Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12738 - 12738

Published: Nov. 27, 2024

Cannabis sativa L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids cannabinoids, particularly Δ-9-tetrahydrocannabinol (THC) cannabidiol (CBD). Cannabinoids have an effect on endocannabinoid system (ECS), a cellular communication network, are, hence, widely studied for medical applications. Epidiolex®, 99% pure oral CBD extract, has been approved by FDA treatment of epilepsy. Nabiximols (Sativex) is oromucosal spray containing equal volume THC CBD, it commonly used as add-on unresponsive spasticity in multiple sclerosis (MS) patients. Several vitro vivo studies also shown that cannabinoids can be to treat various types cancer, such melanoma brain glioblastoma; first positive clinical trials anticancer THC:CBD blend temozolomide (TMZ) highly invasive cancer are very promising. The exert their properties investigations induction cell death, mainly apoptosis cytotoxic autophagy, inhibition proliferation. In several studies, found induce tumor regression inhibit angiogenic mechanisms vivo, well two low-numbered epidemiological studies. They exhibit antiviral effects inhibiting ACE2 transcription, blocking viral replication fusion, acting agents; indeed, prior consumption (a study 93,565 persons Chicago) associated much lower incidence SARS-CoV-2 infections. It postulated cannabis extracts many other diseases systemic lupus erythematosus, type 1 diabetes, or neurological disorders, e.g., Alzheimer’s disease. aim this review outline current state knowledge regarding currently medicinal preparations derived from C. selected diseases, present latest research potential applications its secondary metabolites.

Language: Английский

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Cannabinoids as Promising Inhibitors of HER2-Tyrosine Kinase: A Novel Strategy for Targeting HER2-Positive Ovarian Cancer

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 6191 - 6200

Published: Feb. 8, 2025

Human epidermal growth factor receptor 2 (HER2) is a transmembrane within the ErbB family that plays pivotal role in progression of various aggressive cancers. HER2-positive tumors often develop resistance to standard therapies, necessitating exploration innovative treatment options. Cannabinoids, bioactive compounds from Cannabis sativa such as cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN), have gained attention for their potential anticancer properties. This study evaluates efficacy CBD, CBG, CBN targeting ovarian cancer through kinase inhibition assays, surface plasmon resonance (SPR), molecular docking, cell viability assessments. SPR analysis revealed cannabinoids bind strongly HER2-tyrosine (HER2-TK), with CBD showing highest affinity (K D = 6.16 μM), significantly better than afatinib 26.30 CBG demonstrating moderate 17.07 μM). In was most potent inhibitor (IC50 24.7 nM), followed by 38 suggesting ability disrupt HER2-mediated signaling pathways. Molecular docking studies highlighted critical interactions between essential HER2 residues (Leu796, Thr862, Asp863). effectively inhibited SKOV3 cells 13.8 μM 16.6 μM, respectively), comparable traditional tyrosine inhibitors. These findings underscore therapeutic cannabinoids, particularly alternative or adjunct therapies cancers, promise mitigating adverse effects associated existing treatments.

Language: Английский

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Research mapping of cannabinoids and endocannabinoid system in cancer over the past three decades: insights from bibliometric analysis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

Background The cannabinoids and endocannabinoid system are thought to play critical roles in multiple signaling pathways organisms, extensive evidence from preclinical studies indicated that endocannabinoids displayed anticancer potential. This study aimed summarize the research of cancer through bibliometric analysis. Methods Relevant literature field published during 1995–2024 were collected Web Science Core Collection database. VOSviewer SCImago Graphica applied perform analysis countries, institutions, authors, journals, documents, keywords. Results A total 3,052 publications identified, global output exhibited a generally upward trend over past 3 decades. USA had greatest number citations this field. Italian National Research Council led terms publication, while Complutense University Madrid highest citations. Vincenzo Di Marzo was leading author with co-occurrence keywords revealed frontiers mainly included “cannabinoids”, “endocannabinoid system”, “cancer”, “anandamide”, “cannabidiol”, “cannabinoid receptor”, “apoptosis”, “proliferation”. Conclusion Our results would receive continuous attention. Italy have made remarkable contributions field, supported by their influential institutions prolific scholars. emphasis has evolved basic functional characterization mechanistic exploration disease translational applications within multidisciplinary framework.

