Journal of Medicine and Life,
Journal Year:
2024,
Volume and Issue:
17(10), P. 948 - 952
Published: Oct. 1, 2024
The
connection
between
the
immune
response
and
composition
of
gut
microbiota
has
been
associated
with
an
increased
prevalence
atopic
dermatitis
in
first
year
life.
study
aimed
to
investigate
characteristics
infants
compared
healthy
better
understand
link
early-life
development
dermatitis.
analyzed
intestinal
121
clinical
signs
dermatitis,
divided
into
Group
I
(infants
dermatitis)
II
(healthy
controls).
showed
that
presented
values
proteolytic
bacteria
mainly
represented
by
Enterobacter
species
(P
=
0.041),
Klebsiella
0.038),
Escherichia
coli
0.013),
significantly
decreased
levels
acidifying
Enterococcus
species,
Lactobacillus
Bifidobacterium
<
0.05)
normal
Clostridium
Candida
albicans,
Mould
fungi
Geotrichum
species.
This
highlights
distinct
differences
providing
insights
dynamic
ecosystem
during
early
life
for
future
personalized
therapeutic
strategies.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 14, 2025
Atopic
dermatitis
(AD)
is
a
chronic
and
inflammatory
skin
disorder
characterized
by
impaired
barrier
function
imbalanced
immunity.
Recent
advances
have
revealed
that
dysbiosis
of
microbiota
plays
important
roles
in
the
pathogenesis
development
AD.
Meanwhile,
endogenous
external
factors
contribute
to
Additionally,
various
treatments,
including
topical
phototherapy,
systemic
biologics,
demonstrated
positive
impacts
on
clinical
outcomes,
alongside
with
modulations
cutaneous
AD
patients.
Importantly,
therapeutics
or
products
regulating
homeostasis
potential
for
treatment
early
studies.
In
this
review,
we
underline
changes
correlated
provide
an
overview
regarding
its
Finally,
summarize
therapeutic
strategies
restoring
microbial
management.
Exploration of Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
The
gut
microbiota,
a
complex
ecosystem
of
microorganisms,
plays
an
essential
role
in
maintaining
immune
and
metabolic
homeostasis.
Disruption
this
microbial
balance,
known
as
dysbiosis,
has
been
increasingly
implicated
the
pathogenesis
chronic
inflammatory
conditions,
including
cardiovascular,
gastrointestinal,
autoimmune
diseases,
well
disorders
such
diabetes
obesity.
A
crucial
mechanism
through
which
microbiota
exerts
its
effects
on
host
physiology
is
via
production
bioactive
metabolites.
These
metabolites,
short-chain
fatty
acids,
bile
tryptophan
derivatives,
are
key
modulating
responses
regulating
functions.
Dysbiosis
disrupts
function
these
thereby
contributing
to
dysregulation,
inflammation,
disease
progression.
This
review
examines
microbiota-derived
metabolites
with
focus
their
immunomodulatory
effects.
deeper
understanding
mechanisms
may
open
way
for
novel
therapeutic
strategies
aimed
at
restoring
homeostasis
mitigating
global
burden
diseases.
Cosmetics,
Journal Year:
2025,
Volume and Issue:
12(1), P. 24 - 24
Published: Feb. 3, 2025
The
inherent
acidic
nature
of
the
stratum
corneum
(SC),
so-called
“acid
mantle”,
has
a
multitude
effects
on
skin
barrier
integrity
owing
to
its
(patho)physiological
role
in
homeostasis,
antimicrobial
defense,
and
inflammation.
Several
salient
SC
acidifying
mechanisms,
including
breakdown
FLG
(filaggrin)
protein,
lipid
processing,
activity
sodium
proton
pump
SLC9A1/NHE1,
are
indispensable
for
structural
functional
cohesion
as
they
contribute
immensely
origin,
generation,
maintenance,
overall
acidification
surface
pH
(pHss).
As
many
endogenous
exogenous
factors
can
affect
pHss,
pHss
inevitably
deviate
from
optimum.
elevation
is
often
accompanied
by
abnormalities
metabolism
organization,
cohesion,
commonly
observed
eczema,
which
associated
with
symptoms
dry
skin,
inflammation,
pruritus,
infection.
In
psoriasis,
it
seems
that
altered
well;
however,
this
case,
likely
be
lower
than
physiological
pHss.
Due
negative
an
both
eczema
been
suggested
maintain
at
levels
utilizing
pH-balanced
topical
cleansers
moisturizers
improve
skin’s
benefiting
moisturization
regeneration
organization
barrier.
principal
aim
review
gather
understanding
existing
research
stimulate
critical
thinking
inspire
innovative
ideas
about
‘known
unknowns’,
considering
intricate
nature,
prime
human
health,
well
pathogenesis
psoriasis.
Veterinary Sciences,
Journal Year:
2025,
Volume and Issue:
12(3), P. 226 - 226
Published: March 2, 2025
Canine
atopic
dermatitis
(AD)
is
a
T-cell-driven
inflammatory
skin
disease,
characterized
by
an
imbalance
between
the
Th1
and
Th2
immune
responses.
Probiotics
(live
bacteria)
postbiotics
(inactivated,
killed
have
garnered
attention
for
management
of
AD
in
humans
dogs.
Both
probiotics
possess
immunomodulating
properties
that
could
be
beneficial
allergic
patients.
