Biolohichni systemy,
Journal Year:
2024,
Volume and Issue:
16(1), P. 46 - 52
Published: Jan. 1, 2024
The
honey
bee
(Apis
mellifera
L.),
the
main
pollinator
of
entomophilous
plants,
is
one
most
important
insects
natural
ecosystems
and
a
producer
such
products
as
honey,
perga,
royal
jelly,
wax,
propolis
etc.
efficiency
beekeeping
limited
by
many
factors,
which
survival
colonies
in
critical
periods
development,
especially
conditions
widespread
use
artificial
feed.
Diets
that
do
not
meet
vital
needs
bees
full
nutrition
negatively
affect
their
health.
aim
study
was
to
evaluate
level
lipid
peroxidation
(LPO),
marker
development
stress,
foraging
Apis
carnica,
consumed
different
carbohydrate
diets
laboratory
for
14
hours.
Bees
were
selected
from
outermost
combs
July,
40-50
individuals
into
feeder
boxes,
transported
kept
hours
at
25°С
thermostat
on
following
diets:
Group
I
–
30%
sucrose
solution;
II
sugar
III
60%
IV
V
glucose
VI
fructose
VII
solution
+
(1:1);
VIII
15%
IX
32%
solution.
control
group
frozen
with
liquid
nitrogen,
apiary,
experimental
groups
-
after
end
experiment;
stored
minus
70
°C
until
biochemical
studies.
LPO
determined
separate
tags
(head,
thorax,
abdomen)
according
Placer's
method
modifications.
It
found
transfer
transportation
keeping
small
cluster
forager
significant
stress
factor
them,
evidenced
increase
tissues
insects'
heads.
lowest
observed
head
abdomen
boxes
fourteen
diet
compared
(30%),
(30
%
60%)
diets,
mixture
monosugars
(15%
30%)
honey.
Keywords
mellifera,
diet,
peroxidation,
hour
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3741 - 3741
Published: Oct. 31, 2024
Conventional
cancer
treatments
include
surgical
resection,
chemotherapy,
hyperthermia,
immunotherapy,
hormone
therapy,
and
locally
targeted
therapies
such
as
radiation
therapy.
Standard
often
require
the
use
of
multiple
agents,
which
can
activate
nuclear
factor
kappa
B
(NF-κB)
in
tumor
cells,
leading
to
reduced
cell
death
increased
drug
resistance.
Moreover,
agents
also
contributes
added
toxicity,
resulting
poor
treatment
outcomes.
Cancer
cells
gradually
develop
resistance
almost
all
chemotherapeutics
through
various
mechanisms,
efflux,
alterations
metabolism
transport,
changes
signal
transduction
pathways,
enhanced
DNA
repair
capacity,
evasion
apoptosis,
mutations,
reactivation
targets,
interaction
with
microenvironment,
cell-stroma
interactions,
epithelial–mesenchymal
transition
(EMT)-mediated
chemoresistance,
epigenetic
modifications,
metabolic
alterations,
effect
stem
(CSCs).
Developing
new
strategies
improve
chemotherapy
sensitivity
while
minimizing
side
effects
is
essential
for
achieving
better
therapeutic
outcomes
enhancing
patients’
quality
life.
One
promising
approach
involves
combining
conventional
propolis
its
flavonoids.
These
natural
compounds
may
enhance
response
reducing
toxicity.
Propolis
components
sensitize
chemotherapeutic
likely
by
inhibiting
NF-κB
activation,
reprogramming
tumor-associated
macrophages
(TAMs;
an
M2-like
phenotype),
thereby
release
matrix
metalloproteinase
(MMP)-9,
cytokines,
chemokines,
vascular
endothelial
growth
(VEGF).
By
TAMs,
overcome
EMT-mediated
disrupt
crosstalk
between
CSCs,
inhibit
maintenance
stemness,
reverse
acquired
immunosuppression,
thus
promoting
antitumor
mediated
cytotoxic
T-cells.
This
review
highlights
potential
flavonoids
modulate
responsiveness
modalities.