Language: Английский

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Cannabidiol as a novel therapeutic agent in breast cancer: evidence from literature

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Language: Английский

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THE MULTIPLE APPLICATIONS OF INDUSTRIAL HEMP (CANNABIS SATIVA L.) IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT

INMATEH Agricultural Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 1051 - 1071

Published: April 30, 2025

This review explores the multiple directions of industrial hemp (Cannabis sativa L.) utilization at a global level, highlighting importance this crop as renewable, sustainable, and environmentally friendly resource. While has traditionally been employed for production fibers, seeds, medicinal products, recent studies have expanded its applications into innovative fields such eco-friendly construction materials (e.g., hempcrete composite materials), automotive aerospace industries, cosmetics, biofuels, others. The remarkable properties hemp, including low density, superior mechanical strength, carbon sequestration capability, moisture regulation, help reduce energy consumption enhance performance materials, thereby providing competitive advantages in sustainability-oriented sectors. Moreover, extracts oils, rich bioactive compounds (essential fatty acids, vitamins, antioxidants, cannabinoids), demonstrated therapeutic potential, reinforcing role development food, cosmetic, pharmaceutical products. Additionally, significantly contributes to phytoremediation by absorbing heavy metals contaminants from soil, fibers stand out their durability resistance, being valued textile industry ecological characteristics performance. Industrial stands high versatility, valuable along with favorable environmental impact, support integration wide range sectors, opening promising perspectives more sustainable responsible future.

Language: Английский

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The molecular anti-metastatic potential of CBD and THC from Lebanese Cannabis via apoptosis induction and alterations in autophagy

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 27, 2024

The medicinal plant Cannabis sativa L. (C. sativa) is currently being extensively studied to determine the full extent of its therapeutic pharmacological potential. Δ9-tetrahydocannabinol (THC) and cannabidiol (CBD) are most thoroughly investigated compounds. We aimed explore anticancer activity cannabinoids mixture isolated from Lebanese C. in ratios comparable local plant, elucidate mechanism action breast cancer cells vitro. Cells were subjected cytotoxicity assay, cell cycle analysis, Annexin V/PI dual staining, death ELISA, immunofluorescence, addition western blot analysis apoptotic autophagy markers. further evaluated anti-metastatic effect on MDA-MB-231 using scratch wound-healing, trans-well migration invasion assays. Our results revealed promising benefits CBD/THC inhibiting growth by promoting cellular fragmentation, phosphatidylserine translocation outer membrane leaflet DNA fragmentation both lines while motility triple negative cells. In our study, was found exhibit a pro-apoptotic via activation mitochondrial pathway, independent ROS production also suggesting caspase-dependent pathway. Even though altered upon exposure cannabinoid mixture, data suggested that it not responsible inducing death. conclusion, study demonstrates CBD THC

Language: Английский

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Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 4, 2024

Cannabis and its derivatives show encouraging therapeutic effects in the treatment of various diseases. However, further studies are needed to better assess their efficacy safety. A promising base for research field medicine additional pharmacovigilance is social networks, which experience knowledge exchanged between researchers, doctors, patients, as well information about potential risks benefits using drugs medical purposes disseminated. The aim this study was investigate reported efficiency safety use cannabinoids patients posts on media Instagram analyze observed trends.

Language: Английский

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Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 534 - 534

Published: Dec. 11, 2024

The increasing use of Cannabis sativa products for medicinal, dietary, and recreational purposes has raised concerns about mycotoxin contamination in cannabis hemp. Mycotoxins persist these products’ post-processing, posing health risks via multiple exposure routes. This study investigated cytotoxic genotoxic interactions between cannabidiol (CBD) the citrinin (CIT) using human cell models: SH-SY5Y, HepG2, HEK293, peripheral blood lymphocytes. IC50 values membrane disruption were initially assessed, followed by an evaluation genotoxicity lymphocytes Comet Assay Cytokinesis Blocked Micronucleus Cytome Assay. Obtained findings demonstrate that cell-type sensitivity varied across treatments, with combined CBD CIT exhibiting distinct interactions. Lactate dehydrogenase (LDH) release remained minimal, suggesting cytotoxicity did not stem from but likely involved intracellular pathways. In lymphocytes, alone produced negligible cyto/genotoxic effects weak antiproliferative responses, whereas displayed clear toxic impacts. DNA damage indicates may induce genome instability through indirect mechanisms rather than direct interaction, evidence potential aneuploidic CBMN Cyt Combined led to a reduction CIT-induced cytogenetic damage, CIT’s interference beneficial properties CBD. These results provide foundation further toxicological assessments highlight necessity standardized monitoring cannabis-derived products.

Language: Английский

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New Relevant Evidence in Cholangiocarcinoma Biology and Characterization

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4239 - 4239

Published: Dec. 19, 2024

Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature this tumor, particularly in its early stages, well high heterogeneity at genomic, epigenetic, molecular levels delay diagnosis, significantly compromising efficacy current therapeutic options thus contributing a dismal prognosis. Extensive research has been conducted on pathobiology CCA, recent advances have made classification characterization new targets. Both targeted therapy immunotherapy emerged effective safe strategies for various types cancers, demonstrating potential benefits advanced CCA. Furthermore, deeper comprehension cellular components tumor microenvironment (TME) opened up possibilities innovative treatment methods. This review discusses evidence biology highlighting novel possible druggable

Language: Английский

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