Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1296 - 1296
Published: Dec. 23, 2024
Background/Objectives:
Military
aviators
can
be
exposed
to
extreme
physiological
stressors,
including
decompression
stress,
G-forces,
as
well
intermittent
hypoxia
and/or
hyperoxia,
which
may
contribute
neurobiological
dysfunction/damage.
This
study
aimed
investigate
the
levels
of
neurological
biomarkers
in
military
assess
potential
risk
long-term
brain
injury
and
neurodegeneration.
Methods:
cross-sectional
involved
48
Canadian
Armed
Forces
(CAF)
non-aviator
CAF
controls.
Plasma
samples
were
analyzed
for
glial
activation
(GFAP),
axonal
damage
(NF-L,
pNF-H),
oxidative
stress
(PRDX-6),
neurodegeneration
(T-tau),
along
with
S100b,
NSE,
UCHL-1.
The
biomarker
concentrations
quantified
using
multiplexed
immunoassays.
Results:
exhibited
significantly
elevated
GFAP,
NF-L,
PRDX-6,
T-tau
compared
controls
(p
<
0.001),
indicating
increased
activation,
injury,
stress.
Trends
toward
higher
UCHL-1
observed
but
not
statistically
significant.
suggest
cumulative
damage,
raising
concerns
about
impairments.
Conclusions:
are
at
early
These
findings
emphasize
importance
proactive
monitoring
further
research
understand
impacts
high-altitude
flight
on
health
develop
strategies
mitigating
cognitive
decline
neurodegenerative
risks
this
population.
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: March 17, 2025
Postmortem
studies
have
shown
the
presence
of
subpial
inflammation
with
tertiary
lymphoid
organs
(TLO)
in
meninges
patients
progressive
multiple
sclerosis,
playing
an
important
role
pathophysiology
disease.
The
chemokine
(C-X-C
motif)
ligand
13
(CXCL13)
induces
formation
these
organs,
thus
promoting
activity
progression
to
disability
sclerosis
has
been
reduced,
thanks
effect
disease
modifying
therapy.
However,
despite
advances
treatment
immunomodulatory
agents,
we
still
lack
specific
laboratory
biomarkers
that
could
indicate
state
disease,
either
at
time
diagnosis
or
when
escalation
therapy
seems
be
mandatory.
In
MRI
not
demonstrated
TLO
CNS,
so
far.
determination
CXCL13
index
(ICXCL
13),
clinical
specimens,
become
a
reliable
biomarker
for
verification
and
TLO,
contributing
improving
outcome,
high
efficacy
therapy,
setting.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 26, 2024
Malignant
tumors
of
the
hematologic
system
have
a
high
degree
malignancy
and
mortality
rates.
Chimeric
antigen
receptor
T
cell
(CAR-T)
therapy
has
become
an
important
option
for
patients
with
relapsed/refractory
tumors,
showing
astonishing
therapeutic
effects
thus,
it
brought
new
hope
to
treatment
malignant
system.
Despite
significant
CAR-T,
its
toxic
reactions,
such
as
Cytokine
Release
Syndrome
(CRS)
Immune
Effector
Cell-Associated
Neurotoxicity
(ICANS),
cannot
be
ignored
since
they
can
cause
damage
multiple
systems,
including
cardiovascular
We
summarize
biomarkers
related
prediction,
diagnosis,
efficacy,
prognosis,
further
exploring
potential
monitoring
indicators
toxicity
prevention.
This
review
aims
CAR-T
on
cardiovascular,
hematologic,
nervous
well
biomarkers,
explore
preventing
toxicity,
thereby
providing
references
clinical
regulation
assessment
effects.
