx1a is widely expressed during early inner ear development, and mice lacking expression exhibit fusion of cochlear vestibular hair cells fail to form the ductus reuniens endolymphatic sac. dreher (Lmx1a dr/dr ), a recessive null mutation, results in non-functional expression, which expands from outer sulcus stria vascularis Reissner's membrane. In absence Lmx1a, we observe lack proteins specific vascularis, such as BSND KCNQ1 marginal CD44 intermediate cells. Further analysis superficial epithelial cell layer at expected location shows that future migrate embryonic development but subsequently disappear. Using antibodies against pendrin (Slc26a4) knockout (KO) mice, an expansion across Moreover, no endocochlear potential observed. These findings highlight critical role particularly differentiation structures, recruitment pigment cells, essential for hearing balance.

Language: Английский

Citations

2
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation DOI

Dongye Guo,

Jichang Wu,

Chenling Shen

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Jan. 31, 2025

Language: Английский

Citations

0
Metabolomic and Cellular Mechanisms of Drug‐Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation DOI Creative Commons

Suhan Guo,

Cheng Cheng, Yunhao Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Certain medications, including cisplatin and neomycin, often cause both hearing loss renal dysfunction. This study aims to uncover the common mechanisms behind drug-induced ototoxicity nephrotoxicity aid early diagnosis treatment. Metabolomic analyses reveal simultaneous disruptions in endogenous metabolic networks kidney, inner ear, serum after administrating or neomycin. Notably, a marked elevation uric acid (UA), recognized indicator of tubular injury, is identified. Supplementing UA inhibiting its excretion worsen hair cell damage. Single-cell nucleus sequencing immunohistochemistry major changes xanthine oxidase ABCG2, crucial for metabolism, primarily cochlear stria vascularis cells rather than cells. Cisplatin triggers significant release from cells, reaching concentrations sufficient induce autophagy-dependent ferroptosis In coculture system, targeted interventions against these two proteins through either pharmacological inhibition genetic manipulation, markedly decrease elevated subsequent These findings suggest connection between ear highlighting therapeutic potential modulating mitigate ototoxicity.

Language: Английский

Citations

0
The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery DOI Creative Commons
Zhangyi Yi, Xiaoying Wang,

Ge Yin

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 482 - 482

Published: April 7, 2025

The inner ear is a relatively isolated organ, protected by the blood-labyrinth barrier (BLB). This creates unique lymphatic fluid environment within ear, maintaining stable physiological state essential for mechano-electrical transduction process in hair cells while simultaneously restricting most drugs from entering fluid. Under pathological conditions, dysfunction of stria vascularis and disruption structure can lead to temporary or permanent hearing impairment. review describes function BLB, along with recent advancements modeling protective studies related BLB. emphasizes some newly developed non-invasive drug delivery strategies, including ultrasound therapy assisted microbubbles, ear-targeting peptides, sound therapy, route administration cerebrospinal conduit. We argue that intrinsic properties BLB be strategically utilized effective delivery.

Language: Английский

Citations

0
Bats as instructive animal models for studying longevity and aging DOI Creative Commons
Lisa Noelle Cooper, M. Y. Ansari, Grace Capshaw

et al.

Annals of the New York Academy of Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Bats (order Chiroptera) are emerging as instructive animal models for aging studies. Unlike some common laboratory species, they meet a central criterion studies: live long time in the wild or captivity, 20, 30, and even >40 years. Healthy (i.e., healthspan) bats has drawn attention to their potential improve lives of humans due bat imperviousness viral infections, apparent low rate tumorigenesis, unique ability repair DNA. At same time, longevity also permits accumulation age‐associated systemic pathologies that can be examined detail manipulated, especially captive animals. Research uncovered additional critical advantages bats. In multiple ways, better analogs than rodents. this review, we highlight eight diverse areas research with relevance aging: genome sequencing, telomeres, DNA repair; immunity inflammation; hearing; menstruation menopause; skeletal system fragility; neurobiology neurodegeneration; stem cells; senescence mortality. These examples demonstrate broad an model point directions particularly important human

Language: Английский

Citations

3