The
evidence
suggests
that
novel
incorporating
could
be
developed
positive
cytotoxicity
peripheral
blood
leukocytes,
liver,
kidney
cells.
Therefore,
polyphenolic/flavonoid
hold
combination
clinical
types
cancers.
EXPERIMENTAL ANIMALS,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Royal
jelly
(RJ)
is
recognized
due
to
its
high
nutritional
value
and
potential
health
benefits.
Previous
research
showed
that
RJ
supplementation
decreased
fat
accumulation,
resulting
in
weight
loss
improvements
hyperglycemia
insulin
resistance
high-fat
diet
(HFD)-induced
obese
mice.
To
expand
the
weight-reducing
properties
of
RJ,
this
study
aimed
investigate
effects
on
HFD-induced
mice
with
impaired
sleep
stabilization.
Over
a
20-week
period,
C57BL/6J
were
divided
into
following
dietary
groups:
normal
(ND),
ND
supplemented
5%
lyophilized
powder
(ND
+
RJ),
HFD,
HFD
(HFD
RJ)
groups.
Compared
group,
group
exhibited
significant
reduction
body
via
decrease
mass.
Moreover,
much
like
demonstrated
fragmentation
non-rapid
eye
movement
(NREM)
wakefulness.
These
processes
contributed
reestablishment
sleep/wake
continuity
restored
overall
stability
sleep.
In
contrast,
groups
similar
architecture.
Thus,
no
substantial
effect
sleep/wake.
According
these
findings,
improves
architecture
restores
stability.
Hence,
promising
component
for
addressing
obesity
restoring
The
application
of
green
synthesis
in
nanotechnology
is
rapidly
expanding
as
a
safe
and
eco-friendly
alternative
to
conventional
methods.
This
study
explored
the
potential
royal
jelly
bio-reducing
agent
for
synthesizing
metal
nanoparticles
evaluated
their
antibacterial
activity.
Royal
exhibited
strong
antioxidant
activity,
demonstrated
by
ABTS
(2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate))
DPPH
(2,2-diphenyl-1-picrylhydrazyl)
assays,
comparable
that
Trolox.
However,
it
showed
weak
effects
against
both
Gram-positive
Gram-negative
bacteria.
Using
jelly,
silver,
iron,
copper,
zinc
were
synthesized,
confirmed
Fourier
Transform
Infrared
Spectrometer
(FTIR),
ultraviolet-visible
(UV-Vis),
fluorescence
spectroscopy,
morphological
analyses.
significant
disrupting
bacterial
cell
walls
killing
bacteria,
shown
inhibition
zone
minimum
inhibitory
concentrations
(MIC),
bactericidal
(MBC),
scanning
electron
microscope
(SEM)
imaging.
research
highlights
jelly's
dual
role
reducing
nanoparticle
its
applications.
Acta Parasitologica,
Journal Year:
2025,
Volume and Issue:
70(1)
Published: Jan. 24, 2025
Abstract
Purpose
Encephalitozoon
intestinalis
is
an
obligate
intracellular
microsporidian
fungus
that
causes
severe
gastrointestinal
infections,
particularly
in
immunocompromised
individuals.
Propolis
(PROP),
a
resinous
substance
derived
from
bees,
has
antimicrobial,
anti-inflammatory
and
antioxidant
properties,
while
royal
jelly
(RJ)
immunomodulatory,
antimicrobial
activities.
The
aim
of
this
study
was
to
investigate
the
therapeutic
potential
PROP
RJ
against
E.
intestinalis.
Methods
phenolic
composition
analysed
by
high-performance
liquid
chromatography
with
diode
array
detection,
chemical
components
were
evaluated
according
ISO12824
standards.
cytotoxicity
on
HEK-293
cells
using
XTT
assay.
three
highest
non-cytotoxic
concentrations
each
sample
tested
for
their
effects
spores
qRT-PCR.
Trichrome-stained
photomicrographs
used
assess
spore
density
treated
RJ.
