Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(20)

Published: Oct. 1, 2024

ABSTRACT Background Circadian rhythms are approximately 24‐hour cycles in physiological and behavioral processes. They entrained to the external solar day via blue wavelength light. Disruptions these intrinsic can lead circadian dysfunction, which has several negative implications on human health, including cancer development progression. Aims Here we review molecular mechanisms of disruption their impact tumor progression, discuss interplay between dysfunction basic scientific studies clinical data, propose potential data that may be used improve patient outcomes reduce cost treatment. Materials & Methods Using literature databases, relevant were analyzed draw overarching conclusions relationship rhythm dysruption cancer. Conclusions mediated by a number environmental factors such as exposure light at night, shift work, jetlag, social jetlag drive oncogenesis. Tumor growth well treatment, long‐term alterations negatively affect quality life survivors.

Language: Английский

Regular exercise suppresses steatosis‐associated liver cancer development by degrading E2F1 and c‐Myc via circadian gene upregulation

Genes to Cells, Journal Year: 2024, Volume and Issue: 29(11), P. 1012 - 1025

Published: Oct. 2, 2024

Abstract Regular exercise is believed to suppress cancer progression. However, the precise molecular mechanisms by which prevents development remain unclear. In this study, using a steatosis‐associated liver mouse model, we found that regular at speed of 18 m/min for 20 min daily suppressed development. To explore underlying mechanisms, examined gene expression profiles in livers and non‐exercise groups. The expressions circadian genes, such as Per1 Cry2, were upregulated group. As rhythm disruption known cause various diseases, including cancer, improving through could contribute prevention. We further series E2F1 c‐Myc target genes directly affect proliferation cells was downregulated transcriptionally unchanged but degraded post‐translational level exercise. regulated Skp1‐Cul1‐FBXL3 (SCF FBXL3 ) ubiquitin ligase complex binding FBXL3, can form with c‐Myc, think mechanism degrade them. Our study revealed previously unknown

Language: Английский

Cronobiología y aplicaciones médicas (I). Los ritmos circadianos

Medicine - Programa de Formación Médica Continuada Acreditado, Journal Year: 2024, Volume and Issue: 14(23), P. 1350 - 1363

Published: Dec. 1, 2024