LincRNA-EPS Promotes Proliferation of Aged Dermal Fibroblast by Inducing CCND1 DOI Open Access
Liping Zhang,

Iris C. Wang,

Songmei Meng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7677 - 7677

Published: July 12, 2024

The aging process is linked to numerous cellular changes, among which are modifications in the functionality of dermal fibroblasts. These fibroblasts play a crucial role sustaining healing skin wounds. Reduced cell proliferation hallmark feature aged Long intergenic non-coding RNA (lincRNAs), such as LincRNA-EPS (Erythroid ProSurvival), has been implicated various processes. However, its and impact on cycle regulator, Cyclin D1 (CCND1), remains unclear. Primary were isolated from 17-week-old (young) 88-week-old (aged) mice. Overexpression was achieved through plasmid transfection. Cell detected using MTT assay. Real-time PCR used quantify relative gene expressions. Our findings indicate noteworthy decline expression fibroblasts, accompanied by reduced levels CCND1 diminished these cells. Significantly, overexpression resulted an upregulation substantial increase proliferation. Mechanistically, induces sequestering miR-34a, dysregulated directly targeting CCND1. outcomes underscore regulating promoting study provides novel insights into molecular mechanisms underlying age-related changes their implications for wound healing. significant reduction ability induce enhance highlight potential therapeutic target addressing

Language: Английский

miRNAs and their multifaceted role in cutaneous wound healing DOI
Reda Mansour,

Sherif S. Abdel Mageed,

Farah A. Awad

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 4, 2025

Language: Английский

Citations

1
Ultraviolet Light Causes Skin Cell Senescence: From Mechanism to Prevention Principle DOI

Shujia Song,

Fuxing Li, Bing-Xiang Zhao

et al.

Advanced Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract The skin is an effective protective barrier that significantly protects the body from damage caused by external environmental factors. Furthermore, condition affects beauty. In today's era, which of material and spiritual prosperity, there growing attention on skincare wellness. Ultraviolet radiation one most common factors lead to conditions like sunburn, cancer, aging. this review, several mechanisms UV‐induced cell senescence are discussed, including DNA damage, oxidative stress, inflammatory response, mitochondrial dysfunction, have their own characteristics mutual effects. As illustration, dysfunction triggers electron evasion generation more reactive oxygen species, leading stress activation NLRP3 inflammasome, in turn causes (mt DNA) damage. Based current mechanism, suitable prevention treatment strategies proposed sunscreen, dietary, experimental medications respectively, aimed at slowing down aging providing protection ultraviolet radiation. effects rays summarized, offering insights directions for future studies mechanism senescence, with anticipation discovering cure methods.

Language: Английский

Citations

4
MicroRNAs in the Mitochondria–Telomere Axis: Novel Insights into Cancer Development and Potential Therapeutic Targets DOI Open Access
José Alfonso Cruz-Ramos,

Emmanuel De La Mora-Jiménez,

Beatriz Alejandra Llanes-Cervantes

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 268 - 268

Published: Feb. 25, 2025

The mitochondria–telomere axis is recognized as an important factor in the processes of metabolism, aging and oncogenesis. MicroRNAs (miRNAs) play essential function this complex interaction, having impact on aspects such cellular homeostasis, oxidative responses apoptosis. In recent years, miRNAs have been found to be crucial for telomeric stability, well mitochondrial behavior, factors that influence cell proliferation viability. Furthermore, (mitomiRs) are associated with gene expression activity cGAS/STING pathway activity, linking DNA recognition immune system responses. Hence, maintain a link biogenesis, metabolic changes cancer organelles. This review focuses roles variety progression their potential application biomarkers or therapeutic agents.

Language: Английский

Citations

0
Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis DOI Open Access

Răzvan-Ionuț Zimbru,

Elena-Larisa Zimbru,

Florina Bojin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3570 - 3570

Published: April 10, 2025

Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines how miRNAs contribute to the complex interplay between asthma atherosclerosis, focusing on involved pathways, immune cell regulation vascular remodeling. We discuss specific miRNAs, such as miR-155, miR-21 miR-146a, which have been shown cytokine production T differentiation, impacting respiratory cardiovascular health. The found both emphasize their role biomarkers, also therapeutic targets. Understanding molecular connections may unlock novel approaches for innovative, integrated treatment strategies address significantly improve patient outcomes. Further research is needed explore mechanistic pathways validate translational of miRNA-based interventions preclinical clinical settings.

Language: Английский

Citations

0
LincRNA-EPS Promotes Proliferation of Aged Dermal Fibroblast by Inducing CCND1 DOI Open Access
Liping Zhang,

Iris C. Wang,

Songmei Meng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7677 - 7677

Published: July 12, 2024

The aging process is linked to numerous cellular changes, among which are modifications in the functionality of dermal fibroblasts. These fibroblasts play a crucial role sustaining healing skin wounds. Reduced cell proliferation hallmark feature aged Long intergenic non-coding RNA (lincRNAs), such as LincRNA-EPS (Erythroid ProSurvival), has been implicated various processes. However, its and impact on cycle regulator, Cyclin D1 (CCND1), remains unclear. Primary were isolated from 17-week-old (young) 88-week-old (aged) mice. Overexpression was achieved through plasmid transfection. Cell detected using MTT assay. Real-time PCR used quantify relative gene expressions. Our findings indicate noteworthy decline expression fibroblasts, accompanied by reduced levels CCND1 diminished these cells. Significantly, overexpression resulted an upregulation substantial increase proliferation. Mechanistically, induces sequestering miR-34a, dysregulated directly targeting CCND1. outcomes underscore regulating promoting study provides novel insights into molecular mechanisms underlying age-related changes their implications for wound healing. significant reduction ability induce enhance highlight potential therapeutic target addressing

Language: Английский

Citations

1