Results
analysis
revealed
flavonoids
such
as
quercetin,
kaempferol,
pinocembrin
galangin,
well
acids
caffeic
cinnamic
acids,
known
bioactive
properties.
contained
mainly
proteins,
lipids,
carbohydrates
sugars,
reflecting
its
role
nutritionally
biologically
active
substance.
According
results
first
evaluating
effect
intestinalis,
all
showed
significant
inhibitory
growth
compared
control
group.
Conclusion
In
conclusion,
we
believe
should
be
considered
alternative
option
development
antimicrosporidial
drugs
due
medicinal
pharmaceutical
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(2), P. 172 - 172
Published: Feb. 10, 2025
Hive
products,
encompassing
honey,
propolis,
bee
venom,
royal
jelly,
and
pollen,
are
recognized
for
their
antimicrobial
therapeutic
properties.
This
review
examines
chemical
composition,
explores
mechanisms
of
action,
discusses
potential
applications
in
both
human
veterinary
medicine,
particularly
addressing
the
challenge
resistance.
study
utilized
a
comprehensive
literature
search
strategy,
gathering
data
from
Google
Scholar,
MEDLINE
PubMed,
SciELO,
SCOPUS
databases.
Relevant
terms
were
employed
to
ensure
thorough
retrieval
pertinent
literature.
Honey,
rich
bioactive
compounds
such
as
hydrogen
peroxide
methylglyoxal,
effectively
disrupts
biofilms
combats
multi-drug-resistant
pathogens,
showing
promise
treating
range
infections.
Propolis,
with
its
flavonoids
phenolic
acids,
demonstrates
synergistic
effects
when
used
conjunction
antibiotics.
Bee
component
melittin,
exhibits
antibacterial
immunomodulatory
properties,
although
further
research
is
needed
address
toxicity
concerns.
Pollen
jelly
demonstrate
broad-spectrum
activity,
which
relevant
animal
health.
Existing
pre-clinical
clinical
support
these
hive
products.
products
represent
vast
largely
untapped
natural
resource
combating
resistance
developing
sustainable
therapies,
field
medicine.
However,
challenges
remain
due
inherent
variability
composition
lack
standardized
protocols
preparation
application.
Further
essential
fully
elucidate
optimize
formulations
enhanced
efficacy,
establish
safe
effective
use.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(2), P. 349 - 349
Published: Feb. 17, 2025
Background
and
Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
clinical
pathological
syndrome
characterized
by
steatosis
fat
accumulation
in
parenchymal
cells
patients
without
history
of
excessive
alcohol
drinking.
Currently,
there
no
definitive
treatment
for
MASLD,
its
prevalence
increases
with
age
obesity,
after
menopause.
Among
the
ways
to
treat
it,
we
can
mention
regular
sports
exercises
use
natural
supplements.
Therefore,
aim
this
research
investigate
compare
effects
aerobic-resistance
training
royal
jelly
supplementation
on
changes
paraoxonase
1,
oxidized
LDL,
function,
lipid
profile
postmenopausal
women
Dysfunction-Associated
Steatotic
Liver
Disease.
Materials
Methods:
This
semi-experimental
study
involved
23
Disease
an
average
weight
(71.34
±
11.63
kg),
(48.54
3.88
years),
body
mass
index
(27.63
4.20
kg/m2).
They
were
randomly
divided
into
two
groups:
exercise
+
supplement
(n
=
12)
placebo
11).
Both
groups
performed
eight-station
resistance
(8-12
repetitions
2-4
sets)
8
weeks,
three
sessions
per
week
(for
35-40
min,
from
10-15
RPE),
then,
min
active
rest,
they
aerobic
intensity
40-85%
target
heart
rate,
two-minute
intervals
45
s
rest.
Royal
(500
mg
days,
before
each
session)
was
consumed.
Blood
sampling
done
48
h
last
session.
Statistical
analysis
using
variance
test
repeated
measures
(two
×
stages
pre-test-post-test)
SPSS
software
(Version
26)
significance
level
p
<
0.05.