This
study
aims
to
evaluate
effects
Tyndallized
(heat-killed)
Lactobacillus
rhamnosus
reuteri,
which
are
active
components
Linkskin
products
(Nextmune,
Palazzo
Pignano,
Cremona,
Italy).
Peripheral
blood
mononuclear
cells
(PBMCs)
were
isolated
from
healthy
dogs
incubated
separately
with
each
postbiotic.
The
cytokine
levels
supernatants
measured
before
after
12,
24,
48,
72
h
incubation.
lactobacilli
significantly
increased
IL-12
IFN-γ
(Th1
cytokines)
IL-10
(associated
T
regulatory
cells),
while
IL-4
remained
stable.
Overall,
these
two
stimulated
canine
PBMCs
produce
profile
typically
associated
anti-allergic
response.
Further
studies
needed
benefit
as
adjuvant
reactive
treatment
or
prevention
relapses
flares
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1082 - 1082
Published: May 7, 2025
Recent
studies
have
emphasized
the
impact
of
gut
microbiota
on
skin
health,
but
reverse,
how
diseases
affect
homeostasis,
has
received
less
attention.
Allergic
contact
dermatitis
(ACD),
a
common
disorder
affecting
one
in
four
people
worldwide,
can
be
accompanied
by
intestinal
disturbances.
To
explore
this,
we
used
an
experimental
model
ACD
to
investigate
changes
induced
disease.
Parameters
assessed
included
microbiota,
short-chain
fatty
acids
(SCFAs),
gene
expression
related
permeability,
inflammatory
cytokines,
and
mucus
production.
evaluate
potential
therapeutic
interventions,
probiotic
Bifidobacterium
longum
strain
BB536
was
administered
via
gavage,
starting
10
days
before
induction
continuing
until
last
day
disease
induction.
caused
alterations
composition
compared
naïve
mice
did
not
SCFA
The
altered
increased
acetate
production
dermatitis-induced
mice.
decreased
TjP1,
ATHO1,
MUC2,
while
treatment
restored
TjP1
ATHO1
normal
levels.
cytokine
IL-6
group
mice,
whereas
IL-10
decreased;
also
these
Intestinal
production,
affected
ACD,
partially
treatment.
findings
suggest
that
probiotics
could
strategy
prevent
issues
diseases.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2351 - 2351
Published: Oct. 15, 2024
Background.
Currently,
it
is
known
that
the
gut
microbiota
plays
an
important
role
in
functioning
of
immune
system,
and
a
rebalancing
bacterial
community
can
arouse
complex
reactions
lead
to
immune-mediated
responses
organism,
particular,
development
atopic
dermatitis
(AD).
Cytokines
chemokines
are
regulators
innate
adaptive
response
represent
most
biomarkers
system.
It
changes
cytokine
profiles
hallmark
many
diseases,
including
atopy.
However,
remains
unclear
how
imbalance
disrupts
function
AD.
Objectives.
We
attempted
determine
bacteria
modulating
pathways
their
inflammation.
Methods.
sequenced
16S
rRNA
gene
from
50
stool
samples
children
aged
3–12
years
who
had
confirmed
dermatitis,
healthy
serve
as
control
group.
To
evaluate
status,
we
conducted
multiplex
immunofluorescence
assay
measured
levels
41
cytokines
serum
all
participants.
Results.
find
out
whether
composition
were
significantly
associated
with
level
inflammatory
cytokines,
correlation
was
calculated
between
each
pair
family
cytokine.
In
AD
group,
191
correlations
significant
(Spearman’s
coefficient,
p
≤
0.05),
85
which
positive
106
negative.
Conclusions.
has
been
demonstrated
intestinal
dysbiosis
alterations
profiles,
specifically
increase
proinflammatory
concentrations.
This
may
indicate
systemic
impact
these
conditions,
leading
system’s
Th2
type.
As
result,
conditions
develop.
Additionally,
(IL-5,
IL-8,
IL-13,
CCL22,
IFN-γ,
TNF-α)
abundance
families
(Pasteurellaceae,
Barnesiellaceae,
Eubacteriaceae)
observed.
Cells,
Journal Year:
2024,
Volume and Issue:
13(22), P. 1899 - 1899
Published: Nov. 18, 2024
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disease
with
multifactorial
and
unclear
pathogenesis.
Its
development
characterized
by
two
key
elements:
epigenetic
dysregulation
of
molecular
pathways
involved
in
AD
pathogenesis
disrupted
gut
microbiota
(dysbiosis)
that
jointly
trigger
maintain
inflammation,
core
characteristic.
Current
data
suggest
failed
inflammation
resolution
the
main
pathogenic
mechanism
underlying
development.
Inflammation
provided
specialized
pro-resolving
mediators
(SPMs)
derived
from
dietary
polyunsaturated
fatty
acids
acting
through
cognate
receptors.
SPM
levels
are
reduced
patients.
Administration
SPMs
or
their
stable,
small-molecule
mimetics
receptor
agonists,
as
well
supplementation
probiotics/prebiotics,
demonstrate
beneficial
effects
animal
models.
Epidrugs,
compounds
capable
restoring
mechanisms
associated
disease,
improve
impaired
barrier
function
Based
on
these
findings,
we
propose
novel,
multilevel
treatment
strategy
aimed
at
resolving
application
epi-drugs.
This
approach
can
be
used
conjunction
current
therapy,
resulting
alleviation.