Results:
The
results
statistical
show
that
eight
weeks
PON1,
oxLDL,
profiles
(HDL,
TC,
TG),
enzymes
(ALT,
AST)
non-alcoholic
fatty
showed
significant
difference
(p
0.05).
increase
PON1
0.008)
HDL
0.005)
group
compared
group.
But
decreases
oxLDL
0.031),
TC
0.045),
TG
0.013),
LDL
0.027),
ALT
0.015)
AST
0.009)
observed
(<0.05).
However,
0.015),
Conclusions:
Based
results,
it
be
concluded
addition
probably
efficient
recommended
strategy
minimize
harmful
affecting
activity
enzymes,
oxidation,
profile.
Although
alone
also
yielded
favorable
according
findings
research,
said
exercise,
combined
supplements,
may
have
more
positive
reducing
complications
improving
function.
order
obtain
accurate
scientific
evidence,
necessary
doses
timing
future
studies.
Trials,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Feb. 26, 2025
In
the
field
of
global
health,
meeting
energy
requirements
athletes
has
surfaced
as
an
essential
concern.
This
study
seeks
to
evaluate
effectiveness
royal
jelly
(RJ)
in
improving
exercise
performance
endurance-trained
men.
this
randomized,
crossover,
double-blind,
placebo-controlled
study,
we
will
enroll
18
male
endurance
athletes.
Participants
be
randomly
assigned
one
two
conditions:
intervention
condition,
which
receive
500
mg
capsules
taken
orally
twice
daily
for
2
weeks,
or
control
a
placebo
consisting
starch
same
duration.
The
utilize
×
crossover
design
with
2-week
washout
period
between
treatments.
To
aerobic
performance,
determine
each
participant's
maximal
speed
(MAS),
followed
by
test
conducted
at
80%
MAS
measure
time
exhaustion.
Blood
samples
(5
cc)
collected
from
all
participants
before
and
after
treadmill
tests
analyze
mRNA
expressions
Nrf2
PGC-1α,
well
oxidative
stress
parameters.
Additionally,
participants'
dietary
intake
assessed
using
3-day
food
records,
their
blood
pressure
monitored
exercise,
immediately
after,
half
hour
post-exercise.
trial
aims
RJ
nutraceutical
agent
enhancing
athletic
performance.
We
anticipate
that
results
provide
new
insights
into
clinical
molecular
benefits
RJ.
these
findings
offer
valuable
data
guide
execution
future
research
involving
was
registered
Iranian
Registry
Clinical
Trials
(registration
No.
IRCT20231209060310N1,
date:
December
21,
2023).
International journal of Nutrition Pharmacology Neurological Diseases,
Journal Year:
2025,
Volume and Issue:
15(1), P. 35 - 42
Published: Jan. 1, 2025
Objective:
To
perform
a
scientometric
mapping
analysis
of
the
published
literature
on
royal
jelly
(RJ)
supplementation,
oxidative
stress
(OS),
and
inflammatory
mediators.
Materials
Methods:
A
comprehensive
search
Scopus
was
performed
using
targeted
strategy
July
13,
2024.
All
manuscripts
from
January
2019
to
2024
that
addressed
RJ
supplementation
OS
or
mediators
were
selected.
Data
extracted
selected
analyzed
various
metrics
in
SciVal
R
studio
version
4.3.2.
Results:
Antioxidants
foods
had
highest
academic
output,
with
three
articles
each
citation
count
184
71,
respectively.
also
showed
high
CiteScore
10.6
2023.
Biomedicine
pharmacotherapy
remarkably
11.9
two
articles.
Despite
having
only
articles,
Journal
Asia-Pacific
Entomology
an
impressive
73.
Cyrus
Jalili
Kermanshah
University
Medical
Sciences
Iran
output
six
publications.
Amira
Mohammed
Ali
Alexandria
Egypt
number
views
per
publication,
37.3.
Conclusion:
The
most
productive
authors
institutions
identified,
Egypt.
Lotka’s
law
confirmed,
contributed
single
article.
In
addition,
extensive
international
collaboration
observed,
underscoring
importance
global
this
area
